MOLSIDOMINE (N-ethoxycarbonyl-3-morpholinosydnonimine) belongs to a newly discovered class of sydnonimines and has been recently introduced for the treatment of angina pectoris. Studies in animals have shown that the hemodynamic effects of the drug are ...

EXCEPT for age and sex, the strongest and most consistent risk factor for atherosclerosis and related occlusive vascular disorders is serum cholesterol concentration.^{1 2 3 4} In spite of the mass of evidence implicating cholesterol, the mechanism of its ...

PATIENTS encounter ambulatory-care services with greater frequency than any other component of the health-care delivery system. The average patient visits a physician as an outpatient three to five times yearly.^{1 , 2} Yet, in spite of the magnitude of this ...

TWELVE years ago in the Journal, Dr. F. D. Moore and his colleagues evaluated the various forms of therapy then current for the treatment of both primary and metastatic breast carcinoma.¹ In 1967 most patients with breast cancer were treated initially ...

THE polybrominated biphenyls (PBB's) and polybrominated biphenyl oxides (FBBO's) are brominated hydrocarbons that have been used commercially as fire retardants. PBB's in particular are highly lipotropic and are not readily metabolized. As a result, they ...

IN a previous study of the interaction between racemic warfarin (a mixture of the levorotatory and dextrorotatory enantiomorphs) and trimethoprim–sulfamethoxazole (TMP-SMZ) in man, marked augmentation of hypoprothrombinemia with little change in the ...

CENTRIPETAL fat deposition is a well known clinical feature of excessive endogenous or exogenous adrenal glucocorticoids. We describe an unusual case of central spinal stenosis caused by excessive epidural fat in a patient with Cushing's syndrome ...

No extract is available for articles shorter than 400 words.

Cholesterol is one of the most enigmatic molecules in human biology. On the one hand, it is an essential structural component of membranes and lipoproteins. On the other, it contributes to the pathogenesis of diseases as diverse as gallstones, ...

The association of hypertension, cigarette smoking, and elevated serum cholesterol with coronary-artery disease was demonstrated in the prospectively designed Framingham study and reported by Dawber et al. 22 years ago.¹ Numerous studies have confirmed ...

The term hospice originally designated the way stations or refuges where medieval pilgrims were sheltered, fed, and protected during their arduous journey to the Holy Lands. Today, the hospice is a resource for the patient with terminal cancer.

The ...

No extract is available for articles shorter than 400 words.

To the Editor: Siegel et al.¹ suggest that their findings are consistent with either a genetic hypothesis or the view that exercise itself explains the lower rate of coronary-heart disease among fathers of runners. The study was criticized properly in an ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

To the Editor: The article by Mahoney and his colleagues in the issue of August 9 makes the sweeping generalization that physical examination is more accurate than mammography for detecting breast cancer in a screening situation. Their conclusions are ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

The prime importance of abdominal pain as a symptom of the So-Called acute abdomen has been thoroughly imprinted on the minds of virtually every medical student since 1921, when Sir Zachary Cope's classic, The Early Diagnosis of the Acute Abdomen, was ...

No extract is available for articles shorter than 400 words.

Dr. Samuel Sanes, a pathologist who excelled as a teacher, learned in 1973 that he had a disseminated form of cancer — a reticulum-cell sarcoma of the lymph nodes. Five years later he was dead, but in the meantime he wrote a series of articles for his ...

This is a further entry in the continuing debate between those who see the mind and brain as inseparable and those who claim for the mind a separate controlling existence. Sir Karl Popper, a philosopher versed in the current conclusions of science, and ...

No extract is available for articles shorter than 400 words.

MEETING OF THE AMERICAN MEDICAL WRITERS ASSOCIATION

The New England Chapter of the American Medical Writers Association will meet at Dunfey's Restaurant in Lexington, Massachusetts, on January 16 at 6:00 p.m.

For more information write to Judith Linn, New ...

Manuscripts

Manuscripts containing original material (Original Articles, Special Articles and brief reports in Medical Intelligence) are accepted for consideration with the understanding that neither the article, nor any part of its essential substance, ...