THE treatment of choice for combined immunodeficiency disease is an HLA-matched bone-marrow transplant, preferably from a sibling or relative, but, unfortunately, appropriate donors cannot often be found. Attempts at reconstitution with transplantation of ...

A decrease in global ejection fraction, an increase in end-diastolic volume or a decrease in regional wall motion shown by means of resting gated blood-pool imaging indicates heart disease.^{1 , 2} Borer et al. have demonstrated the feasibility of obtaining ...

RECENT clinical trials of aspirin and sulfinpyrazone have suggested that drugs that inhibit prostaglandin and thromboxane synthesis in platelets decrease the death rate in men who have had a myocardial infarction.^{1 2 3} These studies have not been ...

(First of Two Parts)

THE pulmonary-alveolar macrophage (PAM) is the resident mononuclear phagocyte of the lung and functions as the primary defense against inhaled particulate matter.^{1 , 2} The study of these cells in animals became practical in 1961 when ...

ADRENOLEUKODYSTROPHY is a sex-linked recessive disease of childhood characterized by diffuse abnormality of cerebral white matter and adrenal atrophy.¹ A syndrome of spastic paraparesis and hypoadrenalism has been recently described as ...

SEVERE bradycardia has been reported with the use of cimetidine.^{1 2 3} Bradycardia could have been spurious, but it recurred on rechallenge.^{1 , 2} Data from animal studies^{4 , 5} and human right-atrial fibers⁶ indicate that histamine-enhanced automaticity is ...

MANY forms of human cancer tend to occur in families.¹ Environmental causes of familial cancer often cannot be identified, and, by exclusion, a hereditary mechanism is postulated on the basis of pedigree analysis. However, published chromosomal studies of ...

IN 1958 a serendipitous observation led to the discovery that oral administration of small doses of neomycin reduced the concentration of plasma cholesterol in man.¹ Neomycin is a nonabsorbable aminoglycoside antibiotic with a broad spectrum of activity. ...

MARROW transplantation provides the opportunity for aggressive antileukemic therapy without regard to marrow toxicity.¹ We have reported the application of this approach combined with intensive chemoradiotherapy in patients with several classes of ...

Presentation of Case

A 77-year-old woman was admitted to the hospital because of a goiter.

There was a history of multinodular goiter that dated back to her youth. Three years before admission a right mastectomy was performed because of carcinoma. Six ...

The remarkable family study of renal carcinoma reported in this issue of the Journal provides us with the first example of a dominantly inherited chromosomal aberration that imposes a high risk of a specific cancer. In this pedigree a translocation ...

Grades are symbols intended to summarize estimates of students' abilities and accomplishments. Assigning grades, like prescribing drugs, can be helpful or harmful and can have direct effects and side effects. Most grading practices evolved to serve ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

To the Editor: In the January 18 issue of the Journal, Dr. Shelley and her colleagues¹ and Dr. Smith,² in a companion editorial, present information about the composition of pulmonary surfactant in tracheal and pharyngeal aspirates from infants with ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

To the Editor: Three infants, five to six months of age, had been given Neo-Mull-Soy formula (Syntex Laboratories, Palo Alto, California) for three to six months before hospitalization in June, 1979, for evaluation of failure to thrive. The heights of ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

Would anyone have guessed that the two issues in portal hypertension most hotly debated during the last quarter century would have been settled without argument among the 60 surgeons and internists at a recent international meeting in Rome? Pending ...

The receipt of the following books is acknowledged, and this listing must be regarded as sufficient return for the courtesy of the sender. Books that appear to be of particular interest will be reviewed as space permits.

Public Health & Geographic ...

"INTELLIGENT" MACHINES IN PATIENT CARE

A consensus-development conference sponsored by the National Institutes of Health and entitled "The Use of Microprocessor-Based, 'Intelligent' Machines in Patient Care" will be held in Silver Spring, Maryland, ...