THE exact pathophysiologic mechanisms of unstable angina pectoris are unknown.¹ Coronary-artery spasm,^{2 , 3} increased coronary-artery tone,⁴ circulating platelet products,⁵ and prostaglandins⁶ may play a part. A nearly universal finding, however, is the ...

PAROXYSMAL nocturnal hemoglobinuria (PNH) is an acquired hemolytic anemia characterized by increased sensitivity of erythrocytes to complement-mediated lysis. The disease presents as a chronic hemolytic anemia of fluctuating severity, frequently ...

IT has recently been shown that the plasma proteins α₁-antitrypsin¹ and antithrombin III² share a similar structure, which arose by divergent evolution from a common ancestral protein some 500 million years ago.^{2 3 4} Both proteins are inhibitors of ...

PREVIOUS studies have suggested^{1 2 3 4 5 6} that maternal cigarette smoking influences the level of lung function in children. Most of these studies^{1 2 3 4} used analyses of cross-sectional data that left unanswered questions concerning the quantitative ...

IN the past 10 years ergot compounds, which selectively inhibit prolactin secretion, have been effectively employed in the treatment of hyperprolactinemia and related hypogonadism.^{1 2 3 4 5 6 7} More recently, it has become apparent that these drugs are ...

IN this study we report on the frequency of use of statistical techniques in the Journal to answer such questions as the following: Will knowledge of a few elementary statistical techniques, such as chi-square and t-test analyses, assist readers in ...

THE Anglo-American common law has traditionally been uncomfortable with scientific evidence. Great reliance has been placed on the lay jury system and partisan advocacy to provide justice. The result, however, is often a rather unstudied lack of reality ...

Presentation of Case

A 68-year-old woman was admitted to the hospital because of fever of unknown origin.

She was well until three months earlier, when she experienced abdominal discomfort. Several days later she found that her temperature was 38.3°C. She ...

Immunologic systems are now known to have a major role in the pathophysiology of many human disease processes. One such system is serum complement. Complement is one of several plasma protein systems that consists of a series of circulating precursor ...

Hemorrhage resulting from genetic defects in the blood coagulation system represents one of the most dramatic clinical emergencies. Study of these disorders has led to effective approaches for both the control and prevention of bleeding episodes and to ...

In a recent Sounding Board article on health-care costs, Ginzberg defines true cost containment as "a reduced inflow of real resources into the health-care system without a diminution in useful output that would adversely affect the satisfaction of ...

No extract is available for articles shorter than 400 words.

To the Editor: Afrin nasal spray is among several over-the-counter long-acting nasal sprays or drops containing 0.05 per cent oxymetazoline. From animal experiments oxymetazoline has been shown to stimulate central alpha-adrenoceptors and thereby produce ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

Coronary-artery bypass operations were introduced in 1967. For 15 or 16 years they have been as intensively studied and analyzed as any therapy of past centuries. There was unbridled enthusiasm for this operation in the early 1970s. Then, as early results ...

Only the title of this book is off target. It is not primarily a book about coronary-artery disease, but about coronary-artery defects in infants and children. The foreword states, "A new outlook on coronary diseases in adults postulates that the disease ...

No extract is available for articles shorter than 400 words.

For several decades simple cardiac ventricular pacing has provided the major application for clinical electrophysiology. We are now entering an era in which electrical rewiring of the heart is assuming therapeutic importance. Cardiac pacing now requires ...

No extract is available for articles shorter than 400 words.

In the eagerly awaited third edition of Abrams' Angiography, the editor and a highly talented group of angiographers document the steady growth of angiography since the 1971 edition of this monumental reference work.

Of the 107 chapters in the three-...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

A task force* at the University of California, San Francisco, has developed infection-control guidelines for patients with the acquired immunodeficiency syndrome (AIDS). The task force included representatives of the University of California, San ...