IN 1977, two cases of pancreatic somatostatinoma were reported by Larsson¹ and Ganda² and their colleagues. On the basis of these reports and the known pharmacologic effects of somatostatin, a tentative description of the somatostatinoma syndrome was ...

TICRYNAFEN, or tienilic acid (2,3-dichloro-4[2 thienylcarbonyl]phenoxy) acetic acid, is a new nonsulfonamide diuretic with antihypertensive effects in patients¹ similar to those of the thiazides. The diuresis results from interference with the ...

HUMAN chorionic gonadotropin is secreted by the placenta and is detected early in the blood of pregnant women,¹ ultimately rising to levels of about 1 to 10 μg per milliliter. Because it is a placental protein, its presence in the blood of nonpregnant ...

ROTAVIRUS was recognized as a cause of gastroenteritis in 1974.¹ It is the major cause of "winter" gastroenteritis in infants and children^{2 3 4} and is capable of producing infections in adults after oral challenge.⁵ Rotavirus infection is also known to ...

(Second of Two Parts)

Circulating Thyroglobulin

For several decades, thyroglobulin was thought to be confined to the thyroid gland. This view can no longer be defended since thyroglobulin has unquestionably been demonstrated in the peripheral circulation ...

MAMMOGRAPHY is a rewarding method of screening for breast cancer.¹ However, surgeons have been disturbed by the fact that many clinically detected small solid breast lumps not demonstrated by mammography are found to be malignant on biopsy. We therefore ...

THERE has been a great deal of legislative activity in the 50 states of the United States in recent years in the field of commitment for mental illness. Civil-rights organizations have been largely responsible for the changes in the law. Psychiatrists and ...

Presentation of Case

A 24-year-old woman was admitted to the hospital because of virilization.

At the age of nine years she had an illness characterized by anorexia, hepatic enlargement, jaundice and hypergammaglobulinemia. The administration of cortisone ...

Human chorionic gonadotropin, a glycoprotein hormone secreted in large quantities by the placenta, normally circulates at readily detectable levels only during gestation. It shares a common quaternary structure of two dissimilar subunits (designated alpha ...

When our name was changed from the Boston Medical and Surgical Journal to the New England Journal of Medicine in 1928, it was in recognition of the fact that our orbit had by then extended well beyond the city of our birth. Although the Journal had become ...

The conclusions of the NIH consensus meeting on "The Treatment of Primary Breast Cancer" published in this issue of the Journal, deserve more consideration than mere acceptance or rejection depending on whether they support one's personal point of view. ...

No extract is available for articles shorter than 400 words.

To the Editor: Myotonic dystrophy (Steinert's disease) is an uncommon disorder of unknown cause, with involvement of smooth and striated muscle.¹ We have observed an unusual manifestation, anicteric cholestasis, in two patients with this disease.

A 49-...

To the Editor: We were interested to read the letter in which Dr. Hanin¹ questioned the use of choline and lecithin in the treatment of a number of psychiatric and neurologic diseases and concluded that the mechanisms by which these substances affect ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

To the Editor: We wish to report a favorable response to metoprolol in a patient who had essential tremor and was intolerant of propranolol.

A 65-year-old man with chronic obstructive lung disease had had the onset of tremor 15 years earlier. The tremor ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

To the Editor: Diazepam has become one of the mainstays of therapy for convulsions, anxiety and preoperative and postoperative anesthesia.¹ We have recently observed extensive adsorption of diazepam to plastic tubing during continuous infusion. Plasma ...

To the Editor: I report here a definite association between alcohol intake and bruxism, observed in four patients followed for several months.

Bruxism (nocturnal grinding or gnashing of teeth) is a common condition. It is estimated to occur in at least ...

No extract is available for articles shorter than 400 words.

To the Editor: The recent flood of articles and letters in the Journal on the relation between endometrial carcinoma and the use of estrogens serves to emphasize a serious ethical problem in medicine today. Two recent articles on this subject reached ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

This book is excellent for several reasons. Although there are nearly 50 chapters and over 75 contributors, the style is remarkably consistent. Each chapter is concise, clearly written and well documented with references. The format is exceptionally good. ...

No extract is available for articles shorter than 400 words.

These two volumes represent an enlarged and expanded version of a textbook in widespread use since 1973 by those interested in gastroenterology. The past five years have witnessed rapid advances in the pathophysiology of gastrointestinal diseases and a ...

This is a reasonably comprehensive book on coronary-artery disease by numerous contributors connected with the University of Alabama Medical Center. It summarizes 10 years of clinical research at that institution and incorporates information from basic ...

No extract is available for articles shorter than 400 words.

The receipt of the following books is acknowledged, and this listing must be regarded as sufficient return for the courtesy of the sender. Books that appear to be of particular interest will be reviewed as space permits.

Laboratory Methods and Diagnosis

...

ECONOMICS IN HEALTH POLICY

The Law and Economics Center of the University of Miami will sponsor a course in economics for those involved with health-policy issues. The course will be conducted in two phases, one in Washington, DC, on six consecutive ...

A consensus-development conference on "The Treatment of Primary Breast Cancer: Management of local disease" was held at the National Institutes of Health on June 5, 1979. The purpose of the conference was to address the question of whether there are ...