GRAFT-versus-host disease (GVHD) represents a major obstacle to the success of allogeneic bone-marrow transplantation for treatment of human disease.^{1 2 3 4 5} Acute and chronic forms of GVHD have been described.⁴ The acute form usually develops several ...

ONE of the theoretical indications for attempting allogeneic bone-marrow transplantation in patients with acute leukemia is the possibility that the marrow graft will exert an antileukemic effect.^{1 , 2} Evidence of this effect in rodent tumor systems has ...

PUBLIC-HEALTH programs to control gonorrhea emphasize selective culture examination of asymptomatic women, early diagnosis of symptomatic infection, adequate treatment of established cases and identification and treatment of recently exposed sex partners. ...

(Second of Two Parts)

Sulfobromophthalein

Initial model-based studies of sulfobromophthalein (BSP) dynamics involved investigations in which the plasma disappearance curve of intravenously administered BSP was resolved into two exponential functions. Two ...

METABOLIC acidosis has been thought to elevate serum potassium concentration.^{1 , 2} However, hyperkalemia was not found in recent studies in patients with postictal lactic acidosis³ or in dogs infused with lactic acid^{4 , 5} or 3-hydroxybutyric acid5 — ...

HERPES simplex virus (HSV) is now recognized as the leading cause of severe endemic encephalitis in the United States and Europe.¹ The fatality rate in patients diagnosed by virus isolation from brain is approximately 60 to 80 per cent, and many survivors ...

TOXOPLASMIC hepatitis has been described as a clinical entity,^{1 2 3 4 5 6 7 8} usually as the primary manifestation of acute, acquired toxoplasmosis without adenopathy. Hepatitis can occur also as a late complication of the disease, when lymphadenopathy ...

Presentation of Case

A 78-year-old woman was admitted to the hospital because of weakness.

There was a long history of weakness of the ankles and difficulty with gait. Five years before entry she fractured her left hip in a fall; three years later she ...

The central feature of the immune system is that it usually manages to distinguish precisely between normal tissue of the body and foreign material. Immunologic destruction of microbial agents and the cells in which some of these agents take up residence ...

The medical community continues to witness the remarkable versatility of micro-organisms as they successfully adapt to living with antibiotics and related antimicrobial agents. The staphylococcus and gramnegative enteric organisms first demonstrated these ...

In the past 30 years there has been an explosion of knowledge about normal biologic functions and disease pathogenesis. Although methods of prevention, diagnosis and treatment have improved, the most meaningful impact of progress on clinical research has ...

Deaths

Grimes — Arthur James Grimes, Jr., M.D., of Ipswich, died on June 10. He was in his 62d year.

Dr. Grimes received his degree from Georgetown University School of Medicine in 1942. He served with the Army Medical Corps during World War II and was a ...

To the Editor: The cause of sudden-infant-death syndrome is still unexplained¹ and is probably multifactorial.^{2 , 3} We wish to report on a patient initially diagnosed as having this syndrome and who exhibited abnormal feeding and electrocardiographic ...

No extract is available for articles shorter than 400 words.

To the Editor: Recently, there has been a revival of interest in cholinergic mechanisms as they relate to psychiatric and neurologic diseases. Choline and lecithin have been given to patients with tardive dyskinesia, choreiform movement disorders, ...

To the Editor: We were not offered the opportunity to reply simultaneously to the letter of Falk et al.¹ and wish to clarify several points. Although the data of Falk et al. appear to corroborate the observation of increased peak II phosphorylation in ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

To the Editor: The editorial by Richman highlights recent progress in the development of temperature-sensitive mutants for live, attenuated influenza-virus vaccines.¹ Although one is tempted to think that intranasal immunization would be more acceptable ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

The receipt of the following books is acknowledged, and this listing must be regarded as sufficient return for the courtesy of the sender. Books that appear to be of particular interest will be reviewed as space permits.

Education

Bacteriology Virology ...