HUMAN leukocyte interferon, a protein produced by stimulated leukocytes, induces an antiviral state in other cells. It is relatively nontoxic and nonantigenic in homologous hosts. The antiviral state produced by interferon is active against most ...

THE exercise test has been used to help detect ischemic heart disease. Correlations between results on the exercise test and coronary arteriography have demonstrated that, in symptomatic men, the presence of an abnormal ST-segment response to stress ...

THE term vasculitis denotes inflammation and necrosis of blood vessels. The process may be the primary manifestation of several clinical syndromes or it may be a relatively minor feature of other primary diseases. The heterogeneous group of disorders ...

(First of Two Parts)

THE thyroid has two main endocrine functions: secretion of the thyroid hormones thyroxine (T₄) and triiodothyronine (T₃) by the follicular cells and secretion of calcitonin by the C cells. Thyroid hormones are first synthesized as a ...

WE have recently studied a patient who had short-bowel syndrome that presented with peculiar neurologic manifestations and severe metabolic acidosis. The anion gap was increased, but the identity of the abnormal anion was not readily apparent. By several ...

ESCHERICHIA COLI L-asparaginase, an antileukemic agent, acts by hydrolyzing plasma L-asparagine to L-aspartic acid and ammonia, resulting in depletion of plasma L-asparagine levels.^{1 , 2} Cells susceptible to the cytotoxic effects lack asparagine ...

MEDULLARY thyroid carcinomas always secrete calcitonin, leading to an increased plasma hormone concentration.¹ The plasma calcitonin concentration usually correlates with the clinical extent of disease.²

This article describes a patient with medullary ...

Presentation of Case

A 24-year-old man was examined in the clinic because of swelling of the hands and feet.

He was well until two months previously, when he noticed swelling of the dorsum of the hands and was unable to make a tight fist. Subsequently, ...

The Coronary Artery Surgery Study on exercise stress testing, discussed this week in the Journal,¹ is an important addition to a recent series of articles exploring the reliability and limitations of exercise testing in the detection of underlying ...

The spectrum of systemic vasculitis has long fascinated clinicians and investigators alike. Important steps toward understanding the pathogenesis of this group of disorders have been made with the finding of presumptive circulating immune complexes and ...

To the Editor: The report by Dr. Tamborlane and his colleagues¹ confirmed our preliminary results^{2 3 4} on short-term, continuous, subcutaneous insulin infusion (CSII) in insulin-dependent diabetics. The portable Auto Syringe that they used clearly has a ...

To the Editor: The importance of hepatitis B e antigen (HBeAg) and antibodies in acute and chronic hepatitis B virus infection is still not understood, but the availability of sensitive methods for detection has shed more light on the occurrence of this ...

To the Editor: Despite the generally good sensitivity and the consequent widespread use of the creatine phosphokinase MB band in the diagnosis of myocardial infarctions, this isoenzyme has been reported in a variety of disorders.¹ Widespread destruction ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

To the Editor: In the last two years, we have seen several families with Marfan's syndrome. These families showed two clinical pictures not described by Pyeritz and McKusick¹ in the April 5 issue of the Journal. These families required treatment by ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

To the Editor: In the April 26 issue of the Journal, Dr. Ericson and his colleagues reported that lead levels in man have increased about 100-fold from ancient times to the present.¹ The discovery of lead dates back to at least 3500 B.C. Excavations at ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

To the Editor: In the past few decades, increasing numbers of women have decided to pursue academic and research careers. The percentage of doctoral degrees earned by women has more than doubled in the past 12 years, increasing from 10.8 per cent in 1965 ...

One of the most important problems in human biology resides in the mechanism underlying the switch from fetal to adult hemoglobin. An understanding of this problem has both theoretic and practical implications, for its solution would provide insights into ...

This book provides a comprehensive review and analysis of the diverse international literature on the epidemiology of diabetes mellitus and its vascular complications. The author has done a remarkable job in synthesizing the vast amount of information ...

The central propositions in Samuel Epstein's book are that exposure to chemical and physical agents in the environment is the primary cause of human cancer, that cancer should be regarded as preventable and that prevention depends primarily on political ...

The watchword in cancer management today is "multidisciplinary," and this volume is true to the belief that only through the interaction of various disciplines can patients with cancer get the best treatment. This book is directed to students and ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

This book is refreshingly frank. It is written by a British general practitioner with a clearly stated point of view: "No health service functions efficiently or serves the needs of people effectively unless it has a well-organized system of primary care."...

PROGRAMS FROM BOSTON UNIVERSITY

Boston University Medical Center will present the following programs in the coming months: "Issues and Advances in Human and Clinical Nutrition," August 13–17; "Cast Bracing and Functional Bracing," September 14 and 15; "...

The costs of medical care continue to escalate and are a matter of grave national concern. Inflation, recent adjustments in salaries for workers who previously were underpaid and the great surge in public demands for increased services are important ...