CORONARY-artery spasm is established as the cause of Prinzmetal's variant angina, and it may have a role in the pathogenesis of other manifestations of ischeic heart disease, including unstable angina and myocardial infarction.^{1 2 3} The immediate ...

PITUITARY tumors commonly secrete excess amounts of prolactin, growth hormone, or corticotropin, resulting in characteristic clinical syndromes. The glycoprotein hormones, including thyroid-stimulating hormone (TSH), luteinizing hormone (LH), and follicle-...

THE collection of complete and detailed vital statistics from countries all over the world since World War II has made it readily apparent that the contemporary mass diseases — primarily cardiovascular diseases and cancer — are occurring in epidemic form. ...

MOST people would agree that the great successes of American medicine since World War II are due to the coupling of unparalleled advances in basic research with the clinical practice of medicine. This translation of research discoveries to the care of ...

Treatment

Several chemotherapeutic strategies have been developed for the treatment of chronic myelogenous leukemia (CML). The conventional approach is to give moderate doses of an alkylating agent or DNA-synthesis inhibitor to reduce the overproduction ...

PLATELETS have long been implicated as a cause of acute myocardial ischemia,^{1 2 3} but absolute proof is lacking. Attempts to quantitate in vivo platelet activation during myocardial ischemia have led to the development of a number of indexes of platelet ...

PATIENTS with X-linked agammaglobulinemia (X-LA) characteristically have recurrent bacterial infection; they generally have a normal response to viral infection, presumably because cell-mediated immunity is intact.^{1 , 2} A notable exception is the usually ...

No extract is available for articles shorter than 400 words.

WHEN the Food and Drug Administration released cimetidine for clinical use in 1977, only two indications were approved; short-term treatment of duodenal ulcer, and treatment of pathologic gastric acid hypersecretory conditions. Nevertheless, physicians ...

Presentation of Case

A 28-year-old man was admitted to the hospital because of hypercalcemia.

He was well until 13 months earlier, when fever developed, with a sore throat, cervical lymphadenopathy, nausea, and diarrhea. A throat culture yielded ...

What is the chance that a patient will have a particular disease, a particular test result if the disease is present, or a favorable response to therapy? Such questions are becoming increasingly common in clinical medicine as the development of predictive ...

A BOLD and exciting new technique to protect ischemic myocardium has recently been developed. In several pilot studies carried out in patients with acute myocardial infarction, it has been shown that acutely occluded coronary arteries can be recanalized ...

There are those among us who would like to believe that the development of health policy in the United States proceeds along a smoothly, or at least recognizably, progressive course. That, unfortunately, is not the case. Health-policy development proceeds ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

To the Editor: The claim by Meryash et al.¹ in the January 29 issue that "newborns who have PKU [phenylketonuria] can be identified by routine screening during the first 48 hours of life" is based on few observations, and it ignores published data.^{2 3 4} ...

To the Editor: We read with interest the article by Ochs et al. in the August 14 issue.¹ It prompted us to search the adverse-drug-reaction computer file maintained by the FDA's Division of Drug Experience² for cases in which lidocaine and propranolol ...

To the Editor: We found the article by Lee et al.¹ on elastolytic activity in the lavage fluid of patients with the adult respiratory-distress syndrome (ARDS) to be very interesting. However, we believe that several comments are in order. First of all, ...

No extract is available for articles shorter than 400 words.

To the Editor: Keshan disease is an endemic cardiomyopathy in China that has been linked to selenium deficiency,^{1 2 3} Between 1974 and 1977 a prevention study was undertaken. Among 36,603 children given selenium supplements, 21 cases of the disease ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

In this brief volume, a distinguished health-services researcher develops an orderly vocabulary and conceptual framework for defining and measuring the quality of health care. It is the first in a promised series of books on quality assessment by the same ...

No extract is available for articles shorter than 400 words.

Can social work survive? Only with radical surgery — and the patient may die on the operating table, not from the procedure but from loss of blood. Brewer and Lait question the effectiveness of social-work activities in the British context, suggesting ...

How hard it must be for the physician, trained only in cure, to stand aside and let nature take its course. Thus we see a house officer include corrective potassium supplements in the intravenous fluids for a dying man already in coma, or order aspirin ...

In this small work, the author traces the development of the hospital in Boston during the interval from 1870 to 1930. There are six chapters, the first of which deals with the hospital as a charitable institution, dependent for its operating funds on ...

This book is scholarly, well written, and readable. The author's intent is to develop a theoretical model for an understanding of the "anatomy, physiology, and development" of multihospital systems. By this term the author means a corporate entity, ...

On page 4 of this impressive tome (for a long time the only textbook in the field), its copyright history, beginning with Dr. Milton J. Rosenau's original work in 1913, covers a full page. This 11th edition opens a new era. A professional society, the ...

Physicians will enjoy this life of the brilliant younger sister of William and Henry James, because Alice James' career as an invalid illuminates an aspect of medical history rarely seen clearly. The fortunate reader will find a history of personal ...

ECHOCARDIOGRAPHY

The "Eighth Annual Seminar on Clinical Echocardiography: New Developments in Cardiac Ultrasound" will be held at the Snowbird Conference Center in Snowbird, Utah, June 30-July 3.

Contact Mary Anne Mclnerny, Extramural Programs Dept., ...