IN an attempt to find an agent with a greater therapeutic index than vitamin A or its naturally occurring derivative, all-trans-retinoic acid, new analogues (synthetic retinoids) have been developed for the primary purpose of chemoprophylaxis of cancer.¹ ...

CHRONIC granulocytic leukemia is a fatal disease with a consistent chromosomal abnormality. The death rate after the first year is a constant 20 to 30 per cent per year, with a median survival time of two to four years in reported series and with few long-...

IDIOPATHIC hypercalciuria occurs in about 40 per cent of patients who form calcium renal stones, and is an important, remediable cause of stone disease.^{1 2 3} It is not so much a demarcated illness as a quantitative departure from the normal range, defined ...

TREATMENT of renal calyceal and pelvic calculi by dissolution has been attempted for decades.^{1 2 3 4 5 6 7} A number of solutions^{8 9 10 11} and catheter arrangements^{12 , 13} have been tried, but despite sporadic reports of successfully dissolved stones, ...

(First of Two Parts)

CONGENITAL deformities of the hand and forearm affect one child out of every 626 live births.¹ Ten per cent of these infants have partial absence of the involved limb, with serious loss of function.² To the geneticist and the ...

AS Schultz¹ has noted the incidence and prevalence of human leishmaniasis is unknown. It is an endemic, sporadic infection in Central and South America, Africa, southern Europe, Asia and the Orient. It has been neglected by investigators in infectious ...

PROPRANOLOL has been widely used in the preparation of thyrotoxic patients for operation,^{1 2 3} in the treatment of thyroid storm,^{4 5} and as adjunct⁶ or sole⁷ therapy in the symptomatic management of hyperthyroid subjects. Several observers, however, have ...

Presentation of Case

An 80-year-old woman was admitted to the hospital because of intestinal obstruction.

She was well until one year previously, when she entered another hospital because of abdominal pain; gallstones were found, but she refused an ...

Acne, a common inflammatory skin disorder beginning usually in adolescence but occasionally in later years, is distressing for those whom it afflicts, principally because of its customary localization on the face. Fortunately, the disease usually ...

Chronic granulocytic leukemia is a rare disease representing approximately less than one quarter of the adult leukemias. Despite its rarity, the disease has attracted a considerable interest. The demonstration of a consistent chromosomal abnormality, the ...

Though preparations purporting to dissolve urinary stones have been advocated for several thousand years, such "litholytics" could be put on a scientific basis only when the composition of all the main forms of stone had been worked out, a task ...

An estimated five million poisonings occur in the United States each year, causing over 5000 deaths. As a cause of accidental death, poisonings are surpassed only by motor-vehicle accidents, drownings and burns.¹ This problem did not begin to attract ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

To the Editor: The report by Gartenberg et al. in the November 16, 1978, issue of the Journal emphasized the association between the use of Elastoplast and cutaneous rhizopus infections. We report here a possible association between Elastoplast use and ...

No extract is available for articles shorter than 400 words.

To the Editor: At present, infections with herpes simplex viruses Types 1 and 2 have become epidemic. Herpes progenitalis (due to Types 1 and 2) is the most common venereally transmitted disease that we see in our dermatologic practice. The oncogenic ...

No extract is available for articles shorter than 400 words.

To the Editor: Early chronic, oral-toxicity studies of the di-isopropylammonium salt of dichloroacetate in dogs revealed no noteworthy histologic or clinical evidence of drug toxicity.¹ Since publication of our initial report on the effects of sodium ...

To the Editor: It puzzles me that a major pharmaceutical firm has introduced, with a spate of glowing promotion, a combination drug called Limbitrol. It contains the tranquilizer chlordiazepoxide (Librium) and the psychostimulant amitriptyline (Elavil or ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

To the Editor: The nonmedical intranasal use of cocaine has resulted in remarkably few problems demanding clinical attention.^{1 , 2} Recently, I have detected a growing trend toward increased use of cocaine by smoking, a practice associated with ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

To the Editor: Although a number of the questions discussed in Dr. Harry Schwartz's Sounding Board article in the November 9, 1978, issue of the Journal contrasting the differences between traditional fee-for-service medical care and the medical care in ...

Drs. Yen and Jaffe have provided a comprehensive treatment of an increasingly important area of medical concern. In the past decade, the field of reproductive endocrinology, previously relatively static, has taken on new dimensions, spearheaded by a ...

No extract is available for articles shorter than 400 words.

Coming on the heels of his highly controversial Sociobiology, The New Synthesis (1975), E. O. Wilson's new book, On Human Nature, was expected to cause a stir.

At the outset he genially warns the reader that his "speculative essay...might easily be wrong —...

The familiar theme of this book, written for a general audience, is that United States medical care is in "crisis. " Despite vast resources devoted to medical care, the authors report high levels of public dissatisfaction with health services, levels of ...

The receipt of the following books is acknowledged, and this listing must be regarded as sufficient return for the courtesy of the sender. Books that appear to be of particular interest will be reviewed as space permits.

Anatomy and Histology

Abrégé d'...

LABORATORY PROCEDURES IN CLINICAL PRACTICE

Tufts University School of Medicine and the Faulkner Hospital will present a program entitled "Application of Laboratory Procedures to Clinical Practice — Part III: Electrolytes, Blood Gases, Nephrology" at the ...