HYPERCALCEMIA has been a recognized complication of malignant disease since the early part of this century.¹ Although the specific mechanisms responsible for cancer-associated hypercalcemia remain uncertain, two general processes appear to be involved. In ...

HEMOGLOBIN-H disease, clinically the most important form of α-thalassemia, is a chronic hemolytic anemia found commonly in the Orient and Mediterranean. It results from an inherited defect in the synthesis of the α chains of hemoglobin.¹ The genetic ...

SINCE its description by Engel and Angelini in 1973, carnitine deficiency has emerged as the leading cause of Type I lipid-storage myopathy. In some instances, the disorder appears to be largely limited to skeletal muscle and carries a favorable ...

CURRENT knowledge of variants of phenylketonuria (PKU) originated largely in programs for neonatal screening and treatment. Accordingly, the structure of such programs is relevant to our discussion of the disease.^{7,16, 69 , 70} Different processes are ...

SYSTEMIC mastocytosis is a disorder of unknown origin, characterized by abnormal proliferation of tissue mast cells involving various organs and associated with a variety of clinical symptoms and signs.¹ Episodic attacks of flushing, frequently ...

POST-MORTEM studies have demonstrated the presence of many coronary arterial collateral vessels in the normal human heart at birth and later in life. Some of these vessels are located in the epicardium, but they are much more prevalent in the ...

A THOUGHTFUL opinion has been written by the Supreme Court of Virginia on an issue of considerable importance (and latent fear) to a growing number of physicians in this country. Who is responsible for the damages in cases of malpractice involving claimed ...

Presentation of Case

A 50-year-old woman was admitted to the hospital because of fever and abdominal pain.

Diabetes mellitus was found 15 years before admission and was regulated with diet and isophane insulin. Two years before entry a diagnosis of ...

Almost 40 years have elapsed since Albright¹ first suggested that the neoplastic tissue in a patient with renal-cell carcinoma and hypercalcemia might produce parathyroid hormone or a similar substance that would raise serum calcium. During this period, ...

Carnitine was discovered in 1905, and its structure was established in 1927. It is a relatively simple molecule that is synthesized from lysine, with terminal methyl groups donated by S-adenosylmethionine. From studies in lower species it is thought that ...

The release of products from cells is commonly called secretion. Secretion implies the release of the soluble contents of secretory vesicles by a process known as exocytosis. In recent years, however, it has become clear that exported products may be cell-...

To the Editor: We have recently treated 16 patients (14 female and two male) with toxic-shock syndrome. Since there is a dearth of medical literature on this disease, we think that a brief description of the illness and its association with ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

To the Editor: Identification of the fetus at risk for antenatal distress or death remains a perplexing problem for the obstetrician. Recent reports^{1 2 3} documented the usefulness of recording fetal movement in the management of high-risk fetuses. ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

To the Editor: Every physician who has treated terminally ill patients with cancer has undoubtedly observed the frustration and depression that these patients experience when they are no longer able to engage in meaningful activities. I wish to inform ...

No extract is available for articles shorter than 400 words.

Operative Surgery: Principles and Techniques is addressed to the experienced clinical surgeon and to the surgical resident in training. In content, it lies midway between an atlas of techniques and a textbook of principles. In 55 chapters, the 89 ...

Recent years have seen a marked increase in books directed to the general practitioner or medical specialist that offer discussions of emotional aspects of illness. These two books are part of this trend. They are both directed to a similar audience: ...

The first in a prospective series of periodic reviews on epidemiologic topics, this volume deals with "infectious diseases, other conditions, and general topics related to both" (editor's introduction). Reflecting this comprehensiveness of concerns, the ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

Harold Wolff probably carried out and participated in more studies of headache than any other worker in this century. The first two editions of his book Headache and Other Head Pain have been recognized as classics by students of headache. After Wolff's ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

The Journal's reviewer of the second edition of this standard textbook stated that it was clearly written and well illustrated and that it should be on the shelves of all anesthesia and intensive-care libraries. This third edition is even better than the ...

The receipt of the following books is acknowledged, and this listing must be regarded as sufficient return for the courtesy of the sender. Books that appear to be of particular interest will be reviewed as space permits.

Education, Medical and Related

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GYNECOLOGY

The Medical College of Wisconsin–Milwaukee will hold its 14th Annual Postgraduate Course in Gynecological Pathology, Cytogenetics and Endocrinology at the Pfister Hotel and Tower in Milwaukee, January 15–21. Registration is limited to 150. The ...