Genetic variations in human beings have classically been detected by the demonstration of differences in the structures or properties of gene products. Recently, rapid advances in techniques for nucleic acid analysis have shown that variations in nucleic ...

THERE is growing recognition that primary hyperparathyroidism is not a rare disease and that it frequently exists as a seemingly mild condition lacking the florid renal and skeletal manifestations of past cases. It seems apparent that the availability of ...

Experimental and clinical data suggest that platelets may contribute to the adverse clinical events associated with atherosclerotic coronary-artery disease.^{1 , 2} Autopsy examination of the heart after sudden death has shown platelet aggregates in the ...

The concept that endocrine disease can result from resistance to hormone action was elaborated in 1942 by Albright et al., who deduced that pseudohypoparathyroidism resulted from peripheral resistance to the action of parathyroid hormone.¹ In 1957 Wilkins ...

Hormone-secreting pituitary adenomas arise as discrete nodules in the adenohypophysis, and are called "microadenomas" when they are less than 10 mm in diameter. At autopsy routine examination of pituitary glands has shown that the prevalence of ...

Effective treatment of Hodgkin's disease renation of the extent of the disease. This usually involves staging laparotomy, which includes splenectomy and biopsies of the para-aortic lymph nodes, liver, and bone marrow. Absence of the spleen predisposes a ...

Presentation of Case

A 51-year-old woman was admitted to the hospital because of a pulmonary lesion.

She was well until two months earlier, when she had pain of questionably pleuritic nature in the right posterior portion of the thorax that gradually ...

Mild, asymptomatic primary hyperparathyroidism now poses the problem of therapy that mild hypertension once did — we do not know which is more dangerous, parathyroidectomy or the untreated disease itself, when serum calcium is less than 11 mg per ...

It is generally held that impairment of coronary-artery blood flow is a major cause of angina pectoris, myocardial infarction, ventricular arrhythmias, and sudden cardiac death. These events may be precipitated through several mechanisms that affect the ...

Four states have now passed legislation that adopts a new method of capital punishment — death by drug injection. The method entails injection of a lethal dose of a drug prepared for that purpose and administered and monitored by medically trained ...

Robertson — George Joseph Robertson, M.D., of Belgrade Lakes, Maine, died on February 22, 1979. He was in his 64th year.

Dr. Robertson received his degree from Tufts College Medical School in 1943. He served as associate dean for medical education for ...

No extract is available for articles shorter than 400 words.

To the Editor: Contrary to Hermann and Cooperman's assertions (issue of August 30), scalpel biopsy of a pancreatic mass is absolutely contraindicated in any patient with a localized, potentially curable lesion. Despite any attempt at isolation of the ...

No extract is available for articles shorter than 400 words.

To the Editor: The article by Roberts and his colleagues in the February 1 issue of the Journal described the case of a 59-year-old woman with a metastatic gastric carcinoid tumor in whom the carcinoid flush was blocked by a combination of ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

To the Editor: In the July 26 issue of the Journal, Miyagi and his colleagues reported that L-glutamine decreased the urinary excretion of cystine in a 69-year-old man with classic cystinuria. Intravenously administered glutamine decreases cystine ...

No extract is available for articles shorter than 400 words.

This vast treatise was designed to summarize every important topic in endocrinology and metabolism from the most fundamental level of cell function to the most practical level of diagnosis and care. The list of editors and the nearly 200 contributors ...

This book is part of a mini-epidemic of recent publications dealing with epidemiology and health services. It takes a social-planning approach to the role of epidemiologic intelligence in health-care planning, and the final chapter provides some ...

The appearance of a second edition of a book within five years of the first indicates that the first has been well received and that the second probably will be, too. This holds true even in fields that are cluttered and crowded with books already. ...

No extract is available for articles shorter than 400 words.

Temporal events are nowhere more important than in endocrinology. This book reviews circadian and other biologic rhythms of the endocrine system. It contains a detailed description of circadian rhythms in general and of neuroanatomy and endocrine target-...

Dentistry

Dentists' Manual of Emergency Medical Treatment. By Robert J. Braun. 71 pp., illustrated. Reston, Virginia, Reston Publishing Company, 1979. $12.95.

Essentials of Complete Denture Prosthodontics. By Sheldon Winkler. 729 pp., illustrated. ...

SEMINARS IN ONCOLOGY

Roswell Park Memorial Institute will present a series of seminars in oncology: "Nutrition and Cancer," February 28; "Seminar on Bone and Soft Tissue — Malignancy," March 7; "Cancer Prevention and Detection: Update for the Community," ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

The newest prop in the federal government's leaking levees against rising health-care costs is the National Center for Health Care Technology, voted in by Congress 14 months ago to assess what works and what doesn't in medical care.

The purpose is ...