WILSON'S disease may have a myriad of clinical manifestations. The classic findings are hepatic, neurologic, and renal disease. Large amounts of copper are deposited in the liver, brain, and other tissues.¹ Other common manifestations include hemolytic ...

EXPOSURE to high concentrations of oxygen for prolonged periods causes a form of acute lung injury termed "oxygen toxicity."^{1 2 3 4} Although the upper airways are mildly affected,^{5 , 6} the most serious damage is to the lower respiratory tract, ...

EPITHELIAL ovarian carcinomas are among the malignant diseases that respond to treatment with cytoreductive surgery, radiotherapy, and cytotoxic chemotherapy.¹ Monitoring the response to treatment has been difficult, however, because these tumors often ...

THE possible role of divalent cations in the pathogenesis of essential hypertension has recently received increasing attention.^{1 , 2} Certain studies have suggested a positive correlation of serum total calcium levels with the height of the blood pressure.^...

AMERICANS make over half a billion office visits per year to private physicians in the United States — an average of 2.7 visits per person.¹ These patients are seen by over 250,000 physicians in 28 recognized clinical specialties and account for more than ...

NORMALLY, the bulk of total serum thyroxine (T₄), approximately 80 per cent, is bound to T₄-binding globulin, a glycoprotein synthesized in the liver. An elevation in the serum concentration of this protein that is genetic in origin and unrelated to ...

A DEFICIENCY in the enzyme hypoxanthineguanine phosphoribosyltransferase (HPRT) is associated with two clinical syndromes. Enzyme activity is virtually absent in the Lesch-Nyhan syndrome.¹ This disease is characterized by overproduction of uric acid and a ...

Presentation of Case

A 39-year-old man was admitted to the hospital because of a gastric mass.

There was a history of polyarthritis, which began at the age of 19 years and was accompanied by occasional episodes of crampy lower abdominal pain that was ...

I love the doctors — they are dears; But must they spend such years and years Investigating such a lot Of illnesses which no one's got, When everybody, young and old, Is frantic with the common cold? And I will eat my only hat If they know anything of ...

AS many women die from ovarian cancer in the United States each year as from all other cancers of the genital tract combined. ¹ If for no other reason, any development that raises the hope of improving our ability to diagnose or treat this cancer deserves ...

Studies of clinical problem solving show that physicians form diagnostic hypotheses on the basis of minimal clinical findings and that these hypotheses create a context within which to gather additional relevant data.^{1 , 2} By an iterative process, ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

To the Editor: Dr. Kirshner describes a patient in whom toxicity developed when she switched her daily 450-mg dose of phenytoin from four 100-mg capsules and one 50-mg chewable tablet to nine 50-mg chewable tablets (May 5 issue).¹ Kirshner states that ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

How will the changes that batter the American medical system affect its academic medical centers? Is there a reasonable and organized way for the centers to adjust to these changes? The Sick Citadel provides a carefully reasoned analysis with which to ...

Reform designed to foster more price competition in the nation's health-care marketplace continues to receive attention in Congress. The legislative focus is on controlling expense by restructuring the marketplace to make its providers, consumers, and ...

Much of the immense literature in bioethics is highly specialized, though there have been a number of attempts to provide a general overview. Among these one finds several collections and textbooks that one might consider introductory for a course in ...

The papers collected in Ethics and Animals are from a conference entitled "The Moral Foundations of Public Policy: Ethics and Animals." The book's title suggests that the views expressed are balanced, but this is not the case. Of the 25 papers included, ...

SEMINARS IN MEDICINE OF THE BETH ISRAEL HOSPITAL, BOSTON

The Hospital will present two seminars in October in Grossman Conference Center of Kirstein Hall at 4:30 p.m.: "Pseudohypoparathyroidism: Hormone Resistance Caused by Defects in the Receptor-...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

Cost containment in the health-care sector has increasingly been seen as a predominant public-policy goal.¹ Because Medicare and Medicaid pay for some 27 per cent of all health care in the nation,² they have the potential for exerting a considerable ...