THERE has been recent speculation about the role of prostaglandins and thromboxanes in ischemic heart disease.^{1 , 2} These naturally occurring compounds are potent modulators of vascular smooth-muscle tone and platelet aggregability.³ Prostaglandin I₂ (PGI_...

IN addition to its use in the treatment of peptic ulcer, the histamine H₂-receptor antagonist cimetidine is commonly given to prevent gastrointestinal hemorrhage and aspiration pneumonitis in acutely ill patients.^{1 2 3} Recent evidence from animal ...

SPONTANEOUS rupture of an intracranial saccular aneurysm results in a death rate exceeding 50 per cent in the first month.¹ These aneurysms usually go undetected until rupture results in a clinical picture of subarachnoid hemorrhage, intracerebral ...

WHEN I first realized that I might have cancer, I felt immediately that I had entered a special place, a place I came to call "The Land of the Sick People." The most disconcerting thing, however, was not that I found that place terrifying and unfamiliar, ...

THE recent implementation of screening programs for the detection of congenital hypothyroidism has focused attention on the unique thyroid physiology and pathophysiology of the newborn. A high prevalence of both permanent and transient disorders of ...

ABLATIVE chemotherapy with allogeneic bone-marrow transplantation has become an accepted means of therapy for acute leukemia.¹ It is the only treatment capable of producing long-term unmaintained remissions in patients with acute lymphoblastic leukemia ...

Presentation of Case

A seven-year-old girl was admitted to the hospital because of bloody diarrhea and oliguria.

She was well until one week earlier, when vomiting and diarrhea developed, with a low-grade fever. Several days before admission the fever ...

IN this issue of the Journal, Feely and his co-workers convincingly demonstrate an interaction between cimetidine and propranolol that results clinically in a decrease in resting sinus rates beyond what would be expected if either propranolol or ...

Controversy continues in the neurosurgical literature concerning the treatment of patients with intracranial aneurysms. To some extent this is due to the paucity of data on the natural history of these lesions. Most patients who are found to have an ...

The possibility that nuclear weapons may cause an unprecedented catastrophe for humanity has not halted the nuclear-arms race. On the contrary, the insecurity resulting from these weapons is a factor in their multiplication. Nuclear devices of varying ...

Brown — Stephen Brown, M.D., of Amherst, died on November 24. He was in his 74th year.

Dr. Brown received his degree from Yale University School of Medicine in 1932. He served for many years as the physician in residence at Amherst College. He was a ...

To the Editor: The FDA's critique¹ of the Anturane (sulfinpyrazone) reinfarction trial^{2 , 3} and the accompanying editorial⁴ contain important lessons for the conduct and reporting of clinical trials.

In the first place, it is clear that after a finding ...

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No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

To the Editor: In Reye's syndrome, elevations of intracranial pressure (ICP) are often accompanied by acute neurologic deterioration, and many current treatment protocols use continuous ICP monitoring to determine the need for osmotic diuresis, ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

My reaction to this book was utter astonishment followed by disapproval, gradually superseded by appreciation.

The book is astonishing in several respects. Although called a "review," it has more the style of an outline, being neither interpretative, ...

The simultaneous appearance of these two books relating to neurosurgical anesthesia is timely and welcome. This discipline has been regarded more as an art than a science. Only a few practitioners have been devoted to its service. Verbal communication has ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

An anatomist and a clinician, with the support of 10 contributors from the disciplines of pathology, physiology, pediatrics, radiology, medicine, and rehabilitation medicine, have produced a new and different version of an old textbook. Previous editions, ...

Junqueira and Carneiro have produced a work on histology that lies midway between a review and a textbook; it is more than a compendium of structures, but is not encyclopedic. The authors consider histology from the standpoint of cell biology and make ...

Medicine

Physical and Rehabilitative

Behavioral Problems and the Disabled: Assessment and management. (Rehabilitation Medicine Library.) Edited by Duane S. Bishop. 473 pp. Baltimore, Williams and Wilkins, 1980. $39.

Manipulation, Traction and Massage. ...

NEUROLOGY

The 50th Anniversary Meeting of the American Association of Neurological Surgeons will be held in the Hynes Auditorium in Boston, April 5–9. Contact Dr. Stephen R. Freidberg, Lahey Clinic Medical Ctr., 41 Mall Rd., Burlington, MA 01803; or call (...