In 1967 Oberholzer¹ and Stokke² and their colleagues described children with life-threatening or lethal metabolic ketoacidosis in whom large amounts of methylmalonic acid accumulated in blood, urine, and cerebrospinal fluid. These children, and several ...

The widespread use of female hormones has resulted in numerous studies of the effects of oral contraceptives and exogenous estrogen on women's health. An increased risk of vascular diseases, such as venous thromboembolism, stroke, and myocardial ...

In a previous investigation we noted that herpes simplex virus (HSV) was the most common cause of nongonococcal proctitis in sexually active male homosexuals.¹ This paper presents the characteristic symptoms and signs and the histopathological features of ...

The suicide rate has been rising over the past 25 years, mainly among the relatively young.^{1 2 3 4 5 6} Studies of the different types of suicide have shown that suicide by means of firearms accounts for most of the rise.^{5 , 7} The purpose of this article ...

If we take as our standard of importance the greatest harm to the greatest number, then there is no question that malaria is the most important of all infectious diseases.

— Sir Macfarlane Burnet Natural History of Infectious Disease

In the 16 years ...

It should have been expected. There have been a number of contested divorce cases in recent years in which the wage-earning spouse has requested compensation for contributing to the partner's professional education during the marriage. If one agrees with ...

Raynaud's phenomenon may cause severe digital pain and functional disability, particularly in patients with underlying connective-tissue disease. The treatment of this condition is difficult.¹ Nifedipine, a slow calcium-channel antagonist, causes vascular ...

Cimetidine has been shown to be an effective drug for healing peptic ulcers and for preventing their recurrence.¹ In most clinical trials cimetidine has been associated with few side effects of clinical importance. Early toxicologic studies with ...

Presentation of Case

A 24-year-old man was admitted to the hospital because of cervical lymphadenopathy and the nephrotic syndrome.

He was in excellent health until one month earlier, when he noticed an enlarged, nontender left cervical lymph node. At ...

The disorders afflicting most Americans who commit suicide are depression and chronic alcoholism, one or the other of which has been present in the majority of suicides studied in this country.^{1 , 2} People who have other serious disorders — for example, ...

Weakened and frightened by illness, patients face an awesome barrage of medical information, technology, traditions, and jargon. Yet there is no other time when it is more important for them to participate in decisions about their medical care. No matter ...

To the Editor: Corbett et al. (Dec. 23 issue)¹ presented two cases of penicillin G-induced neutropenia. In 1981 we reported eight similar cases.² The patients had been treate intravenously with a total of 220 to 550 million IU of penicillin G (132 to 330 ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

To the Editor: Hess et al. reported their experience with local low-dose streptokinase in the treatment of peripheral arterial occlusions (Dec. 23 issue).¹ This report prompted us to use low-dose endobronchial streptokinase therapy in a critically ill ...

To the Editor: The antiarrhythmic drug amiodarone has received increasing attention over the past few years because of its proved efficacy in resistant forms of ventricular and supraventricular tachyarrhythmias.^{1 , 2} The pharmacokinetic and metabolic ...

No extract is available for articles shorter than 400 words.

To the Editor: Dr. Carleton B. Chapman's letter (Dec. 9 issue)* describes the rapidity with which the news of the invention of ether anesthesia reached publication in 1846, noting that only a month passed between the first clinical case and the printing ...

No extract is available for articles shorter than 400 words.

The emotional impact of pregnancy loss on women and their families is usually underestimated or unrecognized. Loss of a wanted pregnancy not only can have dramatic effects on a woman's self-image but dashes hopes and expectations for the would-be child. ...

This short, concisely written book deals primarily with the approach to patients with multiple congenital anomalies. In fact, it deals with the discipline of "syndromology," the study of disease entities composed of signs and symptoms that run together. ...

The first edition of this book appeared in 1960. The aim was to provide an up-to-date treatment (in full depth) of what was then known about the biochemistry and genetics of the inborn errors of metabolism. Since 1960, the subject has expanded at a rapid ...

This is a practical and useful book for pediatric neurologists and pediatricians. The authors achieved their aim "to develop ... a systematic clinical methodology" that will "facilitate clinical diagnosis," rather than "an endless array of factual data." ...

"One picture is worth more than ten thousand words." So goes the Chinese proverb. Nothing could be closer to the truth when oneis attempting to use papers or books to evaluate a patient whose diagnostic images suggest a syndrome. Although the diagnosis of ...

No extract is available for articles shorter than 400 words.

Neurology and Psychiatry

Disorders of Neurohumoral Transmission. Edited by T. J. Crow. 401 pp. New York, Academic Press, 1982. $58.

Handbook of Neurochemistry. Second edition. Vol. 2. Experimental Neurochomistry. Edited by Abel Lajtha. 475 pp., ...

OCCUPATIONAL AND ENVIRONMENTAL HEALTH

An "Occupational and Environmental Health Summer Institute" will be held in Tucson, Ariz., June 6-July 7. First- and second-year medical students will be given priority; medical students at other levels will be ...

No extract is available for articles shorter than 400 words.