IN laboratory animals, both topically applied and systemically administered acyclovir has decreased the duration of viral shedding and accelerated the rate of healing of mucocutaneous, oral, and genital herpes simplex virus (HSV) infections.^{1 2 3 4 5} We ...

FOR the patient with hydrocephalus, surgical implantation of a shunting device offers a reasonable hope of permanent relief from the effects of increased intracranial pressure. With current ultrasound techniques, it is possible to make the diagnosis of ...

ALTHOUGH vasodilator drugs have proved useful in the treatment of patients with systemic hypertension and severe left ventricular failure, early experience with these agents in patients with pulmonary hypertension associated with normal left ventricular ...

TO evaluate published reports of clinical trials, readers need specific information about the methods used.^{1 2 3} However, such reports frequently omit important features of design and analysis.^{4 5 6} Mosteller and his co-workers⁷ found that investigators ...

IN 1824 Calmeil first described "grand mal" status epilepticus in his thesis, De l'Epilepsie.¹ He had observed patients who had repeated tonic-clonic seizures and did not recover consciousness between attacks. Fifty-two years later, Bourneville referred ...

EFFORTS to resuscitate the dead are as old as recorded history, and many techniques, including magic, ritual, and shamanism, have been employed.^{1 , 2} It is only in recent years that measures that regularly resuscitate patients from out-of-hospital cardiac ...

METABOLIC acidosis caused by D-lactic acid, the optical isomer of L-lactic acid, was recently described by Oh et al. in a patient with a short-bowel syndrome.¹ We encountered a similar condition in two patients with prior gut surgery. One patient had ...

Presentation of Case

A nine-year-old girl was admitted to the hospital because of virilization.

The child was born of a normal pregnancy and delivery to a mother aged 26 years, who took phenytoin sodium for epilepsy but received no other medication during ...

Patients ask whether acyclovir is a cure for genital herpes, and physicians want to know how they should use the drug. The article in this week's issue by Corey and his associates offers some answers to these questions.¹ No, topical acyclovir does not ...

This issue of the Journal contains a report by Packer et al. showing that hydralazine, a widely used systemic arterial vasodilator, did not produce consistent hemodynamic or clinical improvement in patients with primary or secondary pulmonary ...

The number of survivors of out-of-hospital cardiac arrest or sudden death has increased substantially in recent years. Emergency-care systems that promote bystander cardiopulmonary resuscitation, enable emergency medical technicians to arrive at the scene ...

The Special Article in this issue by DerSimonian et al. on "Reporting on Methods in Clinical Trials" is the first in a new series of articles on biostatistics that the Journal plans to publish over the next year or two. This series is the fruit of an ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

To the Editor: We read with interest the January 14 report by Fefer et al. on bone-marrow transplantation from an identical-twin donor during the chronic phase of chronic myelogenous leukemia.¹ We wish to report a successful marrow transplantation from ...

No extract is available for articles shorter than 400 words.

To the Editor: Since Cordero and Hon demonstrated that nasogastric suctioning could cause vagally induced cardiac arrhythmias or apnea or both,¹ the technique of airway suctioning for newborn infants has been modified to avoid "deep" suctioning until the ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

To the Editor: The CSII insulin pump in conjunction with home glucose monitoring can improve metabolic homeostasis in insulin-requiring diabetes mellitus, and pump systems have now been released for general use. To attain optimal benefit, however, ...

No extract is available for articles shorter than 400 words.

The editor's goal has been "the creation of a reference source for medical students, surgical residents, and surgeons in practice as well as teachers of surgery." The introductory chapters of this new edition emphasize the basic physiobiology needed for ...

No extract is available for articles shorter than 400 words.

An occasional and perhaps unfair comment is that anything new in diagnosing skeletal disorders can be found forgotten in the European literature. New textbooks should offer fresh perspectives or unique material. These authors have succeeded in both areas. ...

The title of this book will baffle many. Borrowed by the French from the Greek, the word "algodystrophy" evokes the dramatic counterpoint of ill-defined pain and dystrophic changes so characteristic of this enigmatic syndrome. Readers will recognize the ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

This book is the report of a panel of the National Institute on Alcohol Abuse and Alcoholism, assembled to analyze alternative policies for the prevention of alcohol abuse and alcoholism. The first part of the report provides a historical, conceptual, and ...

The receipt of these books is acknowledged, and this listing must be regarded as sufficient return for the courtesy of the sender. Books that appear to be of particular interest will be reviewed as space permits.

The Journal solicits reviews of new ...

MYCOPLASMOLOGY

The Fourth Congress of the International Organization for Mycoplasmology will be held in Tokyo, Japan, September 1–7.

Contact Wallace A. Clyde, Department of Pediatrics, 535 Bumett-Womack Bldg. #229H, University of North Carolina, Chapel ...

No extract is available for articles shorter than 400 words.