PRIMARY pulmonary hypertension is a progressive and fatal illness, and attempts at therapy have been discouraging. The decrease in pulmonary resistance in some patients given oxygen therapy¹ or drugs such as isoproterenol^{2 3 4 5} or tolazoline^{5 6 7 8} is at ...

A NEW rodenticide, N-3-pyridylmethyl-N′-p-nitrophenyl urea (PNU, Fig. 1), has been implicated in several hundred human poisonings during the past five years after accidental or intentional ingestion. This substance, which is unrelated to warfarin, has ...

Newer Forms of Hormone Therapy: Antiestrogens

Antiestrogens were developed as antifertility drugs. Instead, they induce ovulation in infertile women, and they may also cause regression of breast-cancer lesions. One of these drugs, tamoxifen, has been ...

PRIMARY pulmonary hypertension is a disease of unknown cause, predominantly occurring in young women and resulting in right ventricular failure and death in an average of seven years.¹ Spontaneous regression has been reported but is rare.² As yet, no ...

PRENATAL diagnostic studies are performed to determine whether a fetus believed to be at risk for a genetic disease is actually affected. For the most part, prenatal diagnosis relies on the cytogenetic or biochemical analysis of cultured amniotic-fluid ...

IN patients with hypertrophic cardiomyopathy the electrocardiogram often displays deep Q waves that may suggest myocardial infarction.^{1 2 3} Some investigators have ascribed these Q waves to the activation of the hypertrophied interventricular septum,^{4 , 5} ...

ESCHERICHIA COLI infection of the gastrointestinal tract may cause diarrhea by two pathogenic mechanisms that have been well described in laboratory animals and man: direct invasion of the intestinal mucosa and production of either heat-labile or heat-...

AS we enter a new decade the medical scene in Britain is confused, and the outlook remains uncertain. The years of expansion of the National Health Service (NHS) seem to be past, and the chill reality of Mr. Enoch Powell's claim¹ that the demands upon the ...

Presentation of Case

A newborn boy was admitted to the hospital because of respiratory distress.

The child was born after an estimated 38-week pregnancy of a mother 20 years of age who had had two previous successful pregnancies and one abortion. Birth ...

Since Dresdale et al.¹ described the clinical syndrome of pulmonary hypertension of unknown cause, i.e., primary pulmonary hypertension, in 1951, the disease has been considered uniformly fatal. Its occurrence is dramatic because young people are affected,...

Was it not enough to understand three ways that Escherichia coli could cause diarrhea? Esch. coli can acquire the ability to produce enterotoxins that are heat labile or heat stable. Inflammatory colitis is produced by other, invasive Esch. coli. Several ...

One can do something wrong to a tree, but it makes no sense to speak of wronging it. Can one wrong an animal? Many philosophers think not, and many research scientists adopt the attitude that the use of laboratory animals raises no serious moral ...

No extract is available for articles shorter than 400 words.

To the Editor: We have recently investigated possible transmission of hepatitis non-A, non-B (NANB) by a manikin used to demonstrate cardiopulmonary resuscitation (CPR) at our institution. As in hepatitis B, the role of saliva in the transmission of NANB ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

To the Editor: The article by Harmon et al.* and the letter by Baker et al. in the September 20 issue of the Journal were especially interesting with regard to the complications of long-term nitrosourea chemotherapy. I would like to add a case to the ...

To the Editor: The mechanism of myelin breakdown in multiple sclerosis (MS) is still unknown. Recently, active demyelination has been observed in fibers in contact with microglial cells containing ultrastructurally normal myelin. This finding suggests ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

To the Editor: The letter from Dr. Bitran¹ has raised an important but as yet unsettled question about prognostic factors in acute lymphoblastic leukemia in adults. On the basis of experience with 13 patients, Dr. Bitran suggested that adults with T-cell ...

To the Editor: In 1970 Engel reported in the Journal a disorder of the skeletal muscle without fasting hyperketonemia and with a normal increase in ketone bodies after oral medium-chain triglycerides.¹ He suggested a possible defect in the use of long-...

No extract is available for articles shorter than 400 words.

To the Editor: In 1974, the Joint Commission on Accreditation of Hospitals began requiring hospital medical staffs to evaluate the performance of physicians by means of medical audit — review of patient records according to clinical criteria. Soon after, ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

More and more patients with congenital heart disease are surviving into adulthood. Now that these patients are ready to leave the sheltered environment of the pediatric clinic, it is fair to ask ourselves: How ready are we to take care of them? This book, ...

No extract is available for articles shorter than 400 words.

This book tells the remarkable story of the revolution in biology termed "molecular biology." This field emerged in part from the synthesis of five distinct disciplines: microbiology, Mendelian genetics, physical chemistry, crystallography, and ...

PSRO AND REHABILITATION

The Massachusetts Rehabilitation Hospital will present a program cosponsored by the Bay State PSRO, entitled "PSRO and Rehabilitation at the Hospital and Lesser Levels of Care," on February 7 at the MIT Faculty Club.

For more ...