CYTOMEGALOVIRUS is the leading cause of congenital viral infection, with an average incidence of 1 per cent of all live births.¹ Clinically, this infection is largely inapparent in the neonatal period. It is estimated that only 5 to 10 per cent of those ...

SINCE their recognition in 1976,^{1 2 3} penicillinase (beta-lactamase)-producing strains of Neisseria gonorrhoeae have become highly prevalent in many geographic areas, including the Phillipines and parts of Asia and Africa.^{4 , 5} Although less than 0.5 per ...

BECAUSE the tricyclic antidepressants can be cardiotoxic after an overdose, their use has been considered potentially unsafe in patients with heart disease.^{1 2 3} This belief often presents a therapeutic dilemma, since depression frequently complicates the ...

SUDDEN death affects persons of all ages. In adults it is frequently the result of cardiac arrhythmia, especially ventricular fibrillation; in adolescents it is often accidental, and in infants, although it can follow arrhythmia or accident, it is ...

MORE than 99 per cent of the thyroxine (T₄) in blood is normally bound to specific plasma T₄-binding proteins, including T₄-binding globulin (TBG), T₄-binding prealbumin (TBPA), and albumin.¹ However, it is generally agreed that the concentration of ...

THE diagnosis of protein-calorie malnutrition is often based on objective measurements of nutritional status,¹ including assessments of hepatic secretory proteins (serum albumin and serum transferrin), anthropometric evaluation, creatinine-height index, ...

THE Williams syndrome is characterized by the triad supravalvular aortic stenosis, mental retardation, and an elfin facies.^{1 , 2} In addition, mild microcephaly, neurologic dysfunction, hallux valgus, hernias, pectus excavatum, and other congenital cardiac ...

Presentation of Case

A 63-year-old man was admitted to the hospital because of flank pain.

He was well until 13 years earlier, when peripheral edema developed. One month later he noticed impaired vision. On the following day he had a grandmal seizure and ...

IF a woman who has had a cytomegalovirus (CMV) infection has a recurrence of the infection during pregnancy, the chance that her baby will have a harmful congenital CMV infection is much less than it is if a woman has her first CMV infection during ...

IT is often difficult to define the relative importance of clinical appraisal and laboratory evaluation of the sick patient. Much of the education of a clinician concerns this need to assign relative weights to evidence and to know when less is ...

This issue of the Journal carries another chapter in the saga of the Anturane Reinfarction Trial. This report¹ presents the results of a special committee chaired by Dr. Bertram Pitt that was given the responsibility of reanalyzing in blinded fashion all ...

No extract is available for articles shorter than 400 words.

To the Editor: Most trials of prophylactic antithrombotic agents administered to prevent venous thrombosis and pulmonary embolism have studied surgical patients. Data on patients not undergoing surgery are much less plentiful, although many patients on ...

To the Editor: In the November 12 issue, Friedman et al. ¹ show that indomethacin produces coronary vasoconstriction. The authors used a large intravenous dose that they theorized would produce a blood level of 5 μg per milliliter, which they say is ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

To the Editor: Dzau and his co-workers reported in 1980 that converting-enzyme inhibitors, which block the conversion of angio-tensin I to angiotensin II, were effective in the long-term treatment of severe congestive heart failure.¹ Other groups have ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

To the Editor: The rectal use of metronidazole (Ioannides et al., December 24 issue¹) should remind physicians of a clinically efficacious but neglected alternative route for drug administration. I would like to report on the rectal use of an ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

To the Editor: More than two thirds of hospital-emergency-room users do not have a clinical emergency.¹ They could be cared for in less sophisticated, less expensive facilities. In our community, the average basic emergency-room charge for a nonurgent ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

(40 hrs. Category I CME credit.) Course directed by Peter F. Cohn, Eugene Braunwald, and Thomas W. Smith; edited by Stephen C. Schoenbaum. 20 audio cassettes; book of lectures (transcripts), 204 pp.; book of illustrations, 198 pp.; test for CME credit. ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

The number of cardiology textbooks seems to be increasing exponentially. Many are monographs on specific diagnostic procedures such as exercise testing or echocardiography. Some deal with therapeutic methods such as coronary-revascularization surgery. ...

No extract is available for articles shorter than 400 words.

One of the most important advances in cardiac surgery in the 1970s was the improvement in protection of the myocardium during valvular, coronary, and congenital-defect operations. A variety of techniques that had been originated during the pioneer days of ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

The authors' stated purpose for this book is "to uncover for interested physicians the concepts upon which recent progress and development in the formulization [sic] of diagnostic logic and the design of diagnostic models have been built. It describes ...

Basic Science

Advances in Neuroendocrine Physiology. (Frontiers of Hormone Research. Vol. 10.) Edited by K. B. Rut and G. Tolis. 140 pp. Basel, S. Karger, 1981. $58.75.

Basic Neurophysiology. By Beverly Bishop. 602 pp., illustrated. Garden City, N.Y., ...

PEDIATRIC HEMATOLOGY AND ONCOLOGY

A course entitled "Recent Advances in Pediatric Immunology, Hematology and Oncology" will be held in Erice, Sicily, May 2–9.

Contact Prof. Luisa Massimo, Department of Pediatric Hematology and Oncology, Istituto G. ...

The Anturane Reinfarction Trial, reported previously in the Journal, ^{1 , 2} was a randomized double-blind multicenter trial comparing the effects of sulfinpyrazone and a placebo on cardiac mortality after myocardial infarction. In this study, 1558 eligible ...