THE immunosuppressive properties of cyclosporine (previously called cyclosporin A) were described by Borel in 1976,¹ and its ability to prolong graft survival without bone-marrow suppression was initially demonstrated by Calne et al.² Further clinical ...

VON Willebrand's disease is an inherited disorder of hemostasis due to quantitative or qualitative abnormalities of factor VIII/von Willebrand factor, a protein present in plasma and platelets in the form of multimers.^{1 2 3} Various subtypes of the disease ...

CYSTIC hygromas are congenital malformations of the lymphatic system appearing as single or multiloculated fluid-filled cavities, most often about the neck.^{1 , 2} Previous clinical studies have focused on localized cystic hygromas in otherwise normal ...

CYTOGENETIC and isoenzyme studies have established that chronic myelogenous leukemia is a clonal proliferative disorder arising from a progenitor cell with a rather pluripotential capacity.^{1 2 3 4 5 6} Studies of glucose-6-phosphate dehydrogenase ...

SINCE restriction-enzyme techniques for prenatal diagnosis of sickle-cell anemia by amniocentesis at about 17 weeks of gestation were developed by Chang and Kan¹ and by Orkin et al.,² emphasis has focused on techniques to permit diagnosis earlier in ...

Gynecologic Radiation Oncology

Cancer of the Uterine Cervix

Treatment results for invasive carcinoma of the cervix have been good in the past, with an overall disease-free five-year survival rate of 65 per cent.³ There has not been much improvement in the ...

THE most common symptomatic arteriosclerotic lesion of the peripheral arteries is occlusion of the superficial femoral artery. Occlusive disease of the abdominal aorta and iliac arteries is encountered less frequently but is nevertheless a common cause of ...

Presentation of Case

A 40-year-old woman was admitted to the hospital because of fever and a right preauricular mass.

She was well until six years earlier, when pain developed in the left ear. Several months later headaches appeared, and she noticed ...

Chronic myelocytic leukemia is a disease in which biomedical research efforts have paid substantial dividends in recent years. Both laboratory and clinical investigators have found that this disease, first described as "splenic leukemia" over 100 years ...

In 1977 Foti et al.¹ described a new radioimmunoassay for prostatic acid phosphatase in patients with carcinoma of the prostate, including a large number with disease in Stages A and B. (In Stage A, foci of tumor are found incidentally at prostatectomy ...

In a compelling and articulate Special Article published in the Journal over three years ago, Fries¹ outlined a set of predictions indicating that the number of very old people would not increase, that the average period of diminished vigor would decrease,...

To the Editor: Several articles have presented evidence suggesting that human T-cell leukemia virus (HTLV) infection occurs in patients with acquired immunodeficiency syndrome (AIDS) and may have a causative role.^{1 2 3 4} HTLV is the only known human ...

No extract is available for articles shorter than 400 words.

To the Editor: General medical and nephrologic textbooks do not specifically address the potential diagnostic problem of separating simultaneous proteinuria and hemoglobinuria when hemolysis and renal disease may coexist.

We evaluated a 17-year-old white ...

To the Editor: In their report on the occurrence of humoral and cellular sensitivity to collagen in thromboangiitis obliterans, Adar et al. (May 12 issue)¹ have fully confirmed our findings on the occurrence of autoantibodies and cellular reactivity to ...

To the Editor: Over the past few years, these pages of the Journal have informed us of a barrage of new illnesses related to jogging. In this vein, it is interesting to note that when bicycling became the rage in this country in the 1890s a similar spate ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

Metallic lead was used in antiquity for water pipes, lining for baths, and food utensils. Lead salts were used as paint pigments, cosmetic pigments, and medicaments. Was exposure of aristocratic Roman families to lead the cause of the decline and fall of ...

These collections of medical tales for the public lend literal support to the old adage that you can't tell a book by its cover. Despite strikingly similar dust jackets, as well as overlapping titles and contents, the two works differ both in their ...

Here is a collection of 25 papers on research and clinical experience in a new and growing field. The work is organized into three major topic areas: assessment of disability, replacement of function, and reduction of handicap through computer technology. ...

Somewhere along the line, during the course of 19 editions dating back to 1939, Prof. Harper's original intention seems to have become sidetracked. As the title implies, this book is supposedly a review of biochemistry "providing a concise survey of those ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

Medicine

The Thalassemias. (Methods in Hematology. Vol. 6.) Edited by D. J. Weatherall. 166 pp., illustrated. New York, Churchill Livingstone, 1983, $32.

Urologic Cancer: Chemotherapeutic principles and management. (Recent Results in Cancer Research. Vol. ...

OCCUPATIONAL DISEASE

A workshop entitled "Chronic Disease in the Workplace and the Environment" will be held at the Shoreham Hotel in Washington, D.C., October 31-November 1. The fee is $40.

Contact the Foundation for Occupational Disease Research, Rm. ...

A growing number of states, governed by chief executives with a variety of political perspectives, are moving forward to redesign their Medicaid programs, generally through changes that emphasize management of the care delivered and less freedom for ...