EVIDENCE that the glomerular capillaries act as both a size and a charge barrier in the formation of the plasma ultrafiltrate¹ has accumulated during the past 10 years. Histochemical observations of kidneys from rats with proteinuria induced by the ...

ESSENTIAL hypertension has a high prevalence among blacks,¹ appears to have a genetic basis,² and by definition, has no known cause. However, both Guyton³ and Bianchi et al.⁴ have suggested that the kidney is primarily at fault in essential hypertension. ...

THE availability of a biologically active human growth hormone produced by recombinant-DNA technology¹ has dramatically changed the therapeutic prospects for children with short stature. Since Raben's original report that human growth hormone promoted ...

ALTHOUGH there is little doubt that current methods of treatment improve the signs and symptoms of rheumatoid arthritis in most patients,^{1 2 3} it is uncertain whether currently available therapy can prevent or retard joint damage, particularly as ...

ALTHOUGH the presence of a goiter in a patient with autoimmune thyroid disease is often the first indication of thyroid dysfunction, the mechanism of goiter formation is not well understood. Recently, Doniach et al.¹ have suggested that goiter may be ...

Cytomegalovirus

Cytomegalovirus is a major cause of congenital malformations and an important opportunistic pathogen in immunocompromised hosts.¹¹² In transplant recipients, it may cause interstitial pneumonitis, fever–leukopenia syndromes, hepatitis, ...

THE neutropenias of childhood are a group of disorders sharing the common features of neutropenia and increased frequency of bacterial infections.¹ Several mechanisms underlie these diseases, including a deficiency of stem-cell development, failure of ...

Presentation of Case

A 76-year-old man was admitted to the hospital because of pain and swelling in the left knee.

There was a 35-year history of pain in the left knee after an athletic injury. Twelve years before admission the pain worsened; indomethacin ...

Proteinuria is the hallmark of glomerular injury, and the study of its mechanisms remains a subject of considerable interest. In recent years, physiologic, ultrastructural, immunochemical, and biochemical techniques have established the importance to ...

IN this issue the report by Curtis et al.¹ on the remission of essential hypertension in six patients after renal transplantation provides additional support for the view that renal dysfunction is a primary cause of the disease. Their six patients, all ...

Twelve years ago I presented a presidential address entitled "In Defense of the Establishment" to the Western Society for Clinical Research.¹ It was a time when medical schools were being blamed for almost all the ills that were plaguing American medicine,...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

To the Editor: The dementia of Alzheimer's disease incapacitates many elderly people in the United States. The diagnosis can usually be verified on autopsy by characteristic neuropathologic changes. However, this and other conditions with similar ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

To the Editor: In their paper in the June 30 issue Prochownik et al. demonstrated genetic molecular heterogeneity of inherited anti-thrombin III deficiency, using recombinant-DNA techniques.¹ The same authors had previously shown that normal subjects had ...

To the Editor: Investigators have suggested that the acquired immunodeficiency syndrome (AIDS) results from a transmissible infectious agent, probably a virus.¹ We propose a nonviral infectious agent as either a possible primary causative agent of AIDS ...

I recently undertook a study of advertisements for weight-loss schemes and the multitude of nostrums, pills, devices, diets, techniques, and tonics offered through the mails that promise to metamorphose the buyer magically into a slimmer, sexier, ...

During the period 1980–1983 we have favored two new policies to assist our readers in the evaluation of books. The first has been the frequent use of double or triple reviews (a sort of microgrouping), and the second, a weekly macrogrouping or clustering ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

This book offers a timely reconsideration of the role of inhaled steroids in the treatment of asthma by a group of enthusiasts from the United Kingdom. The authors discuss their extensive personal experiences in the management of asthma with inhaled ...

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PATHOLOGY

The ninth annual "Review and Recent Practical Advances in Pathology" will be held in Miami Beach, Fla., January 23–27.

Contact the Department of Pathology D-33, University of Miami School of Medicine, P.O. Box 016960, Miami, FL 33101; or call (...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.