AS the treatment of hemophilia has become more successful, the management of bleeding in patients with antibodies to factor VIII has emerged as a major problem. Antibodies develop in about 5 to 15 per cent of patients with hemophilia A. These antibodies ...

SINCE its introduction for the treatment of seizures in 1938, phenytoin has remained one of the most widely used anticonvulsants. Perhaps the most severe and potentially life-threatening side effect of the drug is a rare idiosyncratic reaction ...

DRAMATIC improvements in the therapy of disseminated testicular cancer have been made during the past decade. Combination chemotherapy for germ-cell tumors with cisplatin, vinblastine, and bleomycin was initiated at Indiana University in 1974.¹ Thirty-...

IN 1977 a national survey in the United States estimated that almost 23.5 million persons were 65 years of age or older and that approximately 4.8 per cent were nursing-home residents.¹ As the population continues to age, each year more and more Americans ...

TWO decades have passed since Denis Burkitt, a British surgeon working in Uganda, originally described the tumor that now bears his name.¹ The discovery that this tumor has distinctive clinical and histologic features among the malignant lymphomas^{2 , 3} ...

CONVERSION symptoms are the relatively persistent losses or alterations in sensory or voluntary motor functioning that cannot be explained by known physical disorders or pathophysiologic mechanisms. Examples include paralysis, abnormal movements, aphonia, ...

Presentation of Case

A 58-year-old man was admitted to the hospital because of a cough, fever, and weight loss.

He was well until three months earlier, when he began to experience fatigue, malaise, anorexia, fever, chills, and night sweats, with a dry ...

There are about 12,000 patients in the United States with classic hemophilia. Most can be treated effectively with factor VIII concentrates, but about 15 per cent acquire specific inhibitors (antibodies) to factor VIII that may render replacement therapy ...

Among the technologic, economic, and cultural milestones of the past decade, one was scarcely noticed: The number of beds committed to nursing-home care in the United States surpassed the number of beds in acute-care hospitals.¹ Long-term care of the ...

During the past two decades, several reports favoring the institution of a federal system of no-fault compensation for injured research subjects have appeared.^{1 2 3 4} The proposals differ sharply on whether individual investigators, research institutions, ...

DEATHS

Bisgrove — John G. Bisgrove, M.D., of Danvers, died on June 30. He was in his 60th year.

Dr. Bisgrove received his degree from the University of Colorado School of Medicine in 1948. He was a member of the American Academy of Physical Medicine and ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

To the Editor: During last year alone, over 100,000 people ran marathons. Thus it is becoming important to appreciate that rather striking changes may occur in blood chemistry as a consequence of endurance training.^{1 , 2} Specifically, increased ...

To the Editor: Symptomatic foci of extramedullary hematopoiesis in the central nervous system have been reported in patients with agnogenic myeloid metaplasia, thalassemia, and cyanotic cardiovascular malformations.¹ We have observed a case of ...

No extract is available for articles shorter than 400 words.

To the Editor: Podolsky et al. (May 28 issue),¹ in evaluating test batteries that include galactosyltransferase isoenzyme II (GT-II) with one of the other recommended tests, have not specifically considered previously described principles of parallel-...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

Whether or not Norman Holter envisioned, two decades ago, that his new procedure for ambulatory electrocardiograms would later emerge as a multimillion dollar industry remains a moot point. The method continues to burgeon but with minimal guidelines ...

These two books differ markedly in purpose, content, and style but share a handicap: addressing a technology that has progressed so rapidly that publication lags behind current practice.

Evaluation of Cardiac Function by Echocardiography summarizes a ...

The black, formless design on the red cover of this conveniently sized paperback is the first item to stimulate the curiosity of the reader. Is it a Rorschach blot or a surrealist's view of the heart and circulation? On contemplation neither seems fitting ...

No extract is available for articles shorter than 400 words.

This atlas illustrates surgical techniques employed during operations on the esophagus, stomach, small intestine, and large intestine. The operative descriptions are augmented by brief discussions of the concepts on which the operations are based. The ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

More than a generation of English-speaking ophthalmologists have grown up under the literary guidance of Duke-Elder's 15-volume Textbook of Ophthalmology. Perhaps we shall never again see such a prodigious exposition of historic and scholarly material ...

The receipt of the following books is acknowledged, and this listing must be regarded as sufficient return for the courtesy of the sender. Books that appear to be of particular interest will be reviewed as space permits.

The Journal solicits reviews of ...

COURSES AT COLUMBIA UNIVERSITY

The College of Physicians and Surgeons of Columbia University will offer five courses in the coming months: "Ocular Inflammation, Diagnosis and Therapeutics" (September 24 and 25); "Advances in Surgical Pathology" (October ...

No extract is available for articles shorter than 400 words.