MANY studies of the function of the reticuloendothelial system have emphasized the critical role of the spleen as an efficient filter of blood-borne particles.^{1 2 3} Moreover, it is known that removal of the spleen predisposes a patient to the development ...

HYPERLIPIDEMIA, especially elevated levels of low-density lipoprotein (LDL), has consistently been identified as a major risk factor in coronary heart disease.¹ In persons with familial hypercholesterolemia, an autosomal-dominant disorder in which levels ...

SINCE 1970, approximately 75,000 patients throughout the world have undergone bioprosthetic valve replacement with glutaraldehyde-treated porcine heart valves mounted on flexible stents.^{1 , 2} These valves were developed primarily because of the risk of ...

ACADEMIC-practice plans have become increasingly important as a means of support for the faculty of academic medical centers and as a mechanism to combine the teaching of medical students and house staff with a private mode of medical care.¹ This report ...

THE calcium-lowering and phosphate-lowering hormone calcitonin was discovered by Copp et al. in 1962,¹ and it was soon viewed as a major calcium-regulating factor, along with parathyroid hormone (PTH) and vitamin D.² However, the lack of clearly definable ...

CIRCULATING high-molecular-weight forms of many polypeptide hormones have been described, but there have been few reports of their occurrence as the predominant forms of glycoprotein hormones.^{1 2 3 4 5 6 7 8} This paper describes the presence, in a healthy ...

Presentation of Case

A 56-year-old man was admitted to the hospital because of hypoglycemia.

There was a long history of alcohol abuse, with delirium tremens and hepatic disease. Eight years before admission a left pleural effusion developed, and a ...

This issue of the Journal contains a detailed review by Cohn et al. of a group of patients who underwent porcine bioprosthetic heart-valve replacement. Is the authors' final sentence ("Even with the uncertainty of long-term durability, if the risk of ...

The era of large, full-time clinical departments in our medical schools began soon after World War II with the rise of the subspecialties and the rapid expansion of clinical research. Before then, most medical schools had relatively small full-time ...

Identification of phenylketonuria (PKU) in the newborn by routine screening depends on the presence of an increased concentration of phenylalanine in the blood when the specimen is obtained. In infants with PKU, phenylalanine is not substantially ...

To the Editor: Diana Paul has made a relevant but problematic point in her letter in the October 23 issue. As a genetic counselor coordinating a substantial amniocentesis program, it is apparent to me that the issue of "amnio before 35" is becoming a ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

Like other volumes in this series, the express purpose here is to explore gerontologic aspects of a specific category of diseases. The focus is on rheumatic disease, and the editors have set out to cover the basic-science and clinical aspects of aging and ...

Old people, especially those in nursing homes, are commonly given hefty doses of various psychoactive drugs to cause them to sleep, make them less depressed, or render them more tractable. However, many consider the therapeutic use in the aged of one time-...

No extract is available for articles shorter than 400 words.

This book is a collection of essays, the first of which has given the book its title. The author of the book has had a long literary career; his books include well-known works on senility as well as writings on relations between biology and the arts. His ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

This book is not the first to concern itself with drug monitoring, but it is the most comprehensive and the best of any published to date. It may represent a watershed. Interest in drug safety may once have been the exclusive province of a few specialists,...

The receipt of the following books is acknowledged, and this listing must be regarded as sufficient return for the courtesy of the sender. Books that appear to be of particular interest will be reviewed as space permits.

Psychiatry and Psychology

Handbook ...

ENERGY AND HEALTH

A conference on energy policy and environmental health will be held in KLresge Auditorium at the Massachusetts Institute of Technology in Cambridge, Mass., on February 4. Dr. Barry Commoner will be the main speaker.

Contact Helen Meltzer,...