The Eurotransplant Foundation was started in 1967 with the idea that, in spite of the enormous polymorphism of the HLA system, good histocompatibility matches could be accomplished if unrelated kidney donors were matched against a large pool of potential ...

Acetylsalicylic acid, an inhibitor of platelet cyclooxygenase, is known to cross the placenta after ingestion by the mother¹ and has been associated with abnormalities of hemostasis in both the full-term² and the premature infant.³ However, in the studies ...

The rationale for combining surgery and chemotherapy in the treatment of melanoma was developed from new concepts derived from studies in animals, which showed that the efficacy of chemotherapy is inversely related to the total tumor-cell burden. ...

The Development of Orphan Products

Considerable attention has been directed in recent years to the plight of the patient with an uncommon disease for whom a drug or device with demonstrated or potential effectiveness remains unavailable because of a lack ...

The post-revolutionary period in America was one of restoring order after strife and, in Boston, freedom after occupation. The wounds of what became a civil war as well as a revolution were deep and slow to heal. It was not to be expected that discipline ...

The diagnosis of hypertrophic obstructive cardiomyopathy is based on a constellation of clinical and hemodynamic findings including left ventricular hypertrophy, asymmetric septal hypertrophy, small left ventricular cavity size, systolic anterior motion ...

Acute cardiac tamponade is a medical emergency that requires urgent therapy. Removal of pericardial fluid by pericardiocentesis or by open surgical drainage is effective,^{1 2 3} but delays may occur while the catheterization laboratory or operating room is ...

Chronic hypercapnia and daytime hypersomnolence in the obese patient without intrinsic lung disease — the so-called Pickwickian syndrome — has long been associated with periodic breathing.¹ The recognition that obstructive sleep apnea with functional ...

Presentation of Case

A 29-year-old woman was admitted to the hospital because of a question of a hepatic tumor.

She was well until three weeks earlier, when a dull ache developed in the right upper abdominal quadrant. One week before admission she awoke ...

A Pragmatic Beginning

As confidence wanes in both "regulation" and "procompetition" as panaceas to control health-care costs, even representatives of leading health-maintenance organizations are warning against competition.¹ However, the latest buzz word, ...

Two hundred years ago next month, the Corporation of Harvard College, which by then was already 146 years old, approved a plan to offer courses of instruction in medicine. A faculty was appointed, and in the autumn of 1783 medical lectures commenced in ...

Politicians and policy analysts are increasingly questioning the wisdom of current health-related tax subsidies. Two administration task forces have recommended reductions in the tax incentives for the purchase of health insurance.^{1 , 2} In Congress ...

No extract is available for articles shorter than 400 words.

To the Editor: The Journal is perhaps the scientific publication most closely observed and frequently quoted by the lay press, and the information contained in many of its articles is frequently interpreted for presentation to the public. Yet how ...

To the Editor: The study by Santosham et al.* of oral rehydration therapy of acute diarrhea in well-nourished children has proved such therapy to be effective. In this regard our observations may be of interest to your readers. In 1981, we treated 2051 ...

No extract is available for articles shorter than 400 words.

To the Editor: An editorial by Dr. Zelis (April 15 issue)¹ commented that diltiazem therapy had a low incidence of side effects, and recent randomized clinical trials support this statement.^{2 , 3} However, I wish to record four case histories that ...

To the Editor: Recently, a popular fishing magazine extolled the advantages of contact lenses instead of spectacles for fishing and boating.¹ This represents a dangerous notion, because fishing really requires the protection afforded by spectacles. The ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

Many physicians believe that use of the term "circadian" is one-upmanship — i.e., a new word for an old (and vexing) fact: diurnal variation. The authors document one of the reasons that prompted adopting this term (and others that describe "circa" ...

No extract is available for articles shorter than 400 words.

First-person accounts of illness are probably the commonest contribution to the general literature on coping with medical problems. In the Company of Others is a lively, well-written, intense (and occasionally strident) account of one journalist's ...

Despite its title, this book is not an emotional harangue about the injustice of contracting a potentially fatal disease. It is a well-written overview of current treatment for breast cancer written from a patient's perspective. Rose Kushner, by her own ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

The receipt of these books is acknowledged, and this listing must be regarded as sufficient return for the courtesy of the sender. Books that appear to be of particular interest will be reviewed as space permits.

The Journal solicits reviews of new ...

"LASER BIO-EFFECTS IN MEDICAL APPLICATIONS"

A course entitled "Laser Bio-Effects in Medical Applications" will be held in San Francisco, October 25–30. The fee is $700.

Contact the Education Director, Laser Institute of America, 5151 Monroe St., Toledo, ...