THE use of pump-oxygenator systems to facilitate open-heart surgery has been associated with a complex array of postoperative clinical sequelae, including coagulopathies; a systemic inflammation-like reaction that is characterized by increased capillary ...

THIS report is based on clinical, laboratory, and pathological data gathered over the past 15 years in seven children with chronic obstructive liver disease. In six of them an unusual and progressive neurologic syndrome developed. All the children had low ...

THE new administration could be the most fiscally constrained in half a century, and yet it must endeavor to provide full support to a revolution. That is the best word to describe the present state of the biologic sciences. Their economic foundation, ...

COMPLEXES of antigen and antibody (immune complexes) are capable of causing inflammatory injury.¹ Many human diseases can now be attributed to the presence of immune complexes in tissues. Some examples are systemic lupus erythematosus, acute and chronic ...

UNTIL recently, renal disease was considered a major cause of death among patients with gout.¹ Modern long-term follow-up studies of renal function, however, have indicated that hyperuricemia and gout rarely result in kidney damage unless other renal ...

BODY position may affect gas exchange by altering the matching of ventilation to perfusion within the lungs.^{1 2 3} In normal subjects breathing normally, both blood flow and ventilation are greater in the dependent lung zones. When subjects breathe deeply ...

PROPYLTHIOURACIL (PTU) is a mainstay of medical treatment for hyperthyroidism during pregnancy.^{1 2 3 4} PTU inhibits thyroid-hormone synthesis, extrathyroidal conversion of thyroxine (T₄) to 3,5,3′-triiodothyronine (T₃), and deiodinative degradation of the ...

Presentation of Case

A 42-year-old man was admitted to the hospital because of pain in the right lower quadrant of the abdomen.

He was well until 10 months earlier, when he was admitted to the hospital because of severe right-lower-quadrant pain. At ...

One of the earliest descriptions of gouty or hyperuricemic nephropathy was given by Todd in 1849, who found "in the pyramidal portion white streaks of a crystalline character consisting of urate of soda." ¹ The deposition of these crystals in the terminal ...

One of the more remarkable features of the lungs is the way in which alveolar ventilation is automatically adjusted to pulmonary-capillary blood flow as body position changes. Through this self-adjusting mechanism, the gaseous composition of arterial ...

In this issue of the Journal Cheron et al. report that modest doses of propylthiouracil (PTU) ingested by mothers being treated for Graves' disease significantly reduce serum thyroxine in newborn infants.

This finding is an important extension of previous ...

No extract is available for articles shorter than 400 words.

To the Editor: A lower ouabain binding at one hour in obese subjects, as shown in Figure 1 of the article by De Luise et al. in the October 30 issue, may be a consequence of slower ouabain binding (decreased affinity) rather than of fewer pump sites. It ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

To the Editor: The formation of N-acetylglutamate, which is a known activator of carbamylphosphate synthetase, is catalyzed in the liver by mitochondrial N-acetylglutamate synthetase. We wish to report on a hyperammonemic patient with a deficiency of ...

To the Editor: In his Sounding Board article in the November 6 issue, Dr. Oppenheim puts forward a series of assertions that seem to us to be unfounded. He claims that "Fascination with health maintenance is strictly American. It does not exist in ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

To the Editor: The report of the extensive investigation by Rudman et al. (September 18 issue) of hypocitraturia in patients with gastrointestinal malabsorption contains some errors pertaining to factors used to convert data and results, given in one ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

Over the past 20 years there has been a marked proliferation of services for developmentally disabled children. Children who formerly were not allowed in public schools are being included in all aspects of public education. Medical services are available ...

During the 1960s experts in government and the medical profession agreed that a "doctor shortage" existed and the supply of physicians should be increased. The federal government began to provide direct financial support for medical education. In 1980, ...

No extract is available for articles shorter than 400 words.

In the history of care of the mentally ill, one fundamental contradiction has always been present. Change over time in mental-health services can be viewed as a movement back and forth between the two poles of this contradiction. The contradiction is ...

Magnesium deficiency in human beings and animals is manifested by neuromuscular hyperirritability, incoordination, behavioral alterations, seizures, tetany, and cardiac arrhythmias, all of which are reversible by the administration of magnesium salts. ...

This monograph is the second in a three-volume series on metastasis; the series constitutes a major contribution to our knowledge of this important research and clinical area. Brain Metastasis follows a format similar to that of the first volume, ...

This collection offers an extensive view of the present status of neurotoxicology. The book comprises 64 chapters written by various authors and is divided into five sections. The first of the five, "Targets and Classification of Neurotoxic Substances," ...

Among the functions of epidemiology is to supply practicing physicians with helpful insights about ways to prevent disease. Epidemiology should provide information on which clinicians and health administrators can base policies and practices. ...

There are many different textbooks of cardiovascular disease, cardiovascular physiology, and cardiovascular pharmacology and other books that emphasize particular subspecialty interests within the spectrum of cardiovascular disorders. Braunwald's new book ...

The authors of this work have attempted to achieve several purposes and to appeal to diverse audiences. The book begins with a section on the classification and diagnosis of hypertension in pregnancy, followed by a presentation of the authors' studies on ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

This is a difficult book to review dispassionately: it could be dismissed as pseudoscientific balderdash or it could be hailed as bearing a message of hope. Both these approaches would be unfair. I will make a valid effort to reach a reasonable balance ...

The receipt of the following books is acknowledged, and this listing must be regarded as sufficient return for the courtesy of the sender. Books that appear to be of particular interest will be reviewed as space permits.

Education, Medical and Related

...

COLORECTAL CANCER

The Second International Symposium on Colorectal Cancer will be held at L'Enfant Plaza Hotel in Washington, D.C., on March 17. The topic will be "Risk Factors and Screening."

Contact Smith-Kline Diagnostics, P.O. Box 7929 (H21), ...