ALTHOUGH cytomegalovirus (CMV) is ubiquitous among patients with renal transplants,^{1 2 3 4 5 6 7} many questions remain about its clinical effects and importance. A central question is whether CMV infection can produce renal-allograft dysfunction. Some ...

HERPES-simplex-virus (HSV) infections are a major cause of morbidity after bone-marrow transplantation.^{1 , 2} A retrospective review of the experience at Johns Hopkins indicated that 45 (42 per cent) of 107 marrow recipients had HSV infections. The median ...

ALTHOUGH the ability of indomethacin to induce constriction of the symptomatic patent ductus arteriosus (PDA) is now established,^{1 , 2} there remain therapeutic failures that have yet to be given a rational explanation.^{3 4 5 6 7 8 9} Some infants have no ...

IN patients with chronic renal failure who are undergoing hemodialysis, arterial oxygen tension (PaO₂) falls when a dialysis solution containing acetate is used.^{1 2 3 4} It has been suggested that hypoxemia results from altered pulmonary ventilation-...

Jarndyce and Jarndyce drones on. This scarecrow of a suit has, in course of time, become so complicated that no man alive knows what it means.

—Charles Dickens

THE American courts continue to involve themselves — perhaps to become irrevocably entangled — ...

ONE of the basic challenges facing modern biomedical research is the understanding of how hormones produce chemical signals that cause alterations in cellular metabolism. Peptide hormones induce a host of responses in their target tissues through ...

Presentation of Case

A 60-year-old woman was admitted to the hospital because of lymphadenopathy and cutaneous nodules.

She was well until three years earlier, when she began to have episodic swelling of the face, which was usually limited to the lower ...

Persistent infections occur with all the human herpesviruses: herpes simplex virus (HSV) Types 1 and 2, cytomegalovirus (CMV), varicella zoster virus (VZV), and Epstein–Barr virus (EBV). In a persistent infection, the virus (or at least the viral genome) ...

The patent ductus-indomethacin controversy continues almost unabated. I am not certain that my advice on this subject ("Don't rush to the drugstore, yet") in a previous Journal editorial¹ has been heeded. I believe, though, that the level of healthy ...

Like so much else in medicine, the medical-book business is not only large but growing. The American Association of Publishers (AAP) reports that in 1969 1500 new medical books were published; by 1979 this figure had grown to 3200, and by 1980, to 3500. ...

To the Editor: We have reported that cultured fibroblasts from homozygotes and obligate heterozygotes for cystic fibrosis (CF) accumulated less ²²Na in the presence of ouabain than did normal cells.* In our original study, 32 different fibroblast strains ...

To the Editor: The report by Wiebers et al.¹ in the March 19 issue serves a useful purpose in emphasizing that size is the key variable in estimating the risk of future rupture of an asymptomatic and incidentally discovered aneurysm. The physics of ...

To the Editor: The report of Feely et al. (March 19 issue)¹ stating that cimetidine reduces hepatic blood flow is of considerable importance. In pilot studies of this hypothesis conducted more than a year ago, I could not find a consistent effect of ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

To the Editor: In the March 12 issue Kadin et al. described a new T-cell lymphoma characterized by tumor cells bearing Fc receptors for IgG (Tγ cells) that infiltrated the sinuses of the lymph nodes, spleen, and liver.¹ The tumor cells also showed ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

To the Editor: We read with interest the report in the February 26 issue by Rosenblum et al.¹ We have been following two patients with familial intrahepatic cholestasis (a boy, now 17 years old, and his sister, now 11) who had a similar progressive ...

To the Editor: The article by Couch et al. in the March 12 issue,* detailing 36 cases of surgical misadventures among patients at the Peter Bent Brigham Hospital, contained an erroneous statement of law in its final paragraph: "Often, a distinction can ...

Who is Walt and where does he live? — W.O.

With this terse telegraphic reply to a colleague's request for a consultation in 1886, William Osler began his relationship with Walt Whitman. That relationship was not an intimate one at first, nor did it ...

The receipt of the following books is acknowledged, and this listing must be regarded as sufficient return for the courtesy of the sender. Books that appear to be of particular interest will be reviewed as space permits.

The Journal solicits reviews of ...

MEETINGS OF THE AMERICAN COLLEGE OF PHYSICIANS

A list of the 1981 regional continuing medical education meetings sponsored by the American College of Physicians is now available.

Contact the American College of Physicians, 4200 Pine St., Philadelphia, PA ...