When the study described below was designed in 1972, there were persuasive arguments for the prophylactic use of beta-adrenoceptor antagonists in patients who had recovered from myocardial infarction. The abilities of these drugs to attenuate sympathetic ...

Chronic active hepatitis is the histologic expression of a variety of distinct disease states, including hepatitis B and non-A,non-B virus infections,^{1 , 2} drug reactions,³ Wilson's disease,⁴ alpha-1-antitrypsin deficiency,⁵ and alcoholic liver disease.⁶ ...

Microvascular permeability to small and large molecules is increased in patients with long-term diabetes.^{1 2 3 4 5 6} The enhanced leakage has been demonstrated by the rate of escape of labeled albumin² and by local clearance methods using various tracer ...

We undertook a collaborative study to estimate the potential costs and benefits to society of implementing a national program to screen donor blood for elevated levels of serum alanine aminotransferase (ALT). Two other recent studies, the Transfusion-...

Systematic and persistent differences have been documented in the standardized rates of use for common surgical procedures in the United States and the United Kingdom,¹ as well as among the political subdivisions within these countries, such as states, ...

Pernicious anemia appears to be more common in blacks than was formerly recognized, but some features of the disease appear to differ in blacks and whites. For example, among blacks there is an earlier age at onset, a greater frequency of serum antibodies ...

When isoniazid, a drug used in the treatment of tuberculosis, is given to patients receiving phenytoin, phenytoin intoxication develops in some patients with the slow-acetylator phenotype.¹ This interaction is presumably a result of isoniazid's ability to ...

Presentation of Case

A 42-year-old right-handed woman was admitted to the hospital because of headaches and papilledema.

There was a 20-year history of bilateral frontal headaches, which radiated to the occiput. Six months before admission frontal and ...

Diagnostic tests and procedures serve many purposes. They screen for the presence of occult disease. They help to confirm some diagnoses and reject others. Occasionally, they uncover diagnostic possibilities that would explain elusive symptoms. Once ...

The practicing physician ordinarily has little specific impact on the decision to market a drug. Before regulatory approval, the research on a new drug is conceived, executed, and evaluated by a complex chain of industrial, academic, and regulatory ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

To the Editor: I wish to report a case of anaphylactic hypersensitivity to diethyl-meta-toluamide (DEET), a topically applied insect repellent.

After a game of tennis, a 42-year-old woman with no prior atopic history touched a companion who had just ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

To the Editor: High-dose intravenous metoclopramide has been reported to be an effective antiemetic for patients receiving cisplatin.^{1 , 2} Metoclopramide is generally considered to be a safe drug with infrequent side effects that are predominantly ...

No extract is available for articles shorter than 400 words.

To the Editor: The use of positive end-expiratory pressure (PEEP) during ventilator therapy for acute exacerbation of symptoms in chronic obstructive lung diseases has received little attention. Small increments of PEEP (up to 6 to 8 cm H₂O during ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

Consider the stages of a hospital admission. The first few days are fraught with questions. The physician labors over professional questions: "Have I elicited all the pertinent history? Have I picked up the relevant physical findings? What about the logic ...

This videotape documentary was independently produced for presentation to the general public. It purportedly will "help the people focus and articulate their concerns about changes in the medical profession." Such distinguished physicians as Paul Beeson, ...

No extract is available for articles shorter than 400 words.

This work is an interesting history of publicly owned general hospitals in metropolitan areas of the United States. City and county hospitals have faced a variety of challenges since their inception in the early 19th century. Today they are embroiled in ...

Readers who were connected with the Harvard Medical Services or the Thorndike Memorial Laboratory at Boston City Hospital will find memories of stimulating times returning with a rush as they read Finland's remarkable account. Many former members of the ...

The principal thesis of this book is that whereas the determinants of health fall into four classes (biology, environment, life style, and health-care organization), it is in the second and third categories that the community, through health education and ...

A review of these two books leads to an inescapable conclusion: Medicaid — notwithstanding all the criticism directed at it because of escalating costs and program inefficiencies — has become the cornerstone of health care (and thus of health policy and ...

In Rachel Weeping the provost of Notre Dame University describes how he came to his position that abortion is a "savage crime." In a series of five essays he examines the abortion issue from several perspectives. The first essay is based on books by two ...

The receipt of these books is acknowledged, and this listing must be regarded as sufficient return for the courtesy of the sender. Books that appear to be of particular interest will be reviewed as space permits.

The Journal solicits reviews of new ...

READING BY BERTON ROUECHé

A reading by Berton Roueché, author of the "Annals of Medicine" series in The New Yorker, will be held at the Massachusetts Institute of Technology, Room 6–120, Cambridge, on November 30 at 7:30 p.m.

Contact Dr. Barbara Gastel, ...