HIGH-DOSE chemotherapy and total body irradiation followed by bone-marrow transplantation is a relatively new treatment for patients with acute leukemia. During the early 1970's, bone-marrow transplantation was employed almost exclusively in patients ...

IN the congenital bleeding disorder known as von Willebrand's disease, quantitative and qualitative abnormalities of Factor VIII/von Willebrand factor (FVIII/vWF) (Table 1) prolong bleeding time and impair hemostasis.¹ The most severe cases of this ...

SOON after the discovery of the decapeptide structure of the gonadotropin-releasing factor luteinizing hormone-releasing hormone (LHRH), numerous analogues, both agonistic and antagonistic, were synthesized. Testing in dispersed pituitary cells of the rat ...

AS new and expensive health-care technology is developed, there is an increasing need to select the procedures that should be purchased and the patients to whom they should be applied. Analysis of cost effectiveness attempts to solve such problems by ...

Role of Genital Mycoplasmas in Disorders of the Urinary Tract

Urinary Calculi

Friedlander and Braude⁷² produced magnesium ammonium phosphate calculi in the bladders of male rats by inoculating ureaplasmas directly into the bladder or renal pelvis. Female ...

Surgical Management of Crohn's Colitis

CROHN'S disease is not necessarily limited to the small bowel, as previously believed, but may also involve the colon.¹ Colonic lesions may be present with ileal involvement, or the colon may be the only site. ...

HIGH-ALTITUDE pulmonary edema is an unusual and puzzling illness.¹,² We have seen four patients without a right pulmonary artery, all of whom had high-altitude pulmonary edema at moderate altitudes (2000 to 3000 m) in Colorado. Both of these conditions ...

DESPITE increasing interest, the modes of transmission of cytomegalovirus (CMV) infection, particularly in the first year of life, remain ill-defined. During the first year the rate of acquisition of CMV infection throughout the world is variable but high,...

Presentation of Case

A 35-year-old woman was admitted to the hospital because of chest pain.

She was well until 14 years previously, when she began to experience wheezing on exertion. Aminophylline was prescribed, with improvement. Four years before ...

Since Farber described the first complete remissions of acute leukemia in children in the Journal 32 years ago,¹ knowledge of strategies to improve survival and the quality of life in patients with this disease has increased rapidly. In this issue, Blume ...

The report in this issue describing four subjects who had acute pulmonary edema after exertion at high altitude and who had congenital absence of the right pulmonary artery is intriguing, not just because it describes a medical curiosity but because of ...

On February 1 of this year the trusters of the Massachusetts General Hospital, after months of deliberation, announced that they had decided against allowing the hospital's cardiac surgical service to begin a limited program of heart transplantation. ...

No extract is available for articles shorter than 400 words.

To the Editor: A 65-year-old man reported that he had had intermittent claudication for two weeks. Two months earlier, because of classic angina pectoris, he had begun taking propranolol, 20 mg four times a day. After one month, the dosage had been ...

To the Editor: A previously healthy 70-year-old man reported that his left breast had been enlarging and sensitive for two months. History and physical examination provided no explanation for the 3-cm tender and mobile subareolar mass. The breast tissue ...

No extract is available for articles shorter than 400 words.

To the Editor: We have successfully treated a patient with the severe form of epidermodysplasia verruciformis (EV)¹ with the oral aromatic retinoid RO-10-9359 (Roche). This form of EV is familial and characterized by widespread human papillomavirus Type ...

No extract is available for articles shorter than 400 words.

To the Editor: The report by Maeda et al.¹ of an increased prolactin response to thyrotropin-releasing hormone (TRH) during mania in four manic-depressive female patients is consistent with our own observation of a reduced prolactin secretion after TRH ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

Spurred on by aggressive carrier-state screening for Tay-Sachs disease and hemoglobinopathies, by the growing use of prenatal genetic diagnosis, by federal and state legislative activities, and by publication of several self-help books on genetics, public ...

The eighth edition of this book continues in the time-tested mode of the previous editions, as originally set in 1940 by the late Dr. Emil Novak. Written by the late Dr. Edmund R. Novak and by Dr. J. Donald Woodruff, the current edition reflects a ...

No extract is available for articles shorter than 400 words.

Groth's book provides a comprehensive clinical picture of men who commit crimes involving sexual assault, and it is a truly superb work. The style is crisp and well focused, with a clarity that is rare in clinical treatises on psychiatry and psychology. ...

No extract is available for articles shorter than 400 words.

Anyone interested in the effects of nutrients on brain function knows the work of the group at the Massachusetts Institute of Technology under Dr. Richard Wurtman's leadership. They have developed imaginative concepts and hypotheses, which have led to ...

Excessive alcohol consumption by many Americans is well known, but until now it has been difficult to find a description of the benefits and risks of alcohol in our population.

Here is a book containing much useful information that physicians and other ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

The receipt of the following books is acknowledged, and this listing must be regarded as sufficient return for the courtesy of the sender. Books that appear to be of particular interest will be reviewed as space permits.

PATHOLOGY

Color Atlas and ...

COMPUTERS

The Second International Symposium on Computers in Critical Care and Pulmonary Medicine will be held in Lund, June 3-6.

Contact Bodil Richardsson, Symposium Secretary, Kliniskt Fysiologiska Avdelningen, Lasarettet, S-221 85 Lund, Sweden.

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