ELEVATED levels of plasma high-density-lipoprotein (HDL) cholesterol may be associated with a lowered risk of coronary heart disease.^{1 2 3 4} Evidence indicates that women,^{1 , 2} middle-aged male exercisers,^{5 6 7 8 9} and nonsmokers¹⁰ have higher levels of ...

CHOLESTEROL cholelithiasis has been more common among women than men in every population examined.^{1 , 2} This difference between men and women begins during puberty, is present throughout the childbearing years, and is believed to be increased by ...

SINCE the dramatic summer of 1976, when Legionnaires' disease was first recognized,^{1 , 2} investigators have attempted to discover an environmental source of the causative bacillus and to elucidate the agent's mode of transmission. During an epidemic ...

IT is now over 20 years since Salmon and Daughaday hypothesized that stimulation of growth by growth hormone (somatotropin) was mediated by a circulating "sulfation factor."¹ An understanding of this "factor" was hampered initially by technical problems ...

BUTORPHANOL tartrate (Stadol, Dorphanol) is one of a species of narcotic analgesics or opioids that combine the properties of the common opioids and the actions of an opioid antagonist such as the widely used naloxone (Narcan).¹ The introduction of this ...

RETINAL microaneurysms and thickening of the capillary basement membrane are the hallmarks of diabetic small-vessel disease.^{1 2 3 4} Microaneurysms of retinal vessels in patients with long-standing diabetes mellitus⁴ contribute to the development of ...

Presentation of Case

A 24-year-old man was admitted to the hospital because of an abdominal mass.

Eleven years previously he was seen at another hospital because of dyspnea. Physical examination revealed right supraclavicular lymphadenopathy and slight ...

Sir Hans Krebs has emphasized that whenever there is a critical interconversion of two metabolic intermediates at a rate-limiting step in a metabolic pathway or at a branching point between two pathways, nature provides opposing unidirectional enzymatic ...

In recent years, studies of gallbladder disease have focused on the lipid composition of bile.¹ The actual function of the gallbladder in terms of contractility, residual volume, and rate of emptying has been difficult to study because of the repeated x-...

The mechanisms responsible for acceleration of atherosclerosis in diabetes mellitus and the pathophysiologic meaning of different forms of diabetic microangiopathy remain enigmatic despite considerable research aimed at elucidating the role of genetic, ...

IT has been suggested that both weight and metabolism are regulated, in part, by a common mechanism: substrate or "futile" cycling. The sensitivity of many regulatory mechanisms in metabolic pathways can be improved by the existence of a substrate cycle ...

To the Editor: The results of Rodey and his colleagues¹ confirm that the HLA antigens Dw³ and Dw⁴ are increased in black juvenile diabetics² as they are in whites. Juvenile diabetes is rare in blacks in western Africa, where 99 per cent of American black ...

To the Editor: I would like to comment on the article in the October 4 issue, in which Dr. Bergsagel and his co-workers discussed the lack of benefit of multiple alkylating-agent combination therapy over melphalan and prednisone in myeloma; I am ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

Fifty-four years intact, then flung in a blink into a hospital, lying there answering questions like a student with superior grades. Even when they began to poke and prod I knew they wouldn't find anything beyond the little lump.

Day after day they did ...

Since this book first appeared in 1961, it has been the bible of diagnostic cytology. Its success was due to the careful correlations of cytologic morphology with histopathology that provided a firm foundation for the rapidly growing field of cytology. A ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

This brief monograph identifies the sex-determining genes and explains why they must exist. Although the fact-hypothesis ratio occasionally becomes low, Ohno's teleologic approach is as refreshing here as in his previous works. Moreover, because of the ...

When Lawrence J. Henderson wrote his remarkable paper on the nature of medical practice,* he showed that medicine was process more than content — the process being the interaction between one doctor and one patient. The individuality of patients is ...

This book is one of a series of reviews designed as a reference for clinicians and biologists interested in atherosclerosis. The book contains seven chapters and over 700 references, and each chapter is written by one or more well-known specialists.

The ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

During the past decade nuclear medicine has had tremendous growth, owing to many advances in radiopharmacy and instrumentation. This growth has been accompanied by a shift of emphasis from static imaging of anatomy to analysis of organ physiology, a shift ...

No extract is available for articles shorter than 400 words.

The Collaborative Perinatal Project, as it is now known, covered 1959 to 1966 and involved 12 collaborating American institutions who registered 58,000 women in the project. Later follow-up of their offspring shows the vastness of the multidisciplinary ...

The receipt of the following books is acknowledged, and this listing must be regarded as sufficient return for the courtesy of the sender. Books that appear to be of particular interest will be reviewed as space permits.

Legal and Forensic

The Doctor's ...

FELLOWSHIPS IN INTERNAL MEDICINE

The Henry J. Kaiser Family Foundation is supporting fellowship programs in general internal medicine. Applicants should contact the appropriate program directors at the following institutions conducting the fellowship ...