SINCE 1972 clinical trials have been carried out by the National Surgical Adjuvant Breast and Bowel Project (NSABP) to evaluate various regimens of adjuvant chemotherapy in women with primary breast cancer and positive axillary nodes. The first trial ...

Halsted radical mastectomy has been the treatment of choice for nearly 100 years in the management of breast cancer. Later modifications, such as the additional dissection of internal mammary nodes, have been gradually abandoned, whereas less mutilating ...

PHEOCHROMOCYTOMA endures as a life-threatening disorder.¹ The presence of a pheochromocytoma can now be safely and correctly established by the presence of clinical manifestations and abnormal hormone values in plasma or urine or both. Accurate ...

THE surface antigenic structure of hematopoietic cells changes during the course of differentiation from proliferating precursors to nondividing, functionally mature cells. In a given cell lineage, some antigens are expressed and others are lost during ...

THE antigen specificity of the antibody is determined by the variable (V) sequences of the hundred or so amino acid residues at the amino-terminal end of each of the heavy (H) and light (L) polypeptide chains of the antibody molecule (Fig. 1); the ...

IN 1964 Justin-Besançon and his co-workers described a new compound that depressed the vomiting center and stimulated gut motility.¹ Metoclopramide (Fig. 1) (methoxychloroprocainamide [RegIan]) resulted from efforts to alter the procaine molecule so that ...

Presentation of Case

A 66-year-old man was admitted to the hospital because of congestive heart failure.

He was well until two years earlier, when intermittent diarrhea developed. He was seen at the clinic, where examination was negative. Routine ...

Medical economics underwent a major metamorphosis when physicians' principal source of income shifted from the modest means of the average patient to the seemingly limitless insurance funds or tax dollars dispensed by an impersonal third-party ...

For many years the Board of Regents of New York State has set licensure requirements for graduates of foreign medical schools not accredited by the Liaison Committee on Medical Education; these requirements differ from those set for graduates of ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

To the Editor: The coagulation laboratory for the Hemophilia Center at Orthopaedic Hospital was established in 1967, and it immediately began clinical testing of factor VIII concentrates, performing factor VIII assays in patients' plasma obtained before ...

To the Editor: "Post-pump syndrome" is a well-recognized problem in patients who have undergone cardiopulmonary bypass. Both the capillary-membrane instability and the pulmonary edema observed in this syndrome are similar to those seen in other clinical ...

No extract is available for articles shorter than 400 words.

One might argue that an annual publication, like a chateau-bottled wine, is entitled to a "lesser" year. This year's volume of The Psychoanalytic Study of the Child is non-vintage. A group of knowledgeable and in some instances illustrious contributors ...

The first of these two books reviews the normal and abnormal behavioral development of physically handicapped children from infancy through adolescence. The main concerns are the abilities, motivations, and temperaments of the children, and the authors' ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

In the past 25 years the number of therapeutic trials has greatly increased, especially those studying treatment strategies designed to delay or prevent some adverse event. During this time, a great many new statistical methods have been developed for the ...

NEPHROTOXICITY

An "International Symposium on Nephrotoxicity" will be held at the University of Surrey in Guildford, England, September 7–11. The deadline for registration is July 15.

Contact the Secretary, Nephrotoxicity Symposium, Dept. of Biochemistry, ...

Manuscripts

Manuscripts containing original material (Original Articles, Special Articles, and brief reports in Medical Intelligence) are accepted for consideration with the understanding that neither the article, nor any part of its essential substance, ...