GLUCOCORTICOIDS such as dexamethasone can reduce the vasogenic edema associated with brain tumor and some other types of cerebral disease.¹ Since the 1960s they have been used extensively in cerebral malaria, on the assumption that cerebral edema is a ...

THERE is no effective treatment for primary biliary cirrhosis,^{1 2 3 4} a progressive and usually fatal liver disease in which hepatic copper concentrations are often as high as those in Wilson's disease.⁵

Because the cupruretic agent D-penicillamine is ...

FACTOR VIII/von Willebrand factor (FVIII/ VWF) in plasma has recently been shown by large-pore gel electrophoresis to exist as a series of multimers whose molecular weights have been estimated to vary between 1X10⁶ and 20X10⁶ daltons.^{1 2 3 4 5 6} Table 1 ...

THE practice of medicine in the 20th century has grown progressively more dependent on specialized tools that extend the clinician's powers of observation. Diagnostic procedures such as tissue microscopy, biochemical analyses of body fluids, radiography, ...

A 27-year-old diabetic man was admitted to the Toronto General Hospital in severe ketoacidosis after five days of nausea and vomiting.

The patient had had diabetes mellitus for 15 years and had been admitted to the Toronto General Hospital on five ...

SEVERAL drugs that inhibit the replication of herpesvirus in vitro are now being evaluated for the prevention or treatment of infections with herpes simplex virus and varicella zoster virus.^{1 2 3} Two of these drugs, acyclovir or 9-[(2-hydroxyethoxy)-...

PRIMARY amebic meningoencephalitis, caused by infection with the free-living amebas of the genera naegleria or acanthamoeba, was first reported in 1965 by Fowler and Carter in Australia.¹ Soon after that, the disease was reported in Eastern Europe² and ...

Presentation of Case

A 55-year-old man was admitted to the hospital because of jaundice.

He was well until 10 months earlier, when he noticed the onset of malaise. Eight months before admission he observed that his eyes were yellow. A physician made a ...

Brain edema accompanies a wide variety of pathologic processes and contributes to the morbidity and mortality of many neurologic diseases. It has a major role in head injury, ischemic and hemorrhagic stroke, and brain tumor. Edema also accompanies ...

It is now recognized that von Willebrand's disease, a disorder characterized by a long bleeding time and reduced factor VIII, is a frequent cause of a mild hemorrhagic diathesis.¹ Recent studies of the structure and function of factor VIII have provided ...

January 11, 1982, was the sixtieth anniversary of the first injection of exogenous insulin into a diabetic person. The discovery of insulin, credited to two University of Toronto scientists, Frederick G. Banting and Charles H. Best, was reported to the ...

DEATHS

Biron — Pierre Edouard Biron, M.D., of Beverly, died on October 12. He was in his 50th year.

Dr. Biron received his degree from the University of Ottawa School of Medicine in 1957. He was a member of the American Medical Association and the ...

To the Editor: During the 17 years since the Surgeon General's first report on smoking, intense research activity has been focused on the carcinogenic potential of the tar component of cigarette smoke. Only one definite chemical carcinogen — benzopyrene —...

No extract is available for articles shorter than 400 words.

To the Editor: Azathioprine is an antimetabolite and immunosuppressive agent primarily used to treat transplant recipients and patients with autoimmune diseases. It has been reported to induce a variety of perturbations of the immune system.^{1 , 2} Our ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

To the Editor: In a letter in the November 5 issue, Alperovitch and Feingold reported an increased sex ratio (male:female) among children of women with multiple sclerosis.¹ We have observed a remarkably decreased sex ratio in the offspring of young ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

To the Editor: The Special Article by Lowrie and Hampers¹ in the August 20 issue, discussing the Medicare End-Stage Renal-Disease (ESRD) Program from the viewpoint of "for-profit" dialysis units, was admirably complemented by the presence of the letter ...

To the Editor: H-Y antigen has been implicated in the regulation of testicular differentiation in mammals, and its appearance is generally correlated with the presence of the centromeric region of the Y chromosome.^{1 , 2} In human beings, exceptions to ...

No extract is available for articles shorter than 400 words.

To the Editor: Because of the scarcity of children for adoption in America, artificial insemination with a donor's semen (AID) is the principal means by which many infertile people here obtain the experience of parenthood, yet all too often this ...

No extract is available for articles shorter than 400 words.

The 1981 White House Conference on Aging (WHCOA), a gathering of some 3500 delegates and observers, was held in Washington in December amid lively controversy and some fast political action. The WHCOA is mandated by Congress to draft an agenda for each ...

It is estimated that 80 per cent of the nation's health-care resources are directed toward the care of the chronically ill. The scope of the problem extends beyond the delivery of health-care services. It challenges the commitment of society to sustaining ...

Probably the strongest and most cogent compliment that can be given to this book is that it fills a need. This is not meant to damn with faint praise: it is unfortunately a rare phenomenon in this era of aggressive publishers and willing editors. Feigin ...

No extract is available for articles shorter than 400 words.

In the past 10 years several good works on general orthopedics have been published. However, there are two areas that have not been addressed sufficiently: orthopedic problems in the newborn, and the basic science of the musculoskeletal system.

Hensinger ...

No extract is available for articles shorter than 400 words.

The editors of this book state that its purpose is to review what is known about the effectiveness of various methods of providing primary health care to children and to suggest revisions that will improve that care. The authors' basic premise is that any ...

This book contains much valuable information on writing, speaking, planning meetings, and preparing and using artwork, photographs, and other audiovisual aids. However, aspects of its content and style and perhaps its physical format limit its usefulness ...

No extract is available for articles shorter than 400 words.

The receipt of the following books is acknowledged, and this listing must be regarded as sufficient return for the courtesy of the sender. Books that appear to be of particular interest will be reviewed as space permits.

The Journal solicits reviews of ...

EMERGENCY CARE

Harvard Medical School will sponsor a workshop for emergency medicine physicians at Massachusetts General Hospital, May 10–21. The fee is $900.

Contact Barbara Wagner, Medical Education Unit, Massachusetts General Hospital, Boston, MA 02114;...