URINARY acidification may be impaired before and after relief of unilateral or bilateral urinary-tract obstruction.^{1 2 3 4 5 6 7 8 9} Studies in animals with experimentally induced obstructive uropathy have shown a transport defect in the distal nephron, ...

THE beneficial effects of corticosteroids in chronic active hepatitis (CAH) have been so well established in Australia, ¹ England, ² and America³ that this group of drugs has become the mainstay of treatment for CAH. The conclusions are so strong that ...

SINCE the introduction of mechanically controlled ventilation, it has been widely recognized that an increase in intrathoracic pressure is associated with a decrease in cardiac output and in arterial pressure.^{1 2 3 4} This adverse effect, however, usually ...

THE soaring cost of medical care has led to many efforts to contain expenditures. One of the most common proposals to reduce costs involves the substitution of ambulatory for inpatient care. In fact, it seems intuitively obvious that outpatient care ...

ACUTE infectious diarrheal illness is the leading cause of disease and death in many areas of the world. Indeed, by one estimate there were 3 to 5 billion cases of diarrhea accounting for 5 to 10 million deaths in Asia, Africa, and Latin America during ...

IN guinea pigs^{1 , 2} and mice, ^{3 4 5} the ability to develop humoral and cell-mediated immune responses to heterologous insulins is in part controlled by immune-response genes linked to the major histocompatibility complex. In human beings as well, genes in ...

Presentation of Case

A 55-year-old man was admitted to the hospital because of hemoptysis.

He was well until two years earlier, when hyper-tension was found, and hydrochlorothiazide was administered. Six months before entry a routine physical examination ...

Several kinds of tubular dysfunction can underlie renal tubular acidosis (RTA), a syndrome of disordered renal acidification that causes metabolic acidosis without (or with only a moderate) reduction in renal mass. Slowly developing and painfully ...

The liver disorder called chronic active hepatitis has been a vexing subject among clinicians and pathologists for over 20 years. Confusion and disagreement have often characterized attempts to define the terminology, pathological features, clinical ...

Controlled positive-pressure ventilation with added positive end-expiratory pressure (PEEP) is a major method of therapy for the severe hypoxemia associated with pulmonary edema, especially that associated with the persistent pulmonary edema caused by ...

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To the Editor: The review of my book Delirium: Acute Brain Failure in Man in the October 2 issue misrepresented its contents to such an extent that a clarification is required. The reviewer criticizes my definition of delirium as too broad and imprecise ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

To the Editor: Two problems raise grave questions about the conclusion of Biles et al. in the September 18 issue that state regulation of hospital rates has been effective in containing hospital costs. In the first place, the article focused on the ...

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No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

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Nearly half the infections in patients who have cancer with prolonged, severe granulocytopenia have been shown to be caused by hospital-acquired organisms that have colonized the alimentary canal.¹ Some acquired organisms are particularly virulent in the ...

This is a wonderful book. It is the 20th edition of the textbook initiated by Sir William Osler and first published in 1892. Osler originally conceived of a "Johns Hopkins Textbook of Medicine" written by Hopkins faculty, but after his death in 1920 this ...

These two books, both of which are intended for the nonspecialist, are as different as two books can be. Neither is likely to find a large audience in the United States — Meyer's book because it is poorly translated and structured and Hart's because it ...

The control of arterial pressure is one of the most precise, exquisitely delicate, and complex of the physiologic control systems. The avalanche of new knowledge has forced us to make a critical reevaluation of traditional physiologic concepts regarding ...

Years of clinical experience and comprehensive understanding of psychiatric illness have resulted in this masterly synthesis of contemporary psychiatric medicine by one of the clearest, best-organized scholars in the field. Principles of Clinical ...

In this compact but wide-ranging book, the authors, both of whom are on the staff of the Institute of Psychiatry at the University of London, present a general overview of some diverse areas of health care in which there is — or should be — an active ...

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Before the Second World War it was common for psychiatrists to have extensive training in neurology. Although a residue of this close relation can be found in a common specialty board, it is unusual for psychiatrists more recently trained to have had more ...

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The receipt of the following books is acknowledged, and this listing must be regarded as sufficient return for the courtesy of the sender. Books that appear to be of particular interest will be reviewed as space permits.

Surgery

Orthopedic

Total Knee ...

EMERGENCY CARE WORKSHOP

Harvard Medical School will sponsor a postgraduate course entitled "Emergency Care: An Extended Workshop." The course will be held at Massachusetts General Hospital, May 11–22. Applicants will be chosen in March. The fee is $800.

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