THE glucose-6-phosphate dehydrogenase locus can be used to study the origin of neoplasms because it is on the X chromosome and undergoes inactivation. Thus, in females, only one of the two genes regulating glucose-6-phosphate dehydrogenase is active in ...

INTERFERON was first recognized as a soluble antiviral glycoprotein induced by viruses.¹ Recently, it was shown that there are at least two types of interferon. Type I, or standard, interferon is produced by both nonlymphoid and lymphoid cells in response ...

REDUCED renal blood flow and glomerular filtration are common in essential hypertension,¹ but the causes for the reduced filtration rate are unknown; candidates include fixed changes in the afferent arterioles or glomeruli,² a functional change in the ...

(First of Two Parts)

COLLAGEN is the major macromolecule of most connective tissues, and it is widely believed that many human diseases, particularly chronic diseases, will be found to involve this protein either directly or indirectly. Since collagen ...

SYSTEMIC amyloidosis frequently involves the gastrointestinal tract and may result in obstruction, malabsorption, ulceration, hemorrhage or perforation as well as impaired motility.^{1 2 3} It is unclear whether the impaired gastrointestinal motility is ...

POLYVALENT pneumococcal vaccines have recently been used in infants,¹ children² and adults.³ They are safe, immunogenic and protective against pneumococcal disease in normal adults.³ However, all pneumococcal serotypes are not represented in the vaccines, ...

EXCESSIVE consumption of alcohol was known to be related to liver disease before the time of Hippocrates, but the recognition of alcohol-related diseases that affect cardiac and skeletal muscle is only about a century old. Alcohol use was suggested as a ...

Presentation of Case

A 66-year-old man was admitted to the hospital because of right hemiplegia and aphasia.

There was a long history of abdominal discomfort, and in recent years the patient had experienced chest pain on exertion. Fifteen months before ...

The Office of Education of the Department of Health, Education, and Welfare is proposing new regulations for determining whether medical schools located outside the United States and Canada are eligible to participate in the Guaranteed Student Loan ...

A single operation, coronary-artery bypass, has gained unprecedented popularity despite lack of unequivocal evidence that it prolongs the life of most patients. This situation has evoked editorial pleas for prospective, randomized studies of the procedure,...

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No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

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To the Editor: The treatment of Cushing's disease by use of o,p′-dichlorodiphenyldichloroethane (o,p′-DDD), as described by Luton et al.¹ in the March 1 issue of the Journal, ignores the advance provided by the introduction of the trans-sphenoidal ...

To the Editor: I read with interest the article in which Shelley and her colleagues¹ nicely demonstrated that surfactant from premature infants with hyaline-membrane disease has a different phosphatidylcholine fatty acid composition from that in a ...

To the Editor: We were recently consulted about a patient in a hospital in a semirural area who had received a 1-g bolus of lidocaine. The patient was a 54-year-old woman smoker who had gone to a local emergency room complaining of one week of ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

To the Editor: Take Care of Yourself ¹ attempts to improve patient decisions by providing direct advice, specific information and the incentive to assume greater personal responsibility. Direct advice is presented as algorithms; the relevant information ...

No extract is available for articles shorter than 400 words.

Once upon a time, there was a hospital accountant in Philadelphia named Stephen Girard O'Toole. His father had been one of the poor white orphan boys educated at Girard College — hence the son's name. As is so commonly the case with such young men, ...

The receipt of the following books is acknowledged, and this listing must be regarded as sufficient return for the courtesy of the sender. Books that appear to be of particular interest will be reviewed as space permits.

Anatomy, Histology and ...

PROBLEM SOLVING IN MEDICINE

A conference on the role of problem solving in medicine, sponsored by the University of Vermont, will be held October 19–21 at Smuggler's Notch, Vermont. Abstracts are invited; the deadline for submission is August 15.

For more ...

Manuscripts

Manuscripts containing original material (Original Articles, Special Articles and brief reports in Medical Intelligence) are accepted for consideration with the understanding that neither the article, nor any part of its essential substance, ...