ARE strokes on the decline? Analysis of mortality statistics undertaken in several countries during the past two decades suggests that they are.^{1 2 3 4 5 6} However, limitations imposed by changes in diagnostic fashion,⁷ coding practice,⁸ coverage in death ...

THE occurrence of second cancers in patients previously treated for Hodgkin's disease has been attracting attention.^{1 2 3 4 5 6 7} The development of acute myelocytic leukemia has been of special interest because of the suggestion that it may be related to ...

CUSHING'S disease is the result of excessive pituitary ACTH secretion, leading to bilateral adrenal hyperplasia and excessive cortisol secretion. No treatment of this disease has been fully satisfactory, since bilateral total adrenalectomy can result in ...

ABNORMALITIES in sensitivity to endogenous hormones and neurotransmitters as well as to exogenous drugs pervade clinical medicine. Idiosyncratic responses to medication are well known, but their causes are rarely ascertained. Although chronic decreases in ...

BRETYLIUM tosylate (Bretylol) is a bromobenzyl quaternary ammonium compound (Fig. 1). In the fifties bretylium was shown to inhibit release of norepinephrine from adrenergic nerve endings¹ and found its first clinical use in the treatment of hypertension.^...

WE recently described two groups of patients with severe insulin-resistant diabetes and acanthosis nigricans.¹ In these patients the defect of insulin action could be correlated with markedly abnormal binding of insulin to the insulin receptor, and in one ...

HIPPOCRATES observed that epileptic patients had fewer seizures during febrile illnesses, and data gathered during epidemics of measles and typhoid in patients institutionalized at Bicêtre and Salpêtrière supported his conclusion.¹ Since the development ...

THE medical-malpractice-insurance crisis of the mid-1970's produced some effective reforms in the litigation of claims as well as in the availability of adequate insurance coverage for beleaguered physicians and hospitals.¹ It also resulted in some ...

Presentation of Case

First admission. An 84-year-old woman was admitted to the hospital because of jaundice.

She was well until three years previously, when a Billroth II operation was performed because of a duodenal ulcer with obstruction of the gastric ...

Good news is worth telling and retelling. Age-adjusted cardiovascular mortality rates have declined almost 32 per cent over the last 30 years. In the last 10 years, however, the decrease has accelerated precipitously, accounting for over two thirds of the ...

Despite a variety of efforts aimed at altering its course, atherosclerosis and its sequelae are still major causes of death in the United States and other industrialized nations. In the absence of a single, clearcut etiologic agent, therapeutic ...

The subject of the specialty and geographic distribution of physicians has become a common topic for discourse within the executive and legislative branches of the government, many professional organizations and foundations, and among individual ...

To the Editor: In their editorial¹ criticizing the Horwitz and Feinstein paper on endometrial cancer,² Hutchison and Rothman claim that a sample of patients with endometrial cancer selected from a gynecologic-cancer treatment center will be unbiased for ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

To the Editor: Chlorpheniramine maleate is a widely used antihistamine. The commonly recommended oral dosage for adults is 4 mg every four hours, or three to four times a day. It has been stated that its therapeutic effects start within 15 to 30 minutes, ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

To the Editor: The implications of the report by Strohl et al. and the editorial by Turino and Goldring in the November 2, 1978, issue of the Journal deserve further comment.

Using polysomnography, workers in all major sleep-disorders centers in this ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

The author states that this book is "primarily intended as a reference work and the numerous illustrations have been selected to show the characteristic details of as many syndromes as possible." Overall, this objective has been achieved.

The study of ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

Agree or disagree? "Most current problems in U.S. medical care are attributable to interferences with competition, and the primary goal of public policy in health should be to reintroduce marketplace incentives, specifically price competition." If you ...

The receipt of the following books is acknowledged, and this listing must be regarded as sufficient return for the courtesy of the sender. Books that appear to be of particular interest will be reviewed as space permits.

History and Biography

Class ...

LECTURES ON PERINATAL RESPIRATORY DISEASES

The Massachusetts Thoracic Society and the Lung Associations throughout Massachusetts announce the availability of a traveling lecture series on the prevention and early diagnosis and treatment of perinatal ...

No extract is available for articles shorter than 400 words.