WITH few exceptions, follow-up studies have demonstrated a higher mortality rate in cigarette smokers than in nonsmokers.^{1 2 3 4 5 6} Most medical scientists now agree that cigarette smoking is an important factor in causing death from lung cancer and from ...

THE first case–control studies that demonstrated a strong association between replacement estrogens and endometrial cancer were published in December, 1975.^{1 , 2} Further data supporting the association appeared in June, 1976.³ Despite these and subsequent ...

SEVERAL hereditary disorders that result in resistance to androgen action have been characterized in detail.^{1 2 3 4 5 6 7} In the syndromes of complete testicular feminization^{1 2 3} and incomplete testicular feminization⁴ and in the Reifenstein syndrome,^{5 6} ...

IMPROVEMENTS in sanitation, housing and nutrition, as well as the conquest of many infectious diseases, have resulted in striking demographic changes during this century. More than 50 per cent of those who have ever been over the age of 65 are alive ...

PRAZOSIN (l-[4-amino-6,7-dimethoxy-2-quinazoline]-4-[2-furoyl]-piperazine) (Fig. 1), the first of a new class of antihypertensive agents, was released for clinical use in the United States in 1976.¹ Although it has been used effectively as a single agent, ...

THE circulating mediator (or mediators) responsible for flushing seen in patients with carcinoid syndrome has remained unidentified. The patient described in this study, a 54-year-old woman with a metastatic gastric carcinoid tumor, has experienced ...

PROPONENTS and users of Laetrile (amygdalin) claim that the substance has no toxic side effects, even in large doses. FDA warnings that amygdalin may be toxic¹ have been overlooked² in the face of the controversy regarding the use of the drug as a ...

Total parenteral nutrition is a major advance in nutritional support, but is not without deleterious effects.¹ Several animal studies have shown reversible functional and structural gastrointestinal atrophy in response to total parenteral nutrition.^{2 3 4} ...

Presentation of Case

A 64-year-old man was admitted to the hospital because of fever.

There was a long history of excessive use of alcohol and tobacco and of chronic obstructive pulmonary disease. Five months before admission he entered another hospital ...

Approximately 15 per cent of all marriages are involuntarily childless, and another 10 per cent of couples have fewer children than they desire. In 30 per cent of these marriages, the husband can be identified as the responsible factor, and in another 20 ...

Despite a few prominent demurrers,^{1 , 2} most of the many recently published comments on controlled clinical trials^{3 , 4} have strongly supported the conviction that they are increasingly needed — one admirable worker even arguing that "no treatment regimen ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

To the Editor: In the April 6, 1978, issue of the Journal Bibbo et al. reported the cancer incidence and mortality experience of a cohort of women exposed to diethylstilbestrol in a clinical trial in 1951–52.¹ We cannot agree with the authors' ...

To the Editor: I am worried that members of the medical community are likely to misinterpret some key language in the Law-Medicine Note on the Dinnerstein decision by Schram, Kane and Roble in the October 19, 1978, issue of the Journal.

The authors argue ...

The receipt of the following books is acknowledged, and this listing must be regarded as sufficient return for the courtesy of the sender. Books that appear to be of particular interest will be reviewed as space permits.

Microbiology

Essentials of ...

EPILEPSY FOUNDATION OF AMERICA

The Training and Placement Service of the Epilepsy Foundation of America provides counseling, training and placement for persons with epilepsy.

Further information may be obtained from the Epilepsy Society of Massachusetts, ...