TRAUMATIC bone wounds of the distal leg are not uncommon¹ and continue to pose a formidable clinical problem.^{2 3 4} Ger has emphasized the merits of early coverage of bone in the prevention of septic sequelae in patients with extensive traumatic soft-...

NEONATAL severe primary hyperparathyroidism is a syndrome characterized by hypercalcemia, muscular hypotonia, skeletal undermineralization, and a high rate of mortality.^{1 2 3 4 5 6 7 8 9 10 11 12 13} In 1967 Mühlethaler et al. called attention to the fact ...

IMMUNE complexes that are shown by immunofluorescence examination to be present at the dermal-epidermal junction of specimens of normal-appearing skin are a characteristic finding in patients with systemic lupus erythematosus.^{1 , 2} Immunoglobulins and ...

THE severity of hemolytic anemia, vaso-occlusive episodes, and end-organ failure in sickle-cell anemia varies widely among patients with the disease. Possible determinants of such variation include hemoglobin F levels¹ and concurrent α-thalassemia.²

One ...

ONE effect of the changes in medical knowledge, science, and technology that have occurred in recent years has been an increase in specialization. Most physicians begin to limit their field of study in the first year of postgraduate training, although in ...

SINCE its introduction in 1970,¹ the flow-directed balloon-tipped (Swan–Ganz) catheter has gained clinical acceptance and increased usage for continuous monitoring of the hemodynamic status of severely ill patients. Among the complications occasionally ...

IN the course of a hemolytic disorder, episodes may occur during which reticulocytes virtually disappear from the blood, with the result that uncompensated destruction of red cells leads to progressively severe anemia. "Aplastic crises" were first ...

Presentation of Case

A 15-year-old boy was admitted to the hospital because of progressive dementia.

The patient was the first child of a 25-year-old mother, who had an uneventful pregnancy, labor, and delivery. His developmental milestones were normal. ...

Reconstructive surgeons now routinely use the muscle flap to cover a multitude of wounds complicated by bacterial infection and inadequate coverage. As early as 1946, Stark¹ reported the successful use of a pedicled muscle flap to close the wound of ...

A paradox has always troubled investigators of sickle-cell anemia. Although this disorder has been defined at the level of a single, specific nucleotide change in the genomic DNA and the corresponding amino acid substitution in the β-chain of hemoglobin, ...

Insufficient concern has been expressed about the development and incidence of unexpected adverse reactions to drugs given prophylactically over many years in attempts to reduce the risks of coronary and cerebrovascular diseases in predisposed but ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

To the Editor: Until recently, we followed the debate over the Ingelfinger Rule from a detached position. This changed abruptly when we were thrust into the center of the controversy by the actions of a science writer for the Denver Post.

The newspaper ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

COURSES AT THE MARINE BIOLOGICAL LABORATORY

The Marine Biological Laboratory in Woods Hole, Mass., will conduct a series of residential laboratory courses in the coming months: "Scanning Electron Microscopy in the Biological Sciences" (February 28-March 5)...

When I visited Poland in May and June of 1981, I was struck by the contrast between two strong forces that fed into the stream of Poland's daily existence: one, the great tide of enthusiasm over Solidarity's independent sweep into so many corners of ...