MALE pseudohermaphrodites with a deficiency of the enzyme 5α-reductase^{1 2 3} raised as girls provide a unique opportunity for evaluation of the effects of testosterone and the sex of rearing in the determination of gender identity in man. Because of a ...

DIGOXIN and quinidine are frequently used in combination for the treatment of various cardiovascular disorders. Gold et al.¹ noted potential hazards with this combination 46 years ago. Recently, several reports have shown that plasma concentrations of ...

CONTROLLED experimentation is now regarded as the principal way to collect scientific data on the value of medical treatments. The day is rapidly receding when ex-cathedra judgments dominate therapeutics. The term "clinical trial" is reserved for this ...

PHYSICIANS have been accused of prolonging life at any cost. However, surveys of health professionals have found that many (50 to 70 per cent) are disposed to withdraw or withhold life-prolonging treatment; some (30 per cent) would favor euthanasia in ...

MICROSURGERY may be broadly defined as surgery performed under the magnification provided by an operating microscope.¹ Although Nylén used a simple monocular microscope in patients in 1921, microsurgical technics have only been employed in most surgical ...

HUMAN renal allografts may be rejected within hours after transplantation. This type of rejection is usually associated with pre-existing antibodies against donor ABO-group antigens or lymphocyte antigens.^{1 , 2} The importance of pre-existing antibodies ...

AT a time when the proportion of women entering British medical schools is approaching a parity with men, it is not surprising that there should be concern to ensure that the professional expectations of women doctors will have a reasonable chance of ...

Presentation of Case

A 38-year-old man was admitted to the hospital because of fever.

The patient had a long history of chronic glomerulonephritis with renal failure. Eight years before admission he underwent bilateral nephrectomy and received a left ...

In some animal species, gonadal steroids affect the central nervous system during fetal or postnatal life (or both) in such a way that they influence sexual behavior and regulate gonadotropin secretion by the hypothalamic-pituitary system. For example, ...

AN elderly patient in a nursing home, hopelessly incapacitated by an incurable disease, has a fever that is most likely due to pneumonia or some other serious infection. Should the physician in charge respond with the usual diagnostic or therapeutic ...

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AN academic physician was once heard to remark, "If it weren't for the patients, we could get a lot of work done around here." This obviously facetious comment reflects a fundamental and profound conflict faced by those who do research on human subjects: ...

The basic law of this country, the common law, has dealt very little with the complex issues of human rights presented by randomization. The fundamental legal approach to this subject would start with an examination of the duty owed to the subjects in the ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

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To the Editor: On this golden anniversary of Wintrobe's introduction of erythrocyte indexes,¹ a reappraisal is in order. With the widespread use of the Coulter S counter, indexes are now readily available. However, it is not generally appreciated that ...

To the Editor: We should like to call attention to a viable option for the management of patients with meningococcemia, septic shock and disseminated intravascular coagulation. We recently treated a patient with extensive plasmapheresis. The patient ...

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To the Editor: A report of radiation-associated myeloma among nuclear workers at Hanford, Washington,* prompted the following unblinded study of 89 cases of myeloma in Massachusetts. We wished to determine whether radiation exposure or any other factors ...

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No extract is available for articles shorter than 400 words.

To the Editor: It has been clearly shown that the incidence of de novo malignant tumors has increased in patients treated by organ transplantation.¹ Malignant tumors have been reported only sporadically or in small series in uremic patients treated with ...

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No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

One hears a good deal about adult education these days, but this quite unusual book served as my introduction to "Courses by Newspaper," a national program originated and administered by University Extension, University of California at San Diego, and ...

This provocative and stimulating book presents the author's "thesis that the medical-education system in the country directly and indirectly creates obstacles to adequate care delivery." To remedy this situation, Dr. Jonas advocates substituting "Health ...

The receipt of the following books is acknowledged, and this listing must be regarded as sufficient return for the courtesy of the sender. Books that appear to be of particular interest will be reviewed as space permits.

Molecular Biology

Molecular ...

THE STUDY OF HEADACHE

The Annual Meeting of the American Association of the Study of Headache will be held on June 23 and 24 at the Parker House in Boston.

For more information write to Dr. Seymour Diamond, Diamond Headache Clinic, 5252 N. Western Ave., ...