AMONG various mechanisms implicated in the pathogenesis of aplastic and hypoplastic anemias, an abnormal bone-marrow microenvironment has long been suspected.^{1 2 3 4} Experimental evidence such as radiation-induced or chemical-induced bone-marrow stromal ...

DECLINING birth rates, together with modest increases in longevity, have ushered in an era of greater concern for the elderly. Although the term "elderly" is customarily applied to people more than 65 years old, the group over the age of 75 years is ...

Redefinition of Amyloid Fibrils and Classification of the β-Fibrilloses

The diversity of the major protein component of amyloid fibrils from classically accepted sites of amyloid deposition negates the unitary concept that all amyloid proteins are derived ...

AVAILABILITY of effective medical therapy for the Zollinger–Ellison syndrome (ZES)^{1 2 3} has removed much urgency from decisions about treatment and encouraged reevaluation of various options.^{3 4 5} A recurring question posed by clinicians is whether such ...

MULTIPLE myeloma is characterized by an increase of abnormal plasma cells in the bone marrow and monoclonal protein in the serum, often with osteolytic bone lesions. Its course is progressive: anemia, weakness, fatigue, fractures, bone pain, hypercalcemia,...

THE diagnosis of a subclavian steal is entertained on clinical grounds. Classic signs are an absent radial pulse, a difference in brachial-artery pressures greater than 20 mm Hg, and sometimes a supraclavicular bruit on the involved side. These signs may ...

THE function of many endocrine glands is influenced by age and sex.¹ Only recently have these two factors been shown to influence the secretion of the calcemic peptide hormones parathyroid hormone and calcitonin.^{2 3 4} To evaluate the effects of age and ...

Presentation of Case

A 34-year-old nulliparous woman was admitted to the hospital because of right-sided pelvic pain.

Twelve years before admission the patient experienced right-sided pelvic pain during ovulation and menstruation; a physician palpated a ...

IN this issue of the Journal, Ershler et al. present the most compelling evidence to date for the existence of a naturally occurring human disease of the hematopoietic microenvironment. Their patient had long-standing and probably congenital anemia due to ...

Pseudomonas aeruginosa is an opportunistic pathogen that causes more than 100,000 infections in the United States each year. Pseudomonas infections are associated with considerable morbidity and mortality despite the use of modern antibiotics.¹ ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

To the Editor: Having been a chiropractor for 30 years, and as the father of a son about to graduate with a medical degree (University of Cincinnati Medical School), I found your discussions of chiropractic in the February 7 issue exceptionally ...

No extract is available for articles shorter than 400 words.

To the Editor: For years I have wondered why physicians-in-training are required to work for up to 48 hours without sleep, without a break. Now, I know. It's due to magic, of a sort.

In some psychiatric circles these days, people are discussing something ...

Adolescent medicine is a relatively new area of special interest for physicians. In 1951, Dr. Charles Janeway invited Dr. J. Roswell Gallagher to direct an ambulatory service for adolescents at Children's Hospital in Boston. Now there are adolescent ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

Anatomy, Histology, and Histochemistry

Biomembranes: Fundamentals in relation to human biology. By James S. Beck. 172 pp., illustrated. New York, Hemisphere Publishing Corporation, 1980. $19.95.

The Mast Cell: Its role in health and disease. Edited by J. ...

MATERNAL SERUM ALPHA-FETOPROTEIN

A national conference entitled "Maternal Serum Alpha-Fetoprotein: Issues in the prenatal screening and diagnosis of neural tube defects" will be held at the Shoreham Hotel, Washington, D.C., July 28–30.

Contact Ms. Hope ...