A CAUSAL relation between hyperglycemia and microvascular complications of diabetes is strongly suggested by animal studies, but the available clinical studies are inconclusive.^{1 2 3 4 5 6 7 8} Conventional modes of subcutaneous insulin therapy have failed ...

IN 1978 Portmann and his colleagues described the presence of striking orcein-positive deposits of copper-binding protein in liver-biopsy specimens from patients with Indian childhood cirrhosis.¹ Subsequent studies confirmed the presence of elevated liver ...

IN 1966 Leland Clark and Frank Gollan dramatically demonstrated the oxygen-carrying capability of perfluorochemicals with the survival of mice completely immersed in a fluorocarbon liquid.¹ Since then, stable, inert aqueous emulsions of perfluorochemicals ...

THE causes of peripheral neuropathy are multiple.¹ Because of a better understanding of the natural history of the peripheral neuropathies, improved approaches to detection and characterization, and improved classification, it should now be possible to ...

THE goal of pharmaceutical research is to find drugs with desirable therapeutic properties and low risks of undesirable side effects. Drugs with such high therapeutic ratios are usually sought as new chemical entities — molecules designed to produce the ...

THE hyperimmunoglobulin E recurrent-infection syndrome (HIE), also known as Job's syndrome, is a disorder of unknown cause characterized by high levels of circulating IgE, a leukocyte chemotactic defect, and recurrent skin and sinopulmonary bacterial ...

REPORTS of the preoperative localization of gastrinomas by percutaneous transhepatic venous sampling^{1 , 2} have been published, but the data are scanty. Successful identification of a solitary and sporadic nonfamilial gastrinoma may dictate surgical ...

Presentation of Case

A 49-year-old man was admitted to the hospital because of dyspnea and syncope.

He was well until three months earlier, when dyspnea developed abruptly while he was walking up a short hill, and he lost consciousness briefly. He entered ...

For many years a search has been under way for oxygen-transporting materials that can be used in blood replacement. At one time it was natural to consider hemoglobin the only practical solution to this problem. Hemoglobin preparations free of insoluble ...

There is a growing body of opinion that all patients with hypertension — no matter how mild or uncomplicated — should be treated. In a recent report to Congress, the Assistant Secretary for Health, Edward N. Brandt, Jr., stated that the Hypertension ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

To the Editor: The paper by Woods et al. (March 11 issue)¹ provides additional support for the proposal by Canessa et al.² that overactivity of the red-cell transport pathway mediating sodium–lithium exchange may be a genetic marker for essential ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

To the Editor: Iglehart recently reviewed the role of business in health care (January 14 issue),¹ referring to the Sapolsky report² to support the contention that companies are reluctant to become involved in health-care issues. Iglehart did not discuss ...

ON March 17, 1982, fourth-year medical students throughout the United States received the results of the National Residency Matching Program (NRMP). This system has worked effectively for 30 years, and more than 90 per cent of senior students participate ...

The saga of the search for the cause of kuru is unique in contemporary science. Sophisticated resources were deployed to examine a fatal Central-nervous-system disease occurring in Stone Age cannibalistic tribes in the isolated highlands of New Guinea. ...

No extract is available for articles shorter than 400 words.

Today, "Walter Reed" is a hospital, a research institute, or — for those with some historical interest — "something to do with yellow fever." The man has disappeared into the mists of time.

The biographies of Reed by Kelly (1906), Truby (1943), and Wood (...

The life of Wilder Penfield (1891–1976) had all the elements of romance and high purpose that a biographer could require. A lad raised in the frontier days of Spokane, spurred on by his pious, strong-willed mother, was able to excel in football at ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

The recent explosion of information on the role of peptides in the function of the central nervous system has been at the same time awesome and intimidating. Many of the distinctions between endocrinology and neurology have now become so blurred that they ...

Something of a sequel to Life After Death, this book provides counterpoint to our renewed awareness of dying as a living event. The title is misleading, for, as the author (a University of Florida cardiologist) is careful to point out, the subject matter ...

Basic Science

Biological Mediators of Behavior and Disease: Neoplasia. Edited by Sandra M. Levy. 260 pp. New York, Elsevier/North-Holland, 1982. $48.

Biological Substances: International standards, reference preparations, and reference reagents, 1982. ...

THE INTERNATIONAL SKELETAL SOCIETY

The Society will offer its 9th Annual Refresher Course on Musculoskeletal Disorders at the Hyatt Union Square Hotel in San Francisco, September 1–4. The fee is $350.

Contact Renee Sauers, Radiology Postgraduate Education,...