APLASTIC anemia is a life-threatening hematologic disorder characterized by pancytopenia and bone-marrow failure. In most cases the cause is uncertain, and several potential pathogenetic mechanisms have been implicated. Most data suggest that aplastic ...

THERE is a growing body of evidence to suggest that the impairment of nerve conduction velocity that has been observed in patients with diabetes mellitus is related to the abnormal metabolic state of these patients^{1 , 2} and, in particular, to the degree ...

SINCE June 1981, over 700 cases of acquired immune-deficiency syndrome (AIDS) have been reported to the Centers for Disease Control.^{1 2 3 4 5} The syndrome has been manifested clinically by Kaposi's sarcoma or opportunistic infections (or both) in ...

THE "human tumor stem-cell assay" has been proposed as an in vitro method by which anticancer drugs can be selected for activity against tumor cells from a patient. The method is analogous to sensitivity testing for antibiotics in patients with bacterial ...

ELDERLY persons (by definition, those 65 years of age and older) now make up about 11 per cent of the U.S. population, but about 30 per cent of all prescriptions are written for this group, primarily by internists and family physicians.^{1 , 2} Elderly ...

THE removal of inhaled particles, bacteria, and cellular debris by mucociliary clearance has an important role in the maintenance of healthy lungs. Particles are carried on mucus that is transported cephalad on the tips of beating cilia that are immersed ...

CIMETIDINE is a histamine H₂-receptor antagonist that is among the most widely prescribed drugs in the United States. In addition to its inhibitory action on gastric acid secretion, a possible role as an immunomodulator has been suggested.^{1 , 2} Isolated ...

Presentation of Case

A 60-year-old man was admitted to the hospital because of confusion and dysphagia.

The patient was well and working regularly as an accountant until several months earlier, when he began to make errors at work; he was ultimately ...

Recent developments suggest that the biochemical basis of diabetic polyneuropathy is now known, at least in broad outline. Polyneuropathy occurs in diverse hyperglycemic states that appear to have differing genetic and pathogenetic bases. The likelihood ...

One of the primary goals in caring for patients with malignant disease is to provide a treatment program that maximizes the chance of survival and minimizes the side effects of therapy. This goal is particularly important in chemotherapy for cancer.

In ...

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No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

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To the Editor: The variety of disorders with dystonia exceeds that of other forms of impaired motor control. Dystonic patients have involuntary, sustained muscle contractions and postures that can be extremely disabling. Certain dystonic conditions, such ...

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No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

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To the Editor: Two forms of multiple carboxylase deficiency are recognized that lead to kctoacidosis and organic acidemia beginning shortly after birth and in early infancy, respectively.^{1 , 2} Both forms are associated with diminished activity of the ...

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No extract is available for articles shorter than 400 words.

To the Editor: We cultured fibroblasts from the nodule in the diseased palmar fascia and from the unaffected palmar skin of the same hand of 26 unrelated, randomly selected patients undergoing surgery for Dupuytren's disease. Five patients had bilateral ...

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No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

On October 31, 1981, the U.S. Public Health Service hospitals were closed, and one of the most colorful and productive eras in American medicine came to an end.

In many ways the history of the Public Health Service hospitals reflects the history of ...

Occasionally, when I tell physicians that I am a microbiologist, I hear comments like, "Oh, well, I forgive you!" This saddens me because I have a lifelong love affair with my science, having been bitten by the bug in a most predictable way when I read ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

The field of virology has become increasingly diversified in the past three decades. The contributions of tissue culture and molecular biology have enabled us to progress from phenomenology to an understanding of what these infectious agents are, how they ...

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Although it is not concealed in the same etymological cloak as dermatopathology or hematopathology, pulmonary pathology can confound many students and physicians with its polysyllabic and eponymous nomenclature. Until recently, H. Spencer's Pathology of ...

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Psychiatry and Psychology

Extraordinary Disorders of Human Behavior. (Critical Issues in Psychiatry.) Edited by Claude T. H. Friedmann and Robert A. Faguet. 314 pp. New York, Plenum Press, 1982. $35.

Tutorials on Motion Perception. (NATO Conference Series ...

NEUROLOGY FOR NON-NEUROLOGISTS

The sixth annual "Intensive Clinical Neurology Course" will be held at the Grand Hyatt Hotel in New York, March 25–27. The fee is $265.

Contact Dr. Lawrence P. Levitt, 1033 Hamilton St., Allentown, PA 18101: or call (215) ...