Multiple sclerosis is one of the most common causes of chronic neurologic disability in young adults.¹ The pathologic process consists of demyelination of Central-nervous-system white matter, in association with inflammation and gliosis. Although the ...

The observation that the immunosuppressive action of hyperbaric oxygen may ameliorate experimental allergic encephalomyelitis^{1 2 3 4 5} has created renewed interest in the use of hyperbaric oxygen in patients with multiple sclerosis. In 1958 Layton and ...

The unfavorable prognosis of chronic renal failure in systemic lupus erythematosus has been well documented.^{1 2 3} For many years hemodialysis was not routinely recommended for patients with end-stage renal disease secondary to lupus nephritis, because of ...

Since the first poison center was established in Chicago nearly 30 years ago, the number of such centers in the United States has grown to over 400.¹ This tremendous growth has occurred haphazardly, with little effort to standardize the quality of ...

Antidepressant Agents

It is important to detect depression in the elderly, since it is often responsive to treatment and since suicide is common in this age group, especially among depressed white widowers.^{3, 76} Other risk factors for suicide that are ...

Resistance to antineoplastic drugs may develop through a variety of mechanisms, including deletion of membrane-transport mechanisms, an increase in target-enzyme concentration, or a deletion of an essential drug-activating enzyme. One unique mechanism for ...

The bacterium Listeria monocytogenes is a motile, gram-positive coccobacillus that can frequently be isolated from soil, water, and vegetation. It is a common cause of meningoencephalitis and abortion in ruminants, but it is infrequently identified as a ...

Presentation of Case

A 15-year-old girl was admitted to the hospital because of a murmur and a right ventricular mass.

The patient was the third child of a mother 44 years of age; she was born of a normal pregnancy, labor, and delivery. Her growth, ...

No form of treatment has been demonstrated to alter the long-term course of multiple sclerosis. This is not because of lack of effort. From Charcot's time up to the present issue of the Journal,^{1 , 2} trials of hundreds of various treatments have been ...

This issue of the Journal includes two articles^{1 , 2} and an editorial³ concerning new approaches to the treatment of multiple sclerosis. The events surrounding the publication of the paper by Dr. Fischer and his colleagues are worthy of comment here. Even ...

Physicians who treat patients with systemic lupus erythematosus have long been aware that in those who reach a stage of advanced azotemia, remission of the nonrenal features of the illness and improvement in the serologic abnormalities frequently occur. ...

Regional poison-control centers had their genesis in the mid-1950s and finally became a reality after more than 20 years. Recovery of the consumer market after World War II was associated with a proliferation of new chemicals, insecticides, pesticides, ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

To the Editor: The current leading etiologic candidate for acquired immune-deficiency syndrome (AIDS) is a new infectious agent.¹ However, it is unlikely that this complex syndrome is the result of a single factor, and investigators of AIDS should ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

To the Editor: Phenytoin and quinidine have been used in combination to treat ventricular ectopy. Phenytoin is known to increase the metabolism of quinidine by inducing hepatic microsomal enzymes.^{1 , 2} In spite of this fact, there are only rare clinical ...

No extract is available for articles shorter than 400 words.

To the Editor: I am writing to offer a patient's view of a practice seen increasingly in medical circles: addressing patients by their first names.

Three recent incidents come to mind. I am in the radiology waiting room of a wellknown Buffalo hospital. A ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

This is the second edition of a book published in 1975 that has since become an important reference work. It is said that with a second edition, textbooks begin their several stages of maturity. This book is no exception. With this revised and improved ...

No extract is available for articles shorter than 400 words.

This book aims to provide the obstetrician/gynecologist with a working knowledge of clinical genetics. That the authors are experienced is evident from the numerous references in the text to their own previous works. The stated purpose here is to survey ...

There is a place for textbooks of this size and format in most disciplines of medicine. The larger books, such as those in surgery (examples are the textbooks edited by Sabiston and by Schwartz), have grown to the point where they cannot be carried about. ...

Here, the editor has admirably fulfilled his goal of compiling a book primarily for the practicing neurosurgeon. It is a well-produced work with adequate illustrations, figures, and tables. The reproductions of the radiologic examples are only fair, but ...

When the history of hip surgery in the United States is written, an important and lengthy chapter will be devoted to the "Boston School." The vigorous, innovative, and entrepreneurial men who represent that group have had a profound impact on the ...

Several books on hand surgery have been published recently. Some have been written for a general audience and have attempted to deal with all aspects of hand surgery in greater or lesser depth. Others have been directed to a more narrow readership and ...

In an age when multiple authorship seems a prerequisite for a book on current practice, this work is a tour de force. Two authors, patently imbued with a common purpose and working in harmony, present a comprehensive and authoritative survey that is ...

Surgery

Essays on the First Hundred Years of Anaesthesia. Vol. 1 and 2. By W. Stanley Sykes. Vol. 1. 171 pp; Vol. 2, 187 pp., illustrated. Edinburgh, Churchill Livingstone, 1982. $20 per volume. [Reprint of 1960 edition.] (Distributed in the U.S. by Wood ...

TUMORS

A conference entitled "Diagnosis and Treatment of Common Human Tumors" will be held at the Hyatt Regency in Lexington, Ky., April 21–23. The fee is $25.

Contact Dr. John R. van Nagell, Jr., University of Kentucky Medical Center, Lexington, KY ...

Two years after assuming power, the Reagan administration has accomplished a number of the major health-policy goals it identified when Republican Ronald Reagan took office: it has introduced a more tight-fisted social contract between the federal ...