IDIOPATHIC hemochromatosis is determined by a locus closely linked to the A locus of the HLA complex on chromosome 6.^{1 , 2} The disease becomes clinically manifest in patients homozygous for the predisposing allele^{3 , 4} indicating a recessive mode of ...

EXISTING evidence indicates that hemochromatosis is an autosomal-recessive disorder and that the locus for hemochromatosis is closely linked to the HLA region on chromosome 6.^{1 , 2} Simon et al.¹ obtained a lod score of +2.2 for linkage to the HLA region. ...

CLINICAL research must provide sound data that clinicians can rely on in making decisions about patients. This kind of research should help to establish a body of knowledge that is useful in answering the following clinical questions: What medical ...

ESOPHAGEAL motor disorders are clinical abnormalities in esophageal motility that are caused by a disruption in the neurohumoral or muscular control of peristalsis or lower-esophagealsphincter (LES) function. Recent progress in the classification, ...

STANDARD treatment for myeloma has involved use of the oral alkylating agent melphalan, given either continuously or intermittently with prednisone.¹ These regimens produce objective responses in 40 to 50 per cent of patients, as measured by a decline in ...

SINCE Crawhall et al. reported on the use of D-penicillamine in cystinuria,¹ this drug has been thought to provide the best treatment for the disease. The drug converts cystine into more soluble disulfide compounds, thus preventing the formation of ...

AS anticipated, when Mrs. Margaret Thatcher-formed her new government, she appointed Mr. Patrick Jenkin to be Secretary of State in the Department of Health and Social Security (DHSS), with Dr. Gerard Vaughan as Minister of Health. During the last few ...

Presentation of Case

A 20-year-old man was admitted to the hospital because of hemoptysis and anemia.

He was well until 18 months earlier, when he began to have recurrent hemoptysis at intervals of several months. The episodes were characterized by ...

The two articles on hemochromatosis in this issue, by Beaumont and her colleagues from Rennes, France, and by Cartwright and his associates from Salt Lake City, Utah, show how genetic-linkage studies can be used to clarify the mode of inheritance and to ...

Humanism and holism have hit the medical profession with the searing force of righteous anger, and the health-care system will never be the same. As a powerful counterforce to the increasing technology and dehumanization of post-Flexnerian medicine,^{1 , 2} ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

To the Editor: We read with interest the article by Farber and Finkelstein¹ describing the costs as compared with the benefits of premarital screening for immunity to rubella. Their conclusion that the effort would not be justifiable depended largely on ...

To the Editor: I regret that the space limitations imposed by the Journal prevent a detailed response to the lengthy attack on the Massachusetts Determination of Need Program published in the April 5 issue.

A few observations will serve to indicate why ...

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The publication of a new textbook of medicine merits comment if only because of the magnitude of such an undertaking, but a book that attempts to accomplish two other unusual goals as well — to remain up to date each month and to provide a mechanism to ...

Basch undertook a task no one else had the courage to try. Whereas previous books have concentrated on specific areas of the field, such as the books by Bryant and King on the health problems of developing countries, Basch has produced an introductory ...

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This book, a highly scientific account of what happened through the ages to the tubercle bacillus and to persons who tried to tame it, reads like a historical novel, full of suspense, irony and even romance. The book traces the devastating effect of ...

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SYMPOSIUM ON HAIR TRANSPLANTATION

The American Society for Dermatologic Surgery will present their 1979 Hair Transplant Symposium, September 14–16 in New York City.

For more information write to Dr. George L. Popkin, 4277 Hempstead Tpke., Bethpage, NY ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.