MANAGEMENT of ventricular arrhythmias remains problematic. A drug's failure to control arrhythmia may be attributed to inadequate antiarrhythmic activity, intolerable side effects, or compliance problems stemming from unfavorable pharmacokinetics.¹ These ...

FAMILIAL hypercholesterolemia is a disease characterized by elevated levels of low-density-lipoprotein (LDL) cholesterol, tendon xanthomas, and premature atherosclerosis.¹ Recently, Goldstein and Brown demonstrated a complete or partial defect of the LDL ...

SQUAMOUS-CELL carcinoma in situ of the vulva is appearing with increasing frequency.^{1 2 3 4} It is also appearing more commonly in women under the age of 40.^{3 4 5} It has been suggested that common pathogenic factors, possibly viral, may be associated with ...

THE objective of this review is to appraise the status of evaluation of the "efficacy," "effectiveness," "efficiency," and "availability" of neonatal-intensive-care programs. We will distinguish these terms below.

We define a neonatal-intensive-care ...

IN normal B-cell differentiation, the classes of surface immunoglobulin are acquired in a defined sequence. The earliest B cells bear surface IgM; as the cells mature they acquire surface IgD and sometimes IgA or IgG.¹ In the normal newborn almost all the ...

MITRAL-valve prolapse is a common disorder whose prevalence has been reported to be from 6 to 21 per cent in otherwise normal subjects.^{1 , 2} It is approximately three times more common in females than in males, and it appears in some instances to be ...

THE finding that the relative potency of a series of sympathomimetic amines varied with the effector organs or systems led Ahlquist in 1948 to conclude that there were two distinct types of adrenergic receptors, which he classified as a and β¹ The ...

Presentation of Case

A 16-year-old boy was admitted to the hospital because of confusion.

He was well until the early hours of the day of entry, when he was observed in a parked car having a seizure. When the police arrived he was wandering on a nearby ...

More than 93 per cent of the body's cholesterol is located in cells, where it performs vital structural and metabolic functions; only about 7 per cent circulates in plasma, where it predisposes to atherosclerosis. All the cholesterol in plasma is packaged ...

Squamous-cell carcinoma in situ (CIS) of the vulva is now being reported at an increasing frequency. Its association with cervical CIS and invasive cancer has been recognized, and a "field effect" has been proposed to explain cases of CIS of the vulva, ...

The first premature infant center was established in Chicago in 1923, and thereafter special-care units for the sick newly born have gradually appeared all over the world.

Since the crusade for regionalization of modern neonatal intensive care units (...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

To the Editor: Cis-diamminedichloroplatinum II (cisplatin) is an important anticancer agent that causes severe nausea and vomiting in most patients. Commonly used antiemetics have had little effect on the incidence of severity of these side effects, but ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

To the Editor: In the January 1 issue, Peterson et al.¹ present important information concerning the therapy for ethylene glycol poisoning. Although the general therapeutic strategy outlined is appropriate for this type of intoxication, the ...

To the Editor: One method through which health-maintenance organizations (HMOs) achieve their savings, as compared with physicians serving conventionally insured patients, is through decreased hospitalization.¹ Reduced hospitalization is also the measure ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

To the Editor: The Sounding Board articles concerning the Resident Matching Program (NRMP) in the May 7 issue^{1 , 2} prompted me to write about an entirely different problem inherent in the matching system. I became aware of this difficulty as a student ...

The many textbooks on anesthesia appearing in the past few years have made it difficult for the student of anesthesiology to know which to read. All three of the books reviewed here will benefit residents and clinicians and help them in providing better ...

No extract is available for articles shorter than 400 words.

Current estimates suggest that 50 million Americans have smoked marihuana and that 20 million use the drug regularly. The use of marihuana as an intoxicant does not, as the title of this book implies, extend from 10,000 B.C. Marihuana is only one of ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

Serologic and immunologic studies are important aspects of modern laboratory medicine. The specific methods now go far beyond the classic agglutination techniques exemplified by the sero-diagnosis of syphilis. Exquisitely sensitive immunoassays are now ...

No extract is available for articles shorter than 400 words.

Clinical Immunodermatology has succeeded remarkably well in presenting a concise account of the immune system and its role in diseases of the skin. Although the book seems to have been written primarily with office dermatologists in mind, I recommend it ...

No extract is available for articles shorter than 400 words.

The receipt of the following books is acknowledged, and this listing must be regarded as sufficient return for the courtesy of the sender. Books that appear to be of particular interest will be reviewed as space permits.

The Journal solicits reviews of ...

CLINICAL EPIDEMIOLOGY

A course entitled "Clinical Epidemiology" will be held at the Marina del Rey Hotel in Los Angeles on October 29 and 30.

Contact Dr. Noel S. Weiss, 4434 137th Ave. N.E., Bellevue, WA 98005; or call (206) 545–1788.

MEDICAL ETHICS

The ...