VITAMIN D must undergo successive hydroxylations, first by the liver and then by the kidney, before it can exert its influence on calcium, phosphorus, and bone metabolism.^{1 2 3 4} The detection of specific hereditary or acquired defects in vitamin-D ...

WITH current modes of therapy, acute lymphocytic leukemia in childhood is curable in approximately one third of newly diagnosed patients.¹ Such progress in treatment of neoplastic disease has now made it even more critical to anticipate the infectious ...

THE high success rate observed with antibiotic therapy in most bacterial diseases contrasts with the substantial failure rate in the treatment of bone infections. This discrepancy can be partly accounted for by a variety of specific problems pertaining to ...

HUMAN T lymphocytes are endowed with the capacity to recognize specific antigens, execute effector functions, and regulate the type and intensity of virtually all cellular and humoral immune responses.¹ Two major functionally distinct subsets of T cells ...

LIDOCAINE is commonly administered parenterally for the treatment of cardiac arrhythmias. The use of this drug is complicated by its narrow therapeutic index.¹ Any reduction in its metabolic clearance will lead to increased accumulation during long-term ...

INHERITED deficiency of the purine salvage enzyme adenosine deaminase (ADA) results in the fatal infantile syndrome of severe combined immunodeficiency.^{1 2 3 4} The accumulation of the purine substrates of ADA, adenosine and deoxyadenosine and their ...

FEW studies have been undertaken to determine how far the proctosigmoidoscope can be inserted.^{1 2 3} Many practitioners erroneously believe that proctosigmoidoscopy is successful only if the proctosigmoidoscope is inserted to its maximum, standard length ...

Presentation of Case

A three-year-old boy was admitted to the hospital because of the nephrotic syndrome.

The child's health was excellent until six weeks before admission, when he was observed to have puffy eyes. Several days later the abdomen became ...

The ability of a low-molecular-weight material from sensitized lymphocytes to transfer cell-mediated immune responses to previously unreactive recipients was reported many years ago.¹ During the past decade, there have been several investigations into the ...

To the Editor: We report here the first therapeutic use of an experimental, oxygen-transporting blood substitute, Fluosol-DA 20%. It is made and supplied by the Green Cross Corporation (1–47, Chuoh 1–chome, Joto-ku, Osaka, Japan), whose records confirm ...

To the Editor: White and Froeb state in the March 27 issue that they found differences in mid-expiratory and end-expiratory flow (FEF 25–75% and FEF 75–85%) in their comparison of nonsmokers with passive smokers and smokers. This statement is remarkable ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

To the Editor: Captopril^{1 , 2} causes long-term inhibition of angiotensin II formation, and studies have shown that it is effective in lowering blood pressure.^{3 4 5} At present there is no direct method to measure plasma levels of captopril, but it is ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

Peter Breggin's latest book, in the genre of Friedberg 's Shock Therapy Is Not Good for Your Brain, is another attempt to discredit contemporary psychiatric somatic treatments, including drugs and electroconvulsive therapy (ECT). The author first ...

No extract is available for articles shorter than 400 words.

A new series of annual reviews is introduced, written by invited experts, half of whom are faculty members of the University of California at Los Angeles. Unlike other yearbooks and annuals, the format suggests a textbook devoted to 14 major areas of ...

It would be difficult to find a better book on the topic of regulating hospital costs than the one by Abernethy and Pearson. Unlike so many works in this field, the book is eminently readable. It provides an excellent summary of the seven major theories ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

THE AMERICAN ASSOCIATION FOR HAND SURGERY

The annual meeting of The American Association for Hand Surgery will be held at the Marriott Hotel in New Orleans, September 25–28.

Contact Jean Rickli, 2704 Marshall Court, Madison, WI 53705; or call (608) 238–...

Military medicine has traditionally been somewhat remote from the civilian professional community. One of my resolves in accepting the position of Assistant Secretary of Defense for Health Affairs was to involve more civilians in military medicine. My ...