APPROXIMATELY half a million patients per year acquire urinary-tract infection in acute-care hospitals in the United States.^{1 , 2} Almost all nosocomial urinary-tract infections are associated with indwelling bladder catheters; many are asymptomatic. ...

PATIENTS who take an overdose of phenobarbital may have prolonged coma because of the long plasma half-life of phenobarbital (approximately 110 hours).¹ Methods of shortening the duration of coma by increasing the total body (systemic) clearance of ...

INFECTION with hepatitis B virus (HBV) causes substantial morbidity and mortality and contributes to health-care costs.¹ Unlike exposure to HBV in underdeveloped nations where HBV is endemic, exposure in industrialized nations occurs predominantly among ...

IT is now more than 30 years since Addis suggested that protein intake be restricted in patients with chronic renal insufficiency.¹ His aim was not to reduce uremic symptoms but rather to prevent an increase in the "workload" of surviving nephrons of ...

OVER the past 15 years research in virology has produced the first curative therapy for acute encephalitis, established a viral cause for five chronic neurologic diseases, and suggested a possible viral origin for a wide spectrum of other neurologic ...

AFTER our initial observation in 1978 of engraftment of nonfunctional intrauterine-derived maternal T cells in a patient with severe combined immunodeficiency without graft-versus-host disease,^{1 , 2} we prospectively examined all new patients with severe ...

HUMAN infection with Toxoplasma gondii may result from the ingestion of either the tissue cyst, which is found in certain meats, or the oocyst, which is shed in the feces of cats.^{1 2 3 4 5} Although epidemic toxoplasmosis is uncommon, a large outbreak of ...

Presentation of Case

A 69-year-old woman was admitted to the hospital because of a pulmonary mass.

She was well until five months earlier, when she began to experience fatigue and dryness of the throat. A physician heard an expiratory wheeze over the left ...

The mainstays of caring for patients who have swallowed poison or been given an overdose of drugs are inhibition of absorption (in acute poisoning after oral injection) or specific treatment (if any is available), enhancement of drug elimination from the ...

An inactivated subunit hepatitis B virus (HBV) vaccine was licensed in the United States in November 1981, and marketing began in June 1982. Before this vaccine was available, prevention of HBV infections depended mainly on environmental measures and on ...

Fuller Albright coined the term "pseudohypoparathyroidism" to describe hypoparathyroidism caused by target-organ resistance to the action of parathyroid hormone, as opposed to a simple deficiency of the hormone.¹ The resistance to parathyroid hormone in ...

To the Editor: In an interesting and important report in the February 11 issue, Crumpacker et al.¹ described the isolation of acyclovir-resistant herpes simplex virus from a patient treated with this promising antiviral agent. The virus induced less ...

No extract is available for articles shorter than 400 words.

To the Editor: I read with dismay yet another article suggesting that pK' in the H₂C0₃/HC0₃ ^- buffer system varies widely from predicted values in "acutely ill" patients (April 8 issue).¹ The evidence for this proposition is minimal. Although six ...

To the Editor: A 52-year-old man with end-stage renal disease from polycystic kidneys was being treated with long-term ambulatory peritoneal dialysis and was admitted because of a malfunctioning peritoneal catheter. Five months earlier he had undergone a ...

To the Editor: The letter of Murphy et al. (issue of March 26, 1981) reported briefly on the reaction of human epidermal Langerhans cells with the monoclonal antibody anti-T6, directed against a subset of thymocytes.¹ The same authors² as well as another ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

To the Editor: A common cost-containment strategy in hospitals is to select the least expensive drug from a group of agents largely equivalent in terms of efficacy and toxicity. First-generation cephalosporins (cephalothin, cefazolin, and cephapirin) and ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

Although mortality data indicate increasing life expectancies, some members of the public believe that the risks to individuals and society are growing. Both these books confront this apparent contradiction. They point out that satisfaction with the ...

For physicians and other health-care practitioners, this is a valuable contribution to a neglected area of study. It has been well edited by Harwood (an anthropologist) and is presented in a lucid, readable, yet scholarly style. Considering the strong ...

Arbitration in Health Care includes three distinct but related topics. In Part I, there is a discussion of the mechanics of arbitration, particularly as it relates to job grievances. Part II follows with a brief but clear discussion of different ...

BASEL LIVER WEEK 1982

Four seminars will be held during "Basel Liver Week 1982" in Basel, Switzerland, October 12–18,: "Bile Acids and Cholesterol in Health and Disease" (October 12–14); "Structural Carbohydrates in the Liver" (October 12–14); "Liver in ...

Public policy debates about genetic engineering have had three stages. The first, even before the modern molecular work was done, focused on the "chutzpah" of scientists and physicians who were willing to modify human lives and came from colleagues and ...