PRIMARY biliary cirrhosis is a chronic inflammatory process involving the intrahepatic bile ducts that progresses to cirrhosis and frequently leads to death from liver failure or variceal bleeding. The cause is unknown, but there is much evidence for an ...

A PROLONGATION of the skin bleeding time associated with normal results on coagulation tests is the laboratory hallmark of the hemostatic derangement of uremia, indicating a defect in platelet-plug formation at the transected ends of blood vessels.¹ A ...

MYOCARDITIS is a poorly understood disease. Evidence of myocarditis has been reported in up to 10 per cent of routine autopsies,^{1 , 2} and electrographic and epidemiologic studies suggest that myocarditis occurs in 5 to 15 per cent of patients with common ...

A PREVIOUS article suggested some principles of medical-school education that were based on my second experience as a full-time medical student, undertaken after retirement from 35 years in academic medicine.* A curriculum fulfilling those principles is ...

ACUTE nonlymphocytic leukemia is an increasingly common complication of therapy with alkylating agents or ionizing radiation. Incidences as high as 5 per cent have been reported in patents with Hodgkin's disease who were treated with combined-modality ...

AORTIC-VALVE atresia associated with mitral atresia or stenosis, a diminutive or absent left ventricle, and severe hypoplasia of the ascending aorta and aortic arch make up a constellation of defects that was initially termed "hypoplasia of the aortic ...

CHRONIC inflammation can be associated with cancer.¹ Phagocytes in inflammatory lesions enzymatically reduce oxygen to reactive metabolites, which include Superoxide anions, hydrogen peroxide, and hydroxyl radicals. These reactive species kill ...

Presentation of Case

A 37-year-old woman was admitted to the hospital because of hypoglycemic episodes.

There was a long history of psychiatric problems, with multiple admissions to mental hospitals because of suicidal behavior, assaultiveness, and ...

IN this issue of the Journal, Mannucci et al. report that infusions of a synthetic derivative of antidiuretic hormone — l-deamino-8-D-arginine vasopressin (DDAVP) — shorten the prolonged bleeding time and prevent bleeding complications in patients with ...

For most physicians "myocarditis" means not only inflammation but also infection of the myocardium. Whether that meaning is correct or not, it is what the term suggests to most of us. Thus, when "myocarditis" is used to describe the heart in ...

IN the decade ahead, medical education in the United States will be governed more than ever before by inflexible economic imperatives. In the past century economic imperatives were overshadowed by reforms that centralized the education of physicians in ...

To the Editor: A profound disorder of immunity affecting primarily the male homosexual population is associated with opportunistic systemic infections, infections of the central nervous system, and unusual systemic neoplasms.^{1 , 2} We have now observed ...

To the Editor: During the past three years, a syndrome of severe opportunistic infection associated with immunodeficiency has been described in male homosexuals.^{1 2 3} Kaposi's sarcoma has also developed in some of these patients. The syndrome has been ...

No extract is available for articles shorter than 400 words.

To the Editor: We write out of serious concern for what we believe is an inappropriate recommendation of Marx et al. (August 12 issue)* that familial hypercalcemia with hypocalciuria, relative to urinary calcium levels in a majority of patients with ...

To the Editor: Textor et al.¹ are to be commended for their observation that renal perfusion was preserved during beta blockade with nadolol in patients with hypertension, as well as their ingenious use of the ratio of renal blood flow to cardiac output ...

No extract is available for articles shorter than 400 words.

To the Editor: There is a plague loose upon the land that needs to be stamped out. It would be of no great importance except that it is a disease that interferes with communication and is highly contagious. It seems to have begun at the National ...

No extract is available for articles shorter than 400 words.

To the Editor: Induced abortion has been legal in Italy since 1978, may be performed only in hospitals or authorized clinics, and is free of charge during the first 90 days of pregnancy. Women who seek an abortion must obtain a doctor's certificate and ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

To the Editor: I don't know whether all your readers have noticed it, but we are in an age of depersonalization of everything. We tend not to know our neighbors personally anymore. We no longer sit on front porches and visit. We no longer walk the ...

Whenever societal concern is heightened regarding the abuse of psychoactive and addicting drugs, a concomitant although usually less strident concern is expressed that these drugs may be inappropriately withheld from patients who would benefit from them. ...

This is a complex subject of growing importance to physicians, hospital directors, insurance executives, organized labor, and industry. Variations in hospital use have been described for years, but most of the published papers have been in journals, ...

With increasing government regulation of medical care, a surfeit of malpractice claims, and the growing sophistication of the public, practicing physicians find themselves in an increasingly controlled environment. Several newly organized bodies are ...

Expenditures for nursing-home care have grown faster than outlays for any other type of medical care since the enactment of Medicare and Medicaid. In 1979 total expenditures for nursing-home care were over $17.8 billion, and the government's share was ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

Although emergency medicine has gained grudging acceptance as a bona fide certifiable specialty, and the term "ER" has been superseded by "emergency department," acute-care medicine remains near the bottom of the pecking order at hospitals and medical ...

No extract is available for articles shorter than 400 words.

SPORTS MEDICINE

The "Sports Medicine Conference" of the University of Vermont College of Medicine will be held at the Sugarbush Inn in Warren, Vt., February 13–18. The fee is $300.

Contact Continuing Medical Education, 235 Rowell, University of Vermont, ...

These guidelines are in accord with the "Uniform Requirements for Manuscripts Submitted to Biomedical Journals." (The complete document is available in the June 12, 1982, issue of the British Medical Journal and the June 1982 issue of the Annals of ...