AN organic thiophosphate compound, WR-2721 (S-2-(3-aminopropylaminoethyl)phosphorothioic acid), protects normal but not malignant animal tissues against the toxicity of ionizing radiation and chemotherapy with alkylating agents.^{1 2 3} WR-2721 is ...

CHILDREN with craniopharyngioma frequently have delayed growth and short stature secondary to impaired hypothalamo-pituitary function. After removal of the tumor, the growth rate remains low in most patients.¹ In some children, however, the postoperative ...

A RELATION between sleep behavior (i.e., time taken to fall asleep and frequency of night waking) and serotonergic neurotransmission has been indicated by previous studies in human adults and in nonhuman species.^{1 2 3} The synthesis and release of ...

SPHENOID sinus infection is frequently misdiagnosed on initial evaluation.¹ Situated deep in the apex of the nasal cavity, the sphenoid sinus is not accessible to direct clinical examination and is often not seen clearly on routine radiologic examination. ...

FROM 1960 to 1980, American health-care expenditures rose an average of 11.7 per cent per year, more rapidly than any other sector of the economy. As a result, the percentage of the gross national product spent on medical care rose from 5.2 per cent in ...

COMPUTED tomography (CT) of the body (excluding the head and neck) has become a well-established, important, and sometimes crucial noninvasive imaging examination. Once regarded as a paradigm of high-cost technology of unproved value,¹ CT has evolved as a ...

EXTERNAL cardiac pacing for asystole was introduced in 1952.¹ Before then there was no effective method of restoring the heartbeat during complete heart block, and the annual mortality after a Stokes-Adams attack was 50 per cent. Although external cardiac ...

WE describe a patient with severe hypoxic brain damage after near drowning, whose auditory brain-stem responses disappeared but subsequently reappeared. This case suggests that the loss of auditory brain-stem responses may be reversible and cannot be used ...

Presentation of Case

A 31-year-old man was admitted to the hospital because of chest pain and a mass in the anterior thoracic wall.

He was well until 3 1/2 months earlier, when he experienced left anterior chest pain. He was seen at another hospital, ...

More than 30 years ago, Zoll¹ demonstrated the life-saving application of external electrical stimulation of the arrested heart. Now he and his colleagues² have improved on that technique. In this issue of the Journal, they show that even in this ...

IN 1977 the Journal published the results of the Veterans Administration randomized trial of coronary-artery bypass grafting (CABG).¹ In an accompanying editorial² I stated: "This report confirms the widely held impression that CABG reduces the incidence ...

Pressure from the federal government and industry to improve the efficiency of medical-care delivery will continue to increase. There is considerable evidence that various kinds of overuse are common, but traditional medical education, conflicting ...

To the Editor: The acquired immunodeficiency syndrome (AIDS), the cause of which remains unknown, has been described in homosexual men and parenteral drug abusers in the United States.¹ Hemophiliacs and sexual partners of patients with AIDS also seem to ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

To the Editor: Hirsch et al. report the results of a randomized controlled trial of the effects of interferon on cytomegalovirus reactivation syndromes in recipients of renal transplants (June 23 issue).¹ A total of 48 patients were randomly assigned to ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

This is a balanced, compassionate, and psychologically sophisticated portrait of Barbara McClintock, born in 1902, one of the few women of her generation to become a research scientist, and this year's Nobel laureate in medicine and physiology. McClintock ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

This book is a testimonial to the fact that the field of psychoeducational assessment has come of age. Before the 1960s there existed few reliable and valid instruments for the assessment of the young child. We now have many. This book contains 20 ...

Adolescent medicine has come of age. Now over 30 years old, it is a field that is entering its prime. We seem to be entering a new age for pediatrics, in which all pediatricians should be competent to treat teenagers until they go off to work or to ...

No extract is available for articles shorter than 400 words.

This book, consisting of approximately 1000 pages, falls somewhere in size between a manual and a standard textbook. It contains 34 chapters devoted to disorders of body systems in infants and children, but with the addition of several general topics.

The ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

REDUCING RISKS OF LABORATORY INFECTIONS

The 1983 National Institutes of Health Research Safety Symposium will be held at the Twin Bridges Marriott Hotel in Arlington, Va., on December 1 and 2. The topic will be "Reducing the Risk of Infection in ...

Immunotherapputic interventions are now being used in the treatment of a number of diseases thought to be of immune origin or to have a major component involving the immune system. These diseases include various vasculitides, rheumatoid arthritis, ...