KALLIKREINS, or kininogenases (EC 3.4.21.8), are endopeptidases that generate vasoactive kinin polypeptides from plasma α₂-globulin substrates, or kininogens. Kallikreins have been identified in pancreas, salivary glands, sweat, urine and plasma. ...

NAUSEA and vomiting occur commonly after administration of many anticancer drugs and are sometimes so intolerable that patients abandon potentially curative chemotherapy. Unfortunately, the antiemetic drugs currently used are only minimally active when ...

WE believe that the only truly responsible position for the medical profession to take in its defense against increasing government encroachment is to support a competitive market in which total health-care spending and the level of doctors' incomes are ...

LEGISLATIVE proposals for national health insurance range from comprehensive schemes to more limited proposals that would pay for only certain categories of health expenses. It is sometimes assumed that expenditures under a categoric program would be ...

IN 1972, McCombs published an elegant review of diseases due to immunologic reactions in the lungs.¹ Since then, intense interest in pulmonary immunology has provided new insights into the role of immunologic mechanisms in many pulmonary diseases. It is ...

FOR the second time in only a few years, a huge tragedy has taken place, involving the deaths of hundreds of American citizens in a remote place outside the United States. Once again, the handling of a large-scale disaster by the United States government ...

Presentation of Case

A 6 1/2-year-old girl was admitted to the hospital because of sexual precocity.

She was born of an uncomplicated, full-term delivery of the first pregnancy in a mother aged 20 years. Her birth weight was 3.5 kg, and her length 49.5 ...

Last month two more notable awards came to Franz Ingelfinger, our Editor Emeritus. On May 6, at its annual meeting in Washington, DC, the august Association of American Physicians made him the 52d recipient of its George M. Kober medal, and a few weeks ...

The practice of medicine has two major goals: the prolongation of life and the relief of suffering. I think that few persons will deny that efforts to make life more tolerable are at least as important as those to extend it. Yet, the paradox is that the ...

In this issue of the Journal, Havighurst and Hackbarth take up the cudgels for market-oriented approaches to the problem of health-care costs. Their cause has much to commend it. They deliberately keep the discussion on an abstract plane, asserting that ...

No extract is available for articles shorter than 400 words.

To the Editor: Guanine deaminase, a catabolic enzyme, is important in purine metabolism. Guanine is a metabolic precursor of xanthine and ammonia, and the action of guanine deaminase on guanine is an indirect source of uric acid in tissues containing ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

To the Editor: Dr. Kenneth Sterling deserves to be congratulated for keeping an open mind about the mechanism of thyroxine action (January 18 and 25 issues of the Journal). He brings together information from a large and complex literature and emphasizes ...

To the Editor: We agree with Fox et al., who reported in the issue of February 22 that computerized tomography of the head (CT scan) is a test of limited value for predicting the severity or outcome of dementia in the elderly. They correctly point out ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

This compilation of papers, presented at the 1978 annual meeting of the American College of Psychiatrists, represents a balanced treatment of several important aspects of geriatrics. It is not aimed only at psychiatrists but should be helpful to all ...

No extract is available for articles shorter than 400 words.

This volume represents the publication in book form of a 16-article symposium that first appeared in Seminars in Hematology in 1978. Whether this new volume benefits anyone other than the publishers is uncertain since most libraries and indeed most ...

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The receipt of the following books is acknowledged, and this listing must be regarded as sufficient return for the courtesy of the sender. Books that appear to be of particular interest will be reviewed as space permits.

Radiology and Radiation

Atlas of ...

PROGRAMS FROM HEARING CONSERVATION NOISE CONTROL

Hearing Conservation Noise Control will present the following programs at the University of Maine in Bangor: "27th Occupational Hearing Loss Institute," July 16–20; "16th Industrial Hearing Conservation ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.