INBORN errors in adrenal steroidogenic enzymes may produce life-threatening impairment of salt and water homeostasis.^{1 , 2} Cortisol deficiency and variable genital ambiguity ensue unless the enzymatic lesion impinges selectively on the distal ...

THE nature and pathogenesis of gastrointestinal symptoms associated with drinking coffee are poorly defined. A recent study in normal subjects showed that the effects of coffee on gastric acid secretion and lower-esophageal-sphincter (LES) pressure were ...

MULTIPLE sclerosis (MS) is a chronic, relapsing and remitting disease characterized by demyelination in the central nervous system. Its cause is unknown. A large body of evidence, however, has suggested that MS is autoimmune in nature and initiated by a ...

THIS article discusses a set of predictions that contradict the conventional anticipation of an ever older, ever more feeble, and ever more expensive-to-care-for populace. These predictions suggest that the number of very old persons will not increase, ...

THE damaging effect of aspirin on the gastric mucosa has been well documented by endoscopy^{1 2 3 4 5 6} and by studies of fecal blood loss.^{7 , 8} Because of the unquestioned value of aspirin in the therapy of rheumatoid diseases and other painful ...

BECAUSE susceptibility is usually acquired by autosomal-dominant inheritance, ¹ many relatives of patients who have had attacks of malignant hyperthermia are at risk. Elevated serum creatine kinase² or increased sensitivity of isolated muscle to drugs, ...

NON-A, non-B hepatitis is a major health problem, present in up to 89 per cent of patients with post-transfusion hepatitis¹ and 25 per cent of hospitalized patients with sporadic hepatitis.² Experimental transmission to chimpanzees of human non-A, non-B ...

NEW ENGLAND has not been an area where very large verdicts have been common in medical malpractice cases. Widespread publicity was therefore to be expected when the Supreme Court of Connecticut recently upheld as proper and justified a jury verdict of $...

Presentation of Case

A 62-year-old man was admitted to the hospital because of fever.

He was well until six years previously, when he noticed enlarged lymph nodes but did not seek medical treatment. Seven months before entry he came to the medical clinic, ...

OF all the ways proposed to control the runaway costs of health care in this country, "technology assessment" is probably the least controversial. (It isn't exactly noncontroversial, but nothing is these days.) The idea that we could save money through ...

The medical profession, apparently obsessed with the need to prove itself, has come up with no less than three approaches to assessing, and assuring the public about, physician competence. Two of these approaches — awarding credit for evidence of ...

No extract is available for articles shorter than 400 words.

To the Editor: In a recent paper Koplan et al.¹ concluded that in spite of a slight element of risk, the use of pertussis-containing vaccines should continue. United States vaccines, however, contain more bacteria per dose than vaccines made according to ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

To the Editor: Physicians universally recognize unilateral pupillary dilatation to be the earliest clinical sign of uncal herniation of the brain with lateral brain-stem compression due to an ipsilateral expanding mass lesion. Although third-nerve palsy ...

To the Editor: A rapid and sustained lowering of urinary calcium excretion was the most striking change that Siris et al.¹ observed in seven of eight patients with multiple myeloma who were treated with dichloromethylene diphosphonate. This effect was ...

To the Editor: Present procedures generally require that bone-marrow aspirates be processed immediately after collection to allow a satisfactory harvest of the chromosomes for study. To avoid the necessity of immediate processing, we asked clinicians to ...

To the Editor: The article by Tilelli at al. on the sexual abuse of children (February 7 issue) is a welcome addition to the scarce literature on this topic. I am concerned, however, that the suggestions for treatment, which they draw from their data, ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

Most of the time when I have been ill, I have stayed at home in my bed to be cared for by my family. Sometimes I was fairly seriously ill. As a child I had poliomyelitis, which fortunately turned out not to be paralytic. I was frightened when I heard my ...

The first (1972) edition of this book by two highly experienced British pathologists filled a long-standing need, for no other comprehensive discussion of the morphologic aspects of diseases of the alimentary tract was available. The text offered clear ...

Reflecting the maturation of clinical genetics into a medical specialty, the wave of picture books on syndromes is now being followed by textbooks. This source book for nongeneticist physicians includes six chapters on multisystem disorders (chromosome ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

STRATEGIC FAMILY THERAPY

A conference entitled "Recent Developments in Strategic Family Therapy" will be held at Skidmore College in Saratoga Springs, New York on August 21 and 22. The fee is $75. Refunds will not be made after August 15. Contact the ...

The need and the demand for assessment of health-care technologies are growing rapidly. Biomedical research and development, especially since World War II, have dramatically increased the ability to prevent, diagnose, and manage a wide variety of ...