IN 1976 the Center for Disease Control identified the first penicillinase-producing Neisseria gonorrhoeae.¹ These strains contain the plasmid that codes for an enzyme that inactivates penicillin by opening the beta-lactam ring.² Such strains have ...

CLASSIFICATION of the non-Hodgkin's malignant lymphomas continues to generate much controversy.^{1 2 3} The Rappaport histologic classification⁴ is currently most widely used. Although its clinical usefulness, reproducibility and feasibility have been ...

EXPERIMENTAL studies have shown that metronidazole (Flagyl) is both carcinogenic and mutagenic.^{1 2 3 4} Nevertheless, there have been no long-term studies of human beings exposed to the drug. Metronidazole was introduced into the United States in 1960 for ...

GLUCOSE-6-phosphate dehydrogenase deficiency, an inherited lack of the red-cell enzyme, results from any of a large number of structural-gene mutations.¹ The common glucose-6-phosphate dehydrogenase mutants, A- and Mediterranean, are characterized ...

WHILE evaluating patients with the syndrome of inappropriate secretion of antidiuretic hormone, it became apparent to me that hypouricemia was common during the period of hyponatremia. Review of the literature showed only one report of hypouricemia ...

ENDOSCOPIC retrograde cholangiopancreatography as a diagnostic procedure in patients with persistent, unexplained upper abdominal pain has disclosed numerous cases of pancreatic ducts with areas of constriction and distal dilatation. These changes are ...

ON theoretic grounds, B-mode ultrasonography is an ideal tool for studying the parathyroids. It is a safe, noninvasive method, and operation of the equipment requires no special skills. To date, however, conventional diagnostic ultrasound instruments have ...

CALCIUM is the most abundant cation in human beings. The total body content averages about 25,000 mmol, or 1 kg, in a 70-kg man — virtually all of it occurring in bone.¹ Perhaps the most important biochemical property of calcium is that it forms salts ...

Presentation of Case

A 69-year-old man was admitted to the hospital because of hepatic enlargement.

He was well until five months earlier, when he became anorectic and lost 11 kg in weight. Peripheral edema was found, and a diuretic was administered. Four ...

Edis and Evans describe in this week's issue the use of high-resolution ultrasonography to localize parathyroid tumors before operation. From the standpoint of the parathyroid surgeon, a procedure that could identify the parathyroids preoperatively and ...

Hypouricemia^{1 2 3} may occur as a consequence of decreased formation of urate or increased renal clearance of urate. It can also result when the activity of xanthine oxidase is reduced, either because of deficiency of the enzyme, as in xanthinuria, or when ...

Two types of parents request fetal sex identification by amniocentesis: the first group risk transmitting a sex-linked hereditary disorder and the second want to select the gender of their next child. Physicians generally encourage the first type of ...

To the Editor: In the March 15 issue, Sepe et al.¹ questioned the use of follow-up tests to detect cases of phenylketonuria (PKU) missed on initial screening. Their questioning should not go unchallenged since they have neglected relevant and broader ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

To the Editor: We would like to add a note of caution about platelet transfusions and alloimmunization to Dr. Gale's otherwise excellent review of acute myelogenous leukemia.¹ His statement that "Most investigators believe that the frequency of ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

The recent rapid growth of imaging technology-nuclear medicine, diagnostic ultrasound and computerized axial tomography and the sudden availability of a plethora of "scans and grams" have bewildered house officers and seasoned practitioners alike. The ...

No extract is available for articles shorter than 400 words.

Textbooks on clinical parasitology, tropical medicine or general pathology rarely describe the pathologic processes in tropical diseases in any depth. We have long needed comprehensive coverage of tropical pathology, and the two volumes under review ...

This book deals with an enormously important problem. Evidence from many countries suggests that malnutrition is the single most important contributor to mortality of children. In much of Asia, Africa and Latin America, the problem appears to be getting ...

The education of health and medical-care administrators has been studied by formal commissions on three separate occasions over the last 30 years. The most recent effort, initiated in 1972 under the sponsorship of the W. K. Kellogg Foundation, was a ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

For persons who write about our country's past, and try to understand the ideas and social institutions generated by its growth, few subjects are more difficult to grapple with than slavery. Our preoccupation with slavery involves more than a basic desire ...

PROGRAMS FROM TUFTS UNIVERSITY

Tufts University School of Medicine will present the following programs: "Clinical Conferences at the New England Medical Center Hospital" on 13 consecutive Wednesdays beginning September 19; "Advances in Hypertension and ...