ACTIVATED platelets release free arachidonic acid from their membrane phospholipids, and arachidonic acid is then oxygenated by both cyclooxygenase and lipoxygenase. Cyclooxygenase, which is inhibited by aspirin and other nonsteroidal anti-inflammatory ...

THE clinical effects of infection in cutaneous leishmaniasis range from a single chronic ulcer to multiple lesions, with or without mucous-membrane involvement. Lesions may resolve spontaneously or persist for long periods, and the mucosal involvement can ...

GRAFT-VERSUS-HOST disease continues to be a major cause of morbidity and mortality after allogeneic bone-marrow transplantation.¹ Several methods have been used in attempts to prevent graft-versus-host disease, including methotrexate therapy after ...

THE recent Graduate Medical Education National Advisory Committee Draft Report¹ implies that if information on physicians' efficacy were available, the correct locational pattern for doctors could readily be calculated. In other words, if we knew the ...

ANXIETY is the distressing experience of dread and foreboding, with an array of autonomic concomitants (Table 1). The therapeutic benefits obtained from antianxiety medication, weighed against the adverse effects, have been a matter of considerable public ...

THE decrease in the fecundity of women who have passed a certain age is generally acknowledged, but supporting data on natural reproduction are scarce. (We use the term "fecundity" in the sense of "capacity for procreation"; "fertility" denotes actual ...

THE lack of normal B-cell differentiation in patients with acquired or congenital antibody deficiency may reflect abnormalities inherent in cells of B-lymphoid lineage or may involve abnormalities of regulatory (suppressor) cells.^{1 , 2} Circulating ...

SULFASALAZINE is used extensively to treat ulcerative colitis. Maintenance therapy with sulfasalazine decreases the frequency of relapse, and the drug has also been used to treat mild to moderate flare-ups of ulcerative colitis.^{1 , 2}

We report studies in ...

Presentation of Case

First admission. A 35-year-old man was admitted to the hospital because of an abnormal x-ray film of the chest.

He was in vigorous health until eight weeks earlier, when he began to experience constant substernal distress similar to ...

Bone-marrow transplantation is a promising therapy for a variety of hematopoietic and immunodeficiency diseases that are otherwise impossible to treat effectively. Indeed, more than 20 previously fatal diseases can now be successfully treated with bone-...

Parasitic infections, whether induced by protozoa (as in malaria and trypanosomiasis) or by helminths (as in schistosomiasis and filariasis) are among the most widespread and severe diseases of mankind. In the past 10 years, it has become increasingly ...

Fecundity, defined as reproductive potential, and its relation to age has become an important issue for many women. As a result of the changing roles of women, many are facing the question of whether to delay childbcaring until their 30s in exchange for ...

No extract is available for articles shorter than 400 words.

To the Editor: Because of its extensive first-pass metabolism (70 per cent),¹ lidocaine is generally considered to be relatively inactive when taken orally. We recently encountered a case of inadvertent ingestion of oral lidocaine with resultant ...

To the Editor: Ganguly et al. reported in the October 22 issue¹ on an anomalous postural aldosterone response in glucocorticoid-suppressible hyperaldosteronism (GSH). Since the absence of this response is also an indication of adenomatous primary ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

To the Editor: Haas,¹ Hall,² and Clarren³ and their colleagues have described a curious group of six infants, each with a hypothalamic hamartoblastoma (a very rare tumorous malformation) and a remarkably similar array of associated malformations, ...

To the Editor: Home dialysis was developed to provide dialysis for more patients at a time when funds were severely limited.^{1 , 2} Before the Medicare ESRD Program, it was common knowledge that home dialysis cost less than outpatient dialysis at a ...

To the Editor: The editorial by Laszlo and Lucas in the October 15 issue,¹ along with a recent review by Seigel and Longo,² shows that attention is being paid to the side effects of nausea and emesis as potentially limiting factors in some forms of ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

To the Editor: The concern about the cost of health care that pervades the thinking of policy makers in the United States in our day is not itself detrimental or ill-conceived. Use of human resources and material goods in a manner that benefits all ...

To the Editor: Conventional wisdom warns us against programming errors in computers. More wisdom suggests that we interpret Statistics with care. Nevertheless, scientists of all kinds have an implicit faith in the accuracy of preprogrammed calculators.¹ ...

The interest of the medical, neurologic, and psychiatric community in disorders of the hypothalamus and pituitary appears to have been uneven. There have been periods of rapid development in endocrinology (as in the 1930s and 1940s), causing general ...

Somewhere between 100,000 and 200,000 articles, monographs, and books have been written on the subject of schizophrenia since Blculer introduced the term 70 years ago. But try to find a modern, comprehensive, readable summary of what is known about ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

The main and only similarities between these two books are that they were compiled by physicians and deal with the impact of applied medical technology on the physician's role in the diagnosis and treatment of disease, in a strongly social context.

...

The receipt of the following books is acknowledged, and this listing must be regarded as sufficient return for the courtesy of the sender. Books that appear to be of particular interest will be reviewed as space permits.

The Journal solicits reviews of ...

ALBERT S. HYMAN FELLOWSHIP IN CARDIAC PACING

The Fellowship is available to persons who have the degree of Doctor of Medicine, Osteopathy, Philosophy, or Science, or equivalent training or experience in the field of biomedical engineering. The deadline ...