IN a set of studies published some years ago,^{1 2 3} we found that several types of histologic changes in bronchial epithelium occurred far more frequently in cigarette smokers than in nonsmokers, increased with amount of cigarette smoking and, among ...

IN most children with adenosine deaminase deficiency a severe, fatal immunodeficiency develops.^{1 2 3 4 5} Although they may have some residual immunocompetence at birth,³ it rapidly diminishes. The processes by which progressive immunologic attrition ...

RESPIRATORY syncytial virus, the most important viral respiratory pathogen of infants and young children,^{1 2 3} produces its most severe disease in the first six months of life, when specific maternal antibody is uniformly present. Indeed, an immune ...

THE carcinogenic effects of ionizing radiation are well established,¹ but the invention of the atomic bomb produced a new source of exposure to ionizing radiation by the creation of long-lived radioactive isotopes. Although survivors of the Hiroshima and ...

(Second of Two Parts)

Failure of Separation of Parts

Webbing

Webbing of the fingers is among the more common congenital anomalies of the hand.⁹⁵ Webbing between fingers of disparate length causes rotation and angulation that may worsen unless the fingers ...

THE purpose of this report is to describe a patient with Waldenström's macroglobulinemia and a hemorrhagic disorder secondary to immunoadsorption of factor VIII by peripheral blood lymphocytes and by lymphocytes in a markedly enlarged spleen. Factor VIII ...

IN 1970¹ the government decided that the medical-school intake in Britain should be increased so that about 4000 doctors would graduate annually from 1980 onward. Delays in the expansion of medical-school building have made it impossible to reach this ...

THE first step in the action of insulin, as in the actions of all polypeptide hormones, is binding to receptor molecules on the plasma membrane of the cell.¹ The receptor serves to recognize the specific hormone in the plasma, to bind it and then, as a ...

Presentation of Case

A nine-year-old girl was admitted to the hospital because of coma.

She was born of a full-term, uneventful second pregnancy in a mother 21 years of age. On the second day of life abdominal distention was observed, and she was ...

Everyone knows that cigarette smoking is bad for health, and most people are tired of being reminded about it. Nonetheless, the topic keeps on recurring because no one seems to know exactly what to do about it.

The latest reminder of the evils of smoking ...

The widely held belief that the respiratory syncytial virus is the single most important respiratory-tract pathogen in infants and young children was initially based on cross-sectional studies of infants and children coming to hospital settings. The virus ...

A paradox that is likely to remain with us for some time is that although we probably know more about the carcinogenic effects of ionizing radiation than about those of any other environmental agent, our knowledge about radiation effects at low-dose ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

To the Editor: We^{1 , 2} and others were initially very enthused about the use of computerized tomographic scanning in dementia. Besides the obvious benefit of identifying unsuspected brain tumors, abscesses and subdural hematomas, it was believed that the ...

No extract is available for articles shorter than 400 words.

To the Editor: There is no doubt that the number of patients suffering from ototoxic effects is on the increase owing to a large and increasing number of drugs now known to be ototoxic. It is not yet practical to abolish the use of all known ototoxic ...

No extract is available for articles shorter than 400 words.

To the Editor: Dr. Ingelfinger will be delighted to learn that the "Graying of Grand Rounds" (his Sounding Board in the October 5, 1978, issue of the Journal) has not yet occurred at Johns Hopkins. Grand Rounds are attended each Saturday by 300 to 400 ...

No extract is available for articles shorter than 400 words.

To the Editor: My role in the United Kingdom is in the field of community medicine, with particular involvement in health policy and the planning of health services. During four visits to the United States during the last eight years I have made a point ...

To the Editor: The article by Weinberg and Bell in the October 19, 1978, issue of the Journal touches on many interesting issues, but the analysis of data that they present in certain areas may not be as valid as it appears. It is my concern that the ...

No extract is available for articles shorter than 400 words.

The receipt of the following books is acknowledged, and this listing must be regarded as sufficient return for the courtesy of the sender. Books that appear to be of particular interest will be reviewed as space permits.

Social Topics

Access: The guide ...

PROGRAMS FROM THE UNIVERSITY OF MINNESOTA

The University of Minnesota will present the following programs: "Allergy and Clinical Immunology," March 1–3; "Invitational Conference on Psychiatric Factors of Drug Abuse," March 4–6; "Psychiatry for the Primary ...

No extract is available for articles shorter than 400 words.

Secretary Califano says that the health-related spending that the Administration has proposed for the fiscal year that begins next October 1 is aimed at "disciplining the inefficient and eliminating the wasteful," and that it reflects "prudence as well as ...