CUTIS LAXA is a clinically and genetically heterogeneous group of generalized connective-tissue disorders in which lax skin is the common feature.^{2 , 3} Two forms have been described: a dominantly inherited form^{3 , 4} involving only the dermis and a ...

THE mechanisms responsible for the severe hepatic necrosis that occasionally follows halothane anesthesia are unknown. Current hypotheses suggest that a toxic reactive intermediary metabolite¹ or a cell-damaging immune response^{2 , 3} is the basis for the ...

FOR physicians, diagnosis and treatment pose both cognitive and social problems. Study of the cognitive aspects of diagnosis and treatment decisions is a specialty in the field of decision sciences, a combination of cognitive psychology and computerized ...

ALTHOUGH oxygen therapy has been of clear benefit in many clinical settings, it also carries a risk of tissue damage. All tissues of the body can be injured by sufficiently high oxygen concentrations, but the lung is exposed directly to the highest ...

METASTATIC adenocarcinoma from an unknown primary site (ACUP) is common in most general medical and oncology practices. We and others^{1 , 2} have suggested that the role of investigations intended to define the site of such primary tumors is limited. ...

THE Sézary syndrome is characterized by generalized erythroderma, lymphadenopathy, splenomegaly, and the presence of abnormal mononuclear cells in skin infiltrates and peripheral blood.^{1 , 2} The neoplastic cells in this disorder have morphologic, ...

Presentation of Case

First admission. An 11-year-old boy was admitted to the hospital because of a mediastinal mass.

He was well until six weeks earlier, when a nasal voice and cervical lymphadenopathy were observed. One week before admission the ...

THE heritable disorders of connective tissue have been defined by McKusick¹ as generalized defects that clinically involve primarily one element of connective tissues and are transmissible in mendelian patterns. Most of the disorders of collagen or ...

Despite vitriolic controversy over the existence of halothane-induced hepatitis, a consensus has been reached that it is a distinct although rare syndrome. Early evidence was circumstantial, derived from reports associating fulminant hepatitis with ...

The federal government has increased its activities directed toward health promotion and disease prevention.* We carried out a pilot survey of a random sample of Massachusetts physicians and lawyers to obtain a profile of the personal health-promoting ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

To the Editor: In the February 7 issue, Getaz et al.¹ report their findings in two patients who had positive responses to the direct antiglobulin test while receiving cisplatin. At Vanderbilt University Medical Center, we have been impressed with the ...

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To the Editor: Rodey et al.¹ reported that black patients with insulin-dependent diabetes mellitus (IDDM) had markedly increased frequencies of HLA-DRw3 and DRw4 but no increases in B8 or B15. They concluded that the increased DRw antigens were of black ...

To the Editor: We performed a "pilot" case–control study of risk factors for cancer of the testis because of our interest in whether genital-tract cancer is related to in utero exposure to diethylstilbestrol (DES) in the male as it is in the female.^{1 2 3} ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

To the Editor: In the March 13 issue, Finkel discussed the long-standing problem of drugs of limited commercial value (orphan drugs) and the attempts by various committees to find workable solutions. The members of the Interagency Task Force on ...

Almost all the authors of the 13 articles in this book are professional philosophers, and a few have had legal training. None, as far as one can tell from their brief biographies, is a physician, although James Rachels takes pains to quote extensively ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.